Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Nilah M. Ioannidis"'
Autor:
Pooja Kathail, Richard W. Shuai, Ryan Chung, Chun Jimmie Ye, Gabriel B. Loeb, Nilah M. Ioannidis
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-22 (2024)
Abstract Background A number of deep learning models have been developed to predict epigenetic features such as chromatin accessibility from DNA sequence. Model evaluations commonly report performance genome-wide; however, cis regulatory elements (CR
Externí odkaz:
https://doaj.org/article/da295330cb0b4f5faec4822e64e910e6
Autor:
Ryo Yamamoto, Ryan Chung, Juan Manuel Vazquez, Huanjie Sheng, Philippa L. Steinberg, Nilah M. Ioannidis, Peter H. Sudmant
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Age is a risk factor for many diseases, but the impact of aging on molecular phenotypes is not fully understood. Here, the authors quantify the relative contributions of genetics and aging to gene expression patterns across 27 tissues in humans, show
Externí odkaz:
https://doaj.org/article/89c332f07174466583bcce159c26ab84
Autor:
Nilah M. Ioannidis, Wei Wang, Nicholas A. Furlotte, David A. Hinds, andMe Research Team, Carlos D. Bustamante, Eric Jorgenson, Maryam M. Asgari, Alice S. Whittemore
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Genetic loci linked to susceptibility for the common skin cancer cutaneous squamous cell carcinoma (cSCC) have been identified by genome wide association studies (GWAS). Here, the authors impute gene expression levels from GWAS data to perform a tran
Externí odkaz:
https://doaj.org/article/bc53e2b17a3e44f0b9062dcd5eaac15b
Autor:
Aniketh Janardhan Reddy, Michael H. Herschl, Sathvik Kolli, Amy X. Lu, Xinyang Geng, Aviral Kumar, Patrick D. Hsu, Sergey Levine, Nilah M. Ioannidis
Advances in gene delivery technologies are enabling rapid progress in molecular medicine, but require precise expression of genetic cargo in desired cell types, which is predominantly achieved via a regulatory DNA sequence called a promoter; however,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9e641a78af0c16c2e7d90c51f963f34
https://doi.org/10.1101/2023.02.24.529941
https://doi.org/10.1101/2023.02.24.529941
Publikováno v:
Bioinformatics
Summary Interpreting genetic variants of unknown significance (VUS) is essential in clinical applications of genome sequencing for diagnosis and personalized care. Non-coding variants remain particularly difficult to interpret, despite making up a la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d07274e74a98c9049b10dfab5230fe7d
https://europepmc.org/articles/PMC7575052/
https://europepmc.org/articles/PMC7575052/
Autor:
Eric Jorgenson, David A. Hinds, Nicholas A. Furlotte, Nilah M. Ioannidis, Carlos Bustamante, Wei Wang, Alice S. Whittemore, Maryam M. Asgari
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Nature Communications
Nature Communications
Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer with genetic susceptibility loci identified in recent genome-wide association studies (GWAS). Transcriptome-wide association studies (TWAS) using imputed gene expression levels can iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::488c6adf9c954483c89e6e1f20ed578c
http://link.springer.com/article/10.1038/s41467-018-06149-6
http://link.springer.com/article/10.1038/s41467-018-06149-6
Autor:
Sumit Middha, Graham G. Giles, Anthony M. Musolf, Predrag Radivojac, Johanna Schleutker, Chih-Lin Hsieh, Robert J. MacInnis, Zsofia Kote-Jarai, Christiane Maier, Emily R. Holzinger, Janet L. Stanford, Weiva Sieh, John D. Carpten, Joan E. Bailey-Wilson, Saurabh Baheti, Trevor Hastie, Shannon K. McDonnell, Lisa A. Cannon-Albright, Joseph H. Rothstein, Danielle M. Karyadi, Vikas Pejaver, Elaine A. Ostrander, Diptasri Mandal, Jianfeng Xu, Olivier Cussenot, Daniel J. Schaid, William B. Isaacs, Craig C. Teerlink, Isaac J. Powell, Ethan M. Lange, Nilah M. Ioannidis, Geraldine Cancel-Tassin, William J. Catalona, Qing Li, Alice S. Whittemore, Kathleen A. Cooney, Rosalind A. Eeles, William D. Foulkes, Stephen N. Thibodeau, Fredrik Wiklund, Carlos Bustamante
Publikováno v:
The American Journal of Human Genetics. 99:877-885
Supplemental Data Supplemental Data include one figure and five tables and can be found with this article online at http://dx.doi.org/10.1016/j.ajhg.2016.08.016. Supplemental Data Document S1. Figure S1 and Tables S1–S5 Download Document S2. Articl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca7f9cb869537edaeda45ecd8fa8a0ca
https://doi.org/10.1016/j.ajhg.2016.08.016
https://doi.org/10.1016/j.ajhg.2016.08.016
Autor:
Alice S. Whittemore, Maryam M. Asgari, Eric Jorgenson, Wei Wang, Jacqueline Itnyre, Thomas J. Hoffmann, Nilah M. Ioannidis
Publikováno v:
Journal of Investigative Dermatology. 136:930-937
We report a genome-wide association study of cutaneous squamous cell carcinoma conducted among non-Hispanic white members of the Kaiser Permanente Northern California health care system. The study includes a genome-wide screen of 61,457 members (6,89
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed580d4d4338c2285e836d286c9920d
https://doi.org/10.1016/j.jid.2016.01.013
https://doi.org/10.1016/j.jid.2016.01.013
Autor:
Nilah M. Ioannidis, Eric Jorgenson, Emmanuel Mignot, Alice S. Whittemore, Shadmehr Demehri, Maryam M. Asgari, Wei Wang, Hanna Ollila
Publikováno v:
Cancer immunology, immunotherapy : CII. 67(7)
BACKGROUND: The immune system has been implicated in the pathophysiology of cutaneous squamous cell carcinoma (cSCC) as evidenced by the substantially increased risk of cSCC in immunosuppressed individuals. Associations between cSCC risk and single n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce36ea8af167ca23c8a7216dead0e13
https://pubmed.ncbi.nlm.nih.gov/29754218
https://pubmed.ncbi.nlm.nih.gov/29754218
Publikováno v:
The Journal of investigative dermatology. 138(12)
Cutaneous squamous cell cancers (cSCCs) present an under-recognized health issue among non-Hispanic whites, one that is likely to increase as populations age. cSCC risks vary considerably among non-Hispanic whites, and this heterogeneity indicates th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9454e24cc2d5227528c089410929063
https://pubmed.ncbi.nlm.nih.gov/30472995
https://pubmed.ncbi.nlm.nih.gov/30472995