Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Nilay, Sethi"'
Autor:
Aurel Prosz, Haohui Duan, Viktoria Tisza, Pranshu Sahgal, Sabine Topka, Gregory T. Klus, Judit Börcsök, Zsofia Sztupinszki, Timothy Hanlon, Miklos Diossy, Laura Vizkeleti, Dag Rune Stormoen, Istvan Csabai, Helle Pappot, Joseph Vijai, Kenneth Offit, Thomas Ried, Nilay Sethi, Kent W. Mouw, Sandor Spisak, Shailja Pathania, Zoltan Szallasi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Due to a demonstrated lack of DNA repair deficiencies, clear cell renal cell carcinoma (ccRCC) has not benefitted from targeted synthetic lethality-based therapies. We investigated whether nucleotide excision repair (NER) deficiency is prese
Externí odkaz:
https://doaj.org/article/939969bbc4324201be410156a45cd9e5
Autor:
Adam J. Bass, Haisheng Zhang, Tianshu Liu, Nilay Sethi, Yanxi Zhang, Xiaoyan Liang, Jin Zhou, Tianxia Li, Pranshu Sahgal, Yichen Wang, Feifei Zhang, Ke Peng
Z Scores from ORF screen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e5e59e37ac338408c958b781544a7f
https://doi.org/10.1158/1078-0432.22488588.v1
https://doi.org/10.1158/1078-0432.22488588.v1
Autor:
Adam J. Bass, Haisheng Zhang, Tianshu Liu, Nilay Sethi, Yanxi Zhang, Xiaoyan Liang, Jin Zhou, Tianxia Li, Pranshu Sahgal, Yichen Wang, Feifei Zhang, Ke Peng
Supplementary figure 1. CDK6 overexpression promotes FAK inhibitor resistance in SNU668. Supplementary figure 2. CDK4/6 inhibitor enhanced the efficacy of FAK inhibitors in Cdh1-/-RHOAY42C/+ organoids. Supplementary figure 3. Combination of defactini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e6604b5d0cbc2397641d7efc81eb77
https://doi.org/10.1158/1078-0432.22488597
https://doi.org/10.1158/1078-0432.22488597
Autor:
Adam J. Bass, Haisheng Zhang, Tianshu Liu, Nilay Sethi, Yanxi Zhang, Xiaoyan Liang, Jin Zhou, Tianxia Li, Pranshu Sahgal, Yichen Wang, Feifei Zhang, Ke Peng
Purpose:Diffuse gastric cancer (DGC) is an aggressive and frequently lethal subtype of gastric cancer. Because DGC often lacks genomic aberrations that indicate clear candidate therapeutic targets, it has been challenging to develop targeted therapie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59896931475d5ab934e01940b87bc391
https://doi.org/10.1158/1078-0432.c.6532767.v1
https://doi.org/10.1158/1078-0432.c.6532767.v1
Autor:
Rachel B. Keller, Tali Mazor, Lynette Sholl, Andrew J. Aguirre, Harshabad Singh, Nilay Sethi, Adam Bass, Ankur K. Nagaraja, Lauren K. Brais, Emma Hill, Connor Hennessey, Margaret Cusick, Catherine Del Vecchio Fitz, Zachary Zwiesler, Ethan Siegel, Andrea Ovalle, Pavel Trukhanov, Jason Hansel, Geoffrey I. Shapiro, Thomas A. Abrams, Leah H. Biller, Jennifer A. Chan, James M. Cleary, Steven M. Corsello, Andrea C. Enzinger, Peter C. Enzinger, Robert J. Mayer, Nadine J. McCleary, Jeffrey A. Meyerhardt, Kimmie Ng, Anuj K. Patel, Kimberley J. Perez, Osama E. Rahma, Douglas A. Rubinson, Jeffrey S. Wisch, Matthew B. Yurgelun, Michael J. Hassett, Laura MacConaill, Deborah Schrag, Ethan Cerami, Brian M. Wolpin, Jonathan A. Nowak, Marios Giannakis
Publikováno v:
JCO Precision Oncology.
