Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nilabh Chaudhary"'
Publikováno v:
Delivery Strategies for Antisense Oligonucleotide Therapeutics ISBN: 9781315150901
Delivery Strategies for Antisense Oligonucleotide Therapeutics
Delivery Strategies for Antisense Oligonucleotide Therapeutics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5f9f7aa4cff9bbe8dbb19964965ea64
https://doi.org/10.1201/9781315150901-3
https://doi.org/10.1201/9781315150901-3
Autor:
Anusch Peyman, Nilabh Chaudhary, T. Sudhakar Rao, Joshua O. Ojwang, Shawn D. Mustain, Eugen Uhlmann, Hélène B. Marshall, Robert F. Rando, Ganapathi R. Revankar, David A. Walker
Publikováno v:
Nucleosides and Nucleotides. 16:1703-1707
Antisense oligonucleotides containing C-5 hexynyl/propynyl modified pyrimidines were synthesized using solid phase phosphoramidite chemistry. These modified oligonucleotides were found to have significant inhibitory activity against TNFα production
Autor:
Veeraiah Bodepudi, Judith K. Guy-Caffey, Jeffrey S. Bishop, Nilabh Chaudhary, Krishna Jayaraman
Publikováno v:
Journal of Biological Chemistry. 270:31391-31396
Two new polyaminolipids have been synthesized for the purpose of improving cellular uptake of oligonucleotides. The amphipathic compounds are conjugates of spermidine or spermine linked through a carbamate bond to cholesterol. The polyaminolipids are
Autor:
Nilabh Chaudhary, Ganapathi R. Revankar, V. Bodepudi, T. S. Rao, J. Guy-Caffey, Krishna Jayaraman, Ross H. Durland
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 14:951-955
The ability of simple azole nucleosides to promote antiparallel triplex formation at non-homopurine duplex targets was explored. It was also shown that spermidine-cholesterol conjugation is effective in enhancing cellular uptake and stability of olig
Publikováno v:
Antiviral research. 61(3)
Respiratory syncytial virus (RSV) is a major cause of lower respiratory diseases in infants, young children, and the elderly. Ribavirin, the only currently approved drug for the treatment of RSV infections in the U.S., requires high doses to be effec
Autor:
Kristal Domenico, Ira von Carlowitz, Dennis Macejak, Nilabh Chaudhary, Andrew Conrad, Pamela Pavco, Kristi Jensen, Laurent Bellon, Sharon Jamison, Lawrence M. Blatt, Myron J. Tong, Elisabeth Roberts
Publikováno v:
Hepatology (Baltimore, Md.). 31(3)
Ribozymes are catalytic RNA molecules that can be designed to cleave specific RNA sequences. To investigate the potential use of synthetic stabilized ribozymes for the treatment of chronic hepatitis C virus (HCV) infection, we designed and synthesize
Autor:
T. Sudhakar Rao, Shawn D. Mustain, Eugen Uhlmann, Robert F. Rando, Taishin Akiyama, Joshua O. Ojwang, David A. Walker, Michael E. Hogan, Nilabh Chaudhary, Hélène B. Marshall, Anusch Peyman, Ganapathi R. Revankar
Publikováno v:
Biochemistry. 36(20)
Tumor necrosis factor alpha (TNF alpha), a polypeptide produced by activated macrophages, is a highly pleiotropic cytokine which elicits inflammatory and immunological reactions. The binding of TNF alpha to tumor necrosis factor receptor type I (TNFR
Autor:
Michael E. Hogan, Nilabh Chaudhary, Joshua O. Ojwang, Steve Smith, Judith K. Guy-Caffey, Jeffrey S. Bishop, Paul A. Cossum, Robert F. Rando
Publikováno v:
The Journal of biological chemistry. 271(10)
We have identified a potentially therapeutic anti-human immunodeficiency virus (HIV)-1 oligonucleotide composed entirely of deoxyguanosines and thymidines (T30177, also known as AR177: 5'-g.tggtgggtgggtggg.t-3', where asterisk indicates phosphorothio
Autor:
Sang Wook Choi, Nilabh Chaudhary, Swan N. Thung, Howard J. Worman, Neil D. Theise, Prodromos Hytiroglou
Publikováno v:
Human pathology. 24(2)
The nuclear lamina is a meshwork of intermediate filaments adjacent to the inner nuclear membrane that in mammalian cells is predominantly composed of three proteins: lamin A, lamin B, and lamin C. Because lamin A and C (A-type lamins) expression has
Publikováno v:
Biology of the cell. 69(2)
We have characterized human autoimmune polyclonal antibodies reactive with lamin A, a 74 kDa peripheral protein of the nuclear envelope. Unlike other known antibodies to lamin A, the antibodies described here do not crossreact with the structurally r