Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Nilambari Yewalkar"'
Autor:
Veena R. Agarwal, Somesh Sharma, Avinash More, Anagha Damre, Rajiv Sharma, Sanjay Kumar, Nilambari Yewalkar, Vijaykumar Deore, Lakshmi S. Kolla, Julie Bose, Sarika Chaudhari, Nikesh Desai, Magesh Venkatraman, Asavari Joshi, Srinivas Boreddy, Dimple R. Bhatia, Archana Jalota-Badhwar
Supplementary Table S1; Supplementary Figures S1-S2. Supplementary Table 1. A) IC50 value of P7170 in pan-PI3K. B) Kinase inhibition data (ProQinase) of P7170 at 250 nM and 1. 5 μM.C) Kinase inhibition profile (KINOMEscan; 320 kinases) of P717
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25173fc0ee98eb8b60c1909b4e3f991
https://doi.org/10.1158/1535-7163.22502247.v1
https://doi.org/10.1158/1535-7163.22502247.v1
Autor:
Asavari Joshi, Anagha Damre, Veena R Agarwal, Magesh Venkatraman, Rajiv Sharma, Nikesh Desai, Julie Bose, Srinivas Reddy Boreddy, Lakshmi Sireesha Kolla, Nilambari Yewalkar, Archana Jalota-Badhwar, Sarika Chaudhari, Avinash More, Vijaykumar Deore, Somesh Sharma, Dimple Bhatia, Sanjay Kumar
Publikováno v:
Molecular Cancer Therapeutics. 14:1095-1106
The mTOR pathway is often upregulated in cancer and thus intensively pursued as a target to design novel anticancer therapies. Approved and emerging drugs targeting the mTOR pathway have positively affected the clinical landscape. Recently, activin r
Autor:
Mandar R. Bhonde, Kalpana Joshi, Vijaykumar Deore, Nikesh Desai, Amol Padgaonkar, Asavari Joshi, Anagha Damre, Pradeep Kumar, Manoj V. Lohar, Pallavi Godse, Ramswaroop Mundada, Dimple Bhatia, Rajiv Sharma, Nilambari Yewalkar, Sanjay Kumar, Sonal M Manohar
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 13:1460-1466
Hypoxia-inducible factor-1α (HIF-1α) and signal transducer and activator of transcription 3 (STAT3) are transcription factors and are activated in response to hypoxia. Both HIF-1α and STAT3 regulate various aspects of cancer biology such as cell s
Autor:
Ramswaroop Mundada, Seema Ranaware, Sanjeev Kumar, Manoj V. Lohar, Vijaykumar Deore, Nilambari Yewalkar
Publikováno v:
Journal of Heterocyclic Chemistry. 44:495-498
We are herein reporting the regioselective synthesis of quinazoline containing novel monoaryl ethers (quinazoline-O-Ar) (3a-3j) at room temperature without any catalyst. From commercially available 2,4-dichloro-6,7-dimethoxyquinazoline (1), 4-chloro
Autor:
Pallavi, Godse, Pramod, Kumar, Nilambari, Yewalkar, Vijaykumar, Deore, Manoj, Lohar, Ramswaroop, Mundada, Amol, Padgaonkar, Sonal, Manohar, Asavari, Joshi, Dimple, Bhatia, Nikesh, Desai, Anagha, Damre, Mandar, Bhonde, Kalpana, Joshi, Rajiv, Sharma, Sanjay, Kumar
Publikováno v:
Anti-cancer agents in medicinal chemistry. 13(9)
Hypoxia-inducible factor-1α (HIF-1α) and signal transducer and activator of transcription 3 (STAT3) are transcription factors and are activated in response to hypoxia. Both HIF-1α and STAT3 regulate various aspects of cancer biology such as cell s
Autor:
Pramod Kumar, Kalpana Joshi, Amol Padgaonkar, Bichismita Sahu, Archana Jalota-Badhwar, Sonal M Manohar, Somesh Sharma, Sanjeev Kumar, Nilambari Yewalkar, Vijaykumar Deore
Publikováno v:
ChemInform. 42
Pyridylpyrimidine based potent and selective inhibitors of HIF-1α are designed and synthesized.
Autor:
Kalpana Joshi, Somesh Sharma, Nilambari Yewalkar, Amol Padgaonkar, Vijaykumar Deore, Pramod Kumar, Sanjeev Kumar, Archana Jalota-Badhwar, Bichismita Sahu, Sonal M Manohar
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(22)
Hypoxia-inducible factor-1α (HIF-1α) is a critical regulatory protein of cellular response to hypoxia, and regulates the transcription of many genes involved in key aspects of cancer biology, including immortalization, maintenance of stem cell pool
Autor:
Vijaykumar Deore, Shruta S. Dadarkar, Pooja Bhatt, Dimple Bhatia, Kumar V.S. Nemmani, Nilesh M. Dagia, Sanjay Kumar, Mandar R. Bhonde, Abhijit Roychowdhury, Ravindra Dattatraya Gupte, Nilambari Yewalkar, Somesh Sharma, Nikesh Desai, Mahesh G. Jadhav, Ram A. Vishwakarma, Aditi Amol Tannu
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(11)
A series of novel cyanopyridyl based molecules ( 1 – 14 ) were designed, synthesized and probed for inhibition of mammalian target of rapamycin (mTOR) activity. Compound 14 was found to be a potent inhibitor of mTOR activity as assessed by enzyme-l
Autor:
Sanjay Kumar, Somesh Sharma, Nilesh M Dagia, Dimple Bhatia, Aditi Amol Tannu, Ram A. Vishwakarma, Mahesh G. Jadhav, Nilambari Yewalkar, Shruta Dadarkar, Vijaykumar Deore, Nikesh Desai, Pooja Bhatt, Ravindra Dattatraya Gupte, Mandar R. Bhonde
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 295(6)
Ulcerative colitis is an autoimmune-inflammatory disease characterized by increased proliferation of colonic epithelial cells, dysregulation of signal transduction pathways, elevated mucosal T cell activation, increased production of proinflammatory
Autor:
Kalpana Joshi, Vijaykumar Deore, Ram A. Vishwakarma, Amol Padgaonkar, Dimple Bhatia, Maggie Joyce Rathos, Mandar R. Bhonde, Manoj V. Lohar, Sanjay Kumar, Ramswaroop Mundada, Nilambari Yewalkar
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(12)
We herein report the design and synthesis of furoquinoline based novel molecules (16–36) and their in vitro multiple targeted inhibitory potency against PI3K/Akt phosphorylation and mTOR using cell based and cell-free kinase assay. In particular, c