PURPOSE With the growing number of available targeted therapeutics and molecular biomarkers, the optimal care of patients with cancer now depends on a comprehensive understanding of the rapidly evolving landscape of precision oncology, which can be c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25b750fdb827491918b84d39feefb934
https://doi.org/10.1200/po.22.00342
https://doi.org/10.1200/po.22.00342
Autor:
Alan D. D'Andrea, James M. Cleary, Nilay Sethi, Harshabad Singh, Brandon M. Huffman, Jonathan A. Nowak, Stephanie K. Dougan, Andrew J. Aguirre, Geoffrey I. Shapiro, Brian M. Wolpin, Srivatsan Raghavan
Publikováno v:
Clin Cancer Res
Pancreatic cancer is rapidly progressive and notoriously difficult to treat with cytotoxic chemotherapy and targeted agents. Recent demonstration of the efficacy of maintenance PARP inhibition in germline BRCA mutated pancreatic cancer has raised hop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::248d6a8e338fa601409d1ef15c837c38
https://doi.org/10.1158/1078-0432.ccr-21-1367
https://doi.org/10.1158/1078-0432.ccr-21-1367
Development of combination strategies for Focal Adhesion Kinase inhibition in Diffuse Gastric Cancer
Autor:
Ke Peng, Feifei Zhang, Yichen Wang, Pranshu Sahgal, Tianxia Li, Jin Zhou, Xiaoyan Liang, Yanxi Zhang, Nilay Sethi, Tianshu Liu, Haisheng Zhang, Adam J. Bass
Publikováno v:
Clin Cancer Res
Purpose: Diffuse gastric cancer (DGC) is an aggressive and frequently lethal subtype of gastric cancer. Because DGC often lacks genomic aberrations that indicate clear candidate therapeutic targets, it has been challenging to develop targeted therapi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0723e60c04532ed15525672b395b221
https://pubmed.ncbi.nlm.nih.gov/36278961
https://pubmed.ncbi.nlm.nih.gov/36278961
Autor:
Helen Tanton, Tomasz Sewastianik, Hyuk-Soo Seo, David Remillard, Roodolph St. Pierre, Pratyusha Bala, Daulet Aitymbayev, Peter Dennis, Keith Adler, Ezekiel Geffken, Zoe Yeoh, Nicholas Vangos, Filip Garbicz, David Scott, Nilay Sethi, James Bradner, Sirano Dhe-Paganon, Ruben D. Carrasco
Publikováno v:
Science advances. 8(17)
Dysregulated Wnt/β-catenin signaling is implicated in the pathogenesis of many human cancers, including colorectal cancer (CRC), making it an attractive clinical target. With the aim of inhibiting oncogenic Wnt activity, we developed a high-throughp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc79ffbe443556f8926e7b3f6bfdc143
https://pubmed.ncbi.nlm.nih.gov/35486727
https://pubmed.ncbi.nlm.nih.gov/35486727
Autor:
Jie Bin Liu, Ewa Sicinska, Roderick T. Bronson, Chunyang Bao, Osamu Kikuchi, James M. McFarland, Jean-Bernard Lazaro, Yanxi Zhang, Gina N. Duronio, Adam J. Bass, Francisco Sanchez-Vega, Nilay Sethi, Rameen Beroukhim, Keith L. Ligon, Matthew D. Stachler, Ruben Ferrer-Luna, Deepa T. Patil
Publikováno v:
Nature genetics
Nature genetics, vol 52, iss 2
Nature genetics, vol 52, iss 2
Somatic alterations in cancer genes are being detected in normal and premalignant tissue, placing greater emphasis on gene-environment interactions that enable disease phenotypes. By combining early genetic alterations with disease-relevant exposures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5260d2680e1d1697900bc0cb1ecb2f85
http://europepmc.org/articles/PMC7031028
http://europepmc.org/articles/PMC7031028
Autor:
Brandon M. Huffman, Haley Ellis, Alexander C. Jordan, William A. Freed-Pastor, Kimberly Perez, Douglas A. Rubinson, Nilay Sethi, Harshabad Singh, Rishi Surana, Brian M. Wolpin, Andrew J. Aguirre, James M. Cleary
Publikováno v:
Cancers. 14:6223
The aggressive biology of pancreatic ductal adenocarcinoma (PDAC), along with its limited sensitivity to many systemic therapies, presents a major challenge in the management of patients with metastatic PDAC. Over the past decade, the incorporation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd0d8d9ea0fa8d0fa03d8f74b43c8e0
https://doi.org/10.3390/cancers14246223
https://doi.org/10.3390/cancers14246223