Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Nikunj Satani"'
Autor:
Nikunj Satani, Kaushik Parsha, Courtney Davis, Adrian Gee, Scott D. Olson, Jaroslaw Aronowski, Sean I. Savitz
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
BackgroundSystemic administration of marrow stromal cells (MSCs) leads to the release of a broad range of factors mediating recovery in rodent stroke models. The release of these factors could depend on the various cell types within the peripheral bl
Externí odkaz:
https://doaj.org/article/4f0c766a1d884f41a21d5af94ad16da2
Autor:
Yasaman Barekatain, Jeffrey J. Ackroyd, Victoria C. Yan, Sunada Khadka, Lin Wang, Ko-Chien Chen, Anton H. Poral, Theresa Tran, Dimitra K. Georgiou, Kenisha Arthur, Yu-Hsi Lin, Nikunj Satani, Elliot S. Ballato, Eliot I. Behr, Ana C. deCarvalho, Roel G. W. Verhaak, John de Groot, Jason T. Huse, John M. Asara, Raghu Kalluri, Florian L. Muller
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The metabolite methylthioadenosine (MTA) inhibits PRMT5. Therefore, MTA accumulation due to MTA phosphorylase (MTAP) deletion has been proposed as a vulnerability for PRMT5-targeted therapy in cancer. Here, the authors show that MTA does not accumula
Externí odkaz:
https://doaj.org/article/52cd1479712f4a068ae698d7e4c9858e
Autor:
Sujan T. Reddy, Nikunj Satani, Jennifer E. S. Beauchamp, Sudhakar Selvaraj, Suja S. Rajan, Mohammad H. Rahbar, Amirali Tahanan, Sori Kim, Travis Holder, Xiaoqian Jiang, Luyao Chen, Haris Kamal, Hari Kishan R. Indupuru, Tzu‐Ching Wu, Sean I. Savitz
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 4, Pp 929-937 (2021)
Abstract Objective To review the global impact of the COVID‐19 pandemic on stroke care‐metrics and report data from a health system in Houston. Methods We performed a meta‐analysis of the published literature reporting stroke admissions, intrac
Externí odkaz:
https://doaj.org/article/9eefd40c56e046a7ad8957169088120a
Autor:
Nikunj Satani, Xu Zhang, Kaavya Giridhar, Natalia Wewior, Chunyan Cai, Jaroslaw Aronowski, Sean I. Savitz
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background and Purpose: Marrow stromal cells (MSCs) are being tested in clinical trials for stroke patients. MSCs appear to promote recovery through secretomes that promote modulation of immune cells, including myeloid phagocytes. Many stroke patient
Externí odkaz:
https://doaj.org/article/5b05cc2fb48b4ba6abde7c19da996301
Autor:
Nikunj Satani, Kaavya Giridhar, Chunyan Cai, Natalia Wewior, Dominique D. Norris, Jaroslaw Aronowski, Sean I. Savitz
Publikováno v:
Stem Cells International, Vol 2020 (2020)
Marrow stromal cells (MSCs) are in different stages of clinical trials for stroke patients. MSCs are proposed to promote recovery through the release of secretomes that modulate the function of beneficial immune cells. The majority of stroke patients
Externí odkaz:
https://doaj.org/article/c1a53217612f4f7bb981056b7c93f4d6
Autor:
Rina M. Mbofung, Jodi A. McKenzie, Shruti Malu, Min Zhang, Weiyi Peng, Chengwen Liu, Isere Kuiatse, Trang Tieu, Leila Williams, Seram Devi, Emily Ashkin, Chunyu Xu, Lu Huang, Minying Zhang, Amjad H. Talukder, Satyendra C. Tripathi, Hiep Khong, Nikunj Satani, Florian L. Muller, Jason Roszik, Timothy Heffernan, James P. Allison, Gregory Lizee, Sam M. Hanash, David Proia, Rodabe Amaria, R. Eric Davis, Patrick Hwu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Many patients fail to respond to T cell based immunotherapies. Here, the authors, through a high-throughput screening, identify HSP90 inhibitors as a class of preferred drugs for treatment combination with immunotherapy.
Externí odkaz:
https://doaj.org/article/51b2a4e16a0b435cabee2477f3975980
Autor:
Nikunj Satani, Chunyan Cai, Kaavya Giridhar, Daryl McGhiey, Sarah George, Kaushik Parsha, Duyen M. Nghiem, Krystal S. Valenzuela, Jenny Riecke, Farhaan S. Vahidy, Sean I. Savitz
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Background: Following extensive, positive results in pre-clinical experiments, Bone Marrow Derived-Mesenchymal Stromal Cells (BM-MSCs) are now being tested as a novel therapy for ischemic stroke in ongoing clinical trials. However, multiple critical
Externí odkaz:
https://doaj.org/article/f886f5fca652435fad9b397645db4ff7
Autor:
Muhammad E. Haque, Refaat E. Gabr, Khader M. Hasan, Sarah George, Octavio D. Arevalo, Alicia Zha, Susan Alderman, Jerome Jeevarajan, Manual F. Mas, Xu Zhang, Nikunj Satani, Elliott R. Friedman, Clark W. Sitton, Sean Savitz
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Purpose: Ongoing post-stroke structural degeneration and neuronal loss preceding neuropsychