Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Nileeka Balasuriya"'
Autor:
Tarana Siddika, Nileeka Balasuriya, Mallory I. Frederick, Peter Rozik, Ilka U. Heinemann, Patrick O’Donoghue
Publikováno v:
Cells, Vol 11, Iss 23, p 3834 (2022)
Protein kinase B (AKT1) is a serine/threonine kinase and central transducer of cell survival pathways. Typical approaches to study AKT1 biology in cells rely on growth factor or insulin stimulation that activates AKT1 via phosphorylation at two key r
Externí odkaz:
https://doaj.org/article/c298f968b214421fa1429d174d9c4f93
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2021)
Protein kinase B (AKT1) is hyper-activated in diverse human tumors. AKT1 is activated by phosphorylation at two key regulatory sites, Thr308 and Ser473. Active AKT1 phosphorylates many, perhaps hundreds, of downstream cellular targets in the cytosol
Externí odkaz:
https://doaj.org/article/9591c82afa654846af8f9e5a5f0a6c9c
Autor:
Mallory I. Frederick, Tarana Siddika, Pengcheng Zhang, Nileeka Balasuriya, Matthew A. Turk, Patrick O’Donoghue, Ilka U. Heinemann
Publikováno v:
Cells, Vol 11, Iss 5, p 821 (2022)
The phosphoinositide-3-kinase (PI3K)/AKT pathway regulates cell survival and is over-activated in most human cancers, including ovarian cancer. Following growth factor stimulation, AKT1 is activated by phosphorylation at T308 and S473. Disruption of
Externí odkaz:
https://doaj.org/article/5475aaef8228444ca137ca5e6504464e
Autor:
Lewis C. Cantley, Nileeka Balasuriya, Shawn S.-C. Li, Patrick O'Donoghue, Huadong Liu, Jared L. Johnson, Kyle K. Biggar, Norman E. Davey
Publikováno v:
J Biol Chem
Paediatrics Publications
Paediatrics Publications
Protein kinase B (AKT1) is a central node in a signaling pathway that regulates cell survival. The diverse pathways regulated by AKT1 are communicated in the cell via the phosphorylation of perhaps more than 100 cellular substrates. AKT1 is itself ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87dc5ab91c6a0611841036211975a55c
https://doi.org/10.1074/jbc.ra119.012425
https://doi.org/10.1074/jbc.ra119.012425
Autor:
Ilka U. Heinemann, Mallory I. Frederick, Christina Z. Chung, Tarana Siddika, Nileeka Balasuriya
Publikováno v:
RNA Biol
In the cell, RNA abundance is dynamically controlled by transcription and decay rates. Posttranscriptional nucleotide addition at the RNA 3ʹ end is a means of regulating mRNA and RNA stability and activity, as well as marking RNAs for degradation. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6a1cb883b6b8b8dcab6deb774fd2b3
Publikováno v:
Cellular and molecular life sciences : CMLS. 78(10)
Since its discovery in 1981, the Ku complex has been extensively studied under multiple cellular contexts, with most work focusing on Ku in terms of its essential role in non-homologous end-joining (NHEJ). In this process, Ku is well-known as the DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e101cee29bc7c2f5c92c533b34cb495
https://pubmed.ncbi.nlm.nih.gov/33855626
https://pubmed.ncbi.nlm.nih.gov/33855626
Publikováno v:
Frontiers in Bioengineering and Biotechnology
Frontiers in Bioengineering and Biotechnology, Vol 8 (2021)
Frontiers in Bioengineering and Biotechnology, Vol 8 (2021)
Protein kinase B (AKT1) is hyper-activated in diverse human tumors. AKT1 is activated by phosphorylation at two key regulatory sites, Thr308 and Ser473. Active AKT1 phosphorylates many, perhaps hundreds, of downstream cellular targets in the cytosol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb641e0e04520e3551e9bcba93a3b16a
https://pubmed.ncbi.nlm.nih.gov/33614606
https://pubmed.ncbi.nlm.nih.gov/33614606
Autor:
Emad Manni, Xuguang Liu, Shawn S.-C. Li, Christina Z. Chung, Nileeka Balasuriya, Patrick O'Donoghue, Ilka U. Heinemann
Publikováno v:
Paediatrics Publications
RNA Biol
RNA Biol
The de-regulation of microRNAs (miRNAs) is associated with multiple human diseases, yet cellular mechanisms governing miRNA abundance remain largely elusive. Human miR-122 is required for Hepatitis C proliferation, and low miR-122 abundance is associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ad4348ac64adc158c241465a425e96
Autor:
Andrew K. Swanson, Chukwunonso E.C.C. Ejike, Stephanie A. Collins, Beth Mason, Nileeka Balasuriya, Chibuike C. Udenigwe
Publikováno v:
Trends in Food Science & Technology. 59:30-36
Background Bioactive peptides have strong potential for use in functional food formulation for prevention and management of health conditions, especially cardiovascular disease (CVD). Microalgae can be used as sustainable protein sources in the produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::789b837e42dfa829d83b9adb4adf8569
https://doi.org/10.1016/j.tifs.2016.10.026
https://doi.org/10.1016/j.tifs.2016.10.026
Publikováno v:
Genes, Vol 9, Iss 9, p 450 (2018)
Genes
Volume 9
Issue 9
Paediatrics Publications
Genes
Volume 9
Issue 9
Paediatrics Publications
Protein kinase B (Akt1) is a proto-oncogene that is overactive in most cancers. Akt1 activation requires phosphorylation at Thr308
phosphorylation at Ser473 further enhances catalytic activity. Akt1 activity is also regulated via interactions be
phosphorylation at Ser473 further enhances catalytic activity. Akt1 activity is also regulated via interactions be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5524fb80b740a80fab0e771a921ad488
http://www.mdpi.com/2073-4425/9/9/450
http://www.mdpi.com/2073-4425/9/9/450