Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Nilaksh Gupta"'
Autor:
Seok-Jo Kim, Swarna Bale, Priyanka Verma, Qianqian Wan, Feiyang Ma, Johann E. Gudjonsson, Stanley L. Hazen, Paul W. Harms, Pei-Suen Tsou, Dinesh Khanna, Lam C. Tsoi, Nilaksh Gupta, Karen J. Ho, John Varga
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104669- (2022)
Summary: Intestinal dysbiosis is prominent in systemic sclerosis (SSc), but it remains unknown how it contributes to microvascular injury and fibrosis that are hallmarks of this disease. Trimethylamine (TMA) is generated by the gut microbiome and in
Externí odkaz:
https://doaj.org/article/f9eca232c9634042bf6a7b0a0699f25c
Autor:
Marco Witkowski, Ina Nemet, Hassan Alamri, Jennifer Wilcox, Nilaksh Gupta, Nisreen Nimer, Arash Haghikia, Xinmin S. Li, Yuping Wu, Prasenjit Prasad Saha, Ilja Demuth, Maximilian König, Elisabeth Steinhagen-Thiessen, Tomas Cajka, Oliver Fiehn, Ulf Landmesser, W. H. Wilson Tang, Stanley L. Hazen
Publikováno v:
Nature Medicine. 29:710-718
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3a7a3c4a93074061001cbfb18b06535
https://doi.org/10.1038/s41591-023-02223-9
https://doi.org/10.1038/s41591-023-02223-9
Autor:
Chelsea L. Organ, Zhen Li, Thomas E. Sharp, David J. Polhemus, Nilaksh Gupta, Traci T. Goodchild, W. H. Wilson Tang, Stanley L. Hazen, David J. Lefer
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 10 (2020)
Background Patients at increased risk for coronary artery disease and adverse prognosis during heart failure exhibit increased levels of circulating trimethylamine N‐oxide (TMAO), a metabolite formed in the metabolism of dietary phosphatidylcholine
Externí odkaz:
https://doaj.org/article/22461a42020f413194074c3828bfb2fd
Autor:
John Varga, Karen J. Ho, Paul W. Harms, Nilaksh Gupta, Qianqian Wan, Seokjo Kim, Lam C. Tsoi, Dinesh Khanna, Johann E. Gudjonsson, Swarna Bale, Stanley L. Hazen, Pei-Suen Tsou
Publikováno v:
SSRN Electronic Journal.
Intestinal dysbiosis is prominent in systemic sclerosis (SSc), but it remains unknown if and how it contributes to synchronous microvascular injury and fibrosis that characterize this disease. Trimethylamine (TMA) is generated in the gut and converte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18f7c42f948245f0e115b54c35cc10db
https://doi.org/10.2139/ssrn.3912949
https://doi.org/10.2139/ssrn.3912949
Autor:
David J. Lefer, W.H. Wilson Tang, Traci T. Goodchild, Chelsea L. Organ, Zhen Li, Stanley L. Hazen, Nilaksh Gupta, David J. Polhemus, Thomas E. Sharp
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Patients at increased risk for coronary artery disease and adverse prognosis during heart failure exhibit increased levels of circulating trimethylamine N‐oxide ( TMAO ), a metabolite formed in the metabolism of dietary phosphatidylcholi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ca2919b0570b9952ba9bb6b150d32a
https://pubmed.ncbi.nlm.nih.gov/32390485
https://pubmed.ncbi.nlm.nih.gov/32390485
Autor:
Naseer Sangwan, Stanley L. Hazen, Joseph A. DiDonato, Nilaksh Gupta, Karen J. Ho, Jennifer A. Buffa, Adam B. Roberts, Sarah M. Skye, John Varga, W.H. Wilson Tang, Lin Li
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: Gut microbial metabolism of dietary choline, a nutrient abundant in a Western diet, produces trimethylamine (TMA) and the atherothrombosis- and fibrosis-promoting metabolite TMA-N-oxide (TMAO). Recent clinical and animal studies reveal tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb00cdc6bd842501169533215b7b0e15
https://europepmc.org/articles/PMC7203662/
https://europepmc.org/articles/PMC7203662/
Autor:
Xiaodong Gu, Stanley L. Hazen, Matthew W Russell, Jennifer A. Buffa, Jose C. Garcia-Garcia, Aldons J. Lusis, Nilaksh Gupta, Jodie Michelle Reed, Sarah M. Skye, Zeneng Wang, Alex G Hurd, Bruce S. Levison, David B. Cody, William T. Barrington, Joseph A. DiDonato, Lin Li, Adam B. Roberts, J. Mark Brown, Ashraf Duzan, Xiaoming Fu, Jennifer M. Lang, Alex J Myers, Weifei Zhu, Suguna Rachakonda, Valentin Gogonea
Publikováno v:
Nature Medicine. 24:1407-1417
Trimethylamine N-oxide (TMAO) is a gut microbiota-derived metabolite that enhances both platelet responsiveness and in vivo thrombosis potential in animal models, and TMAO plasma levels predict incident atherothrombotic event risks in human clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d6a342aa36f6aac1ba9b892198df276
https://doi.org/10.1038/s41591-018-0128-1
https://doi.org/10.1038/s41591-018-0128-1
Publikováno v:
Journal of the American College of Cardiology. 77:3400
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f6f6abcbe80a1f019ff7bd43a8fbcd1
https://doi.org/10.1016/s0735-1097(21)04754-9
https://doi.org/10.1016/s0735-1097(21)04754-9
Autor:
Weifei Zhu, Tomas Cajka, Prasenjit Prasad Saha, Amanda E. Ramer-Tait, Nilaksh Gupta, Kymberleigh A. Romano, Lin Li, Michael A. Fischbach, Federico E. Rey, W.H. Wilson Tang, Sathyamangla V. Naga Prasad, Sarah M. Skye, Maradumane L. Mohan, Stanley L. Hazen, Ina Nemet, Yuping Wu, Joseph A. DiDonato, Oliver Fiehn, Masanori Funabashi
Publikováno v:
Cell. 180:862-877.e22
Summary Using untargeted metabolomics (n = 1,162 subjects), the plasma metabolite (m/z = 265.1188) phenylacetylglutamine (PAGln) was discovered and then shown in an independent cohort (n = 4,000 subjects) to be associated with cardiovascular disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aca3a156d8db9f2db3dd569f04782d65
https://doi.org/10.1016/j.cell.2020.02.016
https://doi.org/10.1016/j.cell.2020.02.016
Autor:
J. C. Gregory, Elin Org, Zeneng Wang, Ling Li, Stanley A Hazen, Joseph A. DiDonato, Nilaksh Gupta, Manya Warrier, Rebecca C. Schugar, X. Fu, Jonathan Mark Brown, A. J. Lusis, Diana M. Shih, Jennifer A. Buffa, Weifei Zhu
Publikováno v:
Journal of thrombosis and haemostasis : JTH. 16(9)
Essentials Microbe-dependent production of trimethylamine N-oxide (TMAO) contributes to thrombosis risk. The impact of host flavin monooxygenase 3 (FMO3) modulation on platelet function is unknown. Genetic manipulation of FMO3 in mice alters systemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6fa5e4f7096a2d8aa61d0d07916afcb
https://pubmed.ncbi.nlm.nih.gov/29981269
https://pubmed.ncbi.nlm.nih.gov/29981269