Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Niladri K Sinha"'
Publikováno v:
PLoS Genetics, Vol 17, Iss 10, p e1009813 (2021)
Translation of messenger RNAs (mRNAs) with premature termination codons produces truncated proteins with potentially deleterious effects. This is prevented by nonsense-mediated mRNA decay (NMD) of these mRNAs. NMD is triggered by ribosomes terminatin
Externí odkaz:
https://doaj.org/article/fa5279b562774fcdb51142e48baba02b
Autor:
Niladri K Sinha, Alban Ordureau, Katharina Best, James A Saba, Boris Zinshteyn, Elayanambi Sundaramoorthy, Amit Fulzele, Danielle M Garshott, Timo Denk, Matthias Thoms, Joao A Paulo, J Wade Harper, Eric J Bennett, Roland Beckmann, Rachel Green
Publikováno v:
eLife, Vol 9 (2020)
Translation of aberrant mRNAs induces ribosomal collisions, thereby triggering pathways for mRNA and nascent peptide degradation and ribosomal rescue. Here we use sucrose gradient fractionation combined with quantitative proteomics to systematically
Externí odkaz:
https://doaj.org/article/900a514023304981b6374d2c536978ff
Autor:
Nathan M. Livingston, Jiwoong Kwon, Oliver Valera, James A. Saba, Niladri K. Sinha, Pranav Reddy, Blake Nelson, Clara Wolfe, Taekjip Ha, Rachel Green, Jian Liu, Bin Wu
SummaryStochasticity has emerged as a mechanism to control gene expression. Much of this so-called “noise” has been attributed to bursting transcription. However, the stochasticity of translation has not similarly been investigated due to a lack
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::459375b7e4e09c4b246b488db5f4fa5f
https://doi.org/10.1101/2022.11.07.515520
https://doi.org/10.1101/2022.11.07.515520
Publikováno v:
PLoS Genetics, Vol 17, Iss 10, p e1009813 (2021)
PLoS Genetics
PLoS Genetics
Translation of messenger RNAs (mRNAs) with premature termination codons produces truncated proteins with potentially deleterious effects. This is prevented by nonsense-mediated mRNA decay (NMD) of these mRNAs. NMD is triggered by ribosomes terminatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5645a0b75714b148b25c53c84d662ed3
https://doaj.org/article/fa5279b562774fcdb51142e48baba02b
https://doaj.org/article/fa5279b562774fcdb51142e48baba02b
Autor:
Timo Denk, Boris Zinshteyn, Amit Fulzele, J. Wade Harper, James A. Saba, Matthias Thoms, Roland Beckmann, Niladri K. Sinha, Joao A. Paulo, Elayanambi Sundaramoorthy, Rachel Green, Katharina Best, Danielle M. Garshott, Eric J. Bennett, Alban Ordureau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26452105cf5a76163746d4eb6742ba84
https://doi.org/10.7554/elife.58828.sa2
https://doi.org/10.7554/elife.58828.sa2
Autor:
Niladri K. Sinha, Brenda L. Bass
Publikováno v:
Methods. 126:54-65
The Dicer family of ribonucleases plays a key role in small RNA-based regulatory pathways by generating short dsRNA fragments that modulate expression of endogenous genes, or protect the host from invasive nucleic acids. Beginning with its initial di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba6578a52c008aa74773392af2b541f
https://doi.org/10.1016/j.ymeth.2017.07.012
https://doi.org/10.1016/j.ymeth.2017.07.012
Autor:
Joseph M. Replogle, Karole N. D’Orazio, Kamena K. Kostova, Kimberly Dickson, Michael Schoof, Kelsey L. Hickey, Niladri K. Sinha, Adam Frost, James Zachery Cogan, Rachel Green, Jonathan S. Weissman
SummaryRibosome-associated Quality Control (RQC) pathways protect cells from toxicity caused by incomplete protein products resulting from translation of damaged or problematic mRNAs. Extensive work in yeast has identified highly conserved mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25e25000fe62daab210995e6f62e3144
Autor:
Karole N. D’Orazio, Niladri K. Sinha, Grant W. Brown, Raphaël Loll-Krippleber, Colin Chih Chien Wu, Rachel Green
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
Translation of problematic sequences in mRNAs leads to ribosome collisions that trigger a sequence of quality control events including ribosome rescue, degradation of the stalled nascent polypeptide via the Ribosome-mediated Quality control Complex (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441da8b546313e0a976dd96d07cd8cad
https://doi.org/10.1101/671099
https://doi.org/10.1101/671099
Autor:
Rachel Green, Jonathan S. Weissman, Michael Schoof, Adam Frost, Karole N. D’Orazio, Marco Jost, Kimberley Dickson, Niladri K. Sinha, Jeffrey A. Hussmann, Joseph M. Replogle, J. Zachery Cogan, Kelsey L. Hickey, Kamena K. Kostova
Publikováno v:
Mol Cell
Ribosome-associated Quality Control (RQC) pathways protect cells from toxicity caused by incomplete protein products resulting from translation of damaged or problematic mRNAs. Extensive work in yeast has identified highly conserved mechanisms that l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae4c007cbc0736a55bdc54ce98ceaccd
https://doi.org/10.1016/j.molcel.2020.07.007
https://doi.org/10.1016/j.molcel.2020.07.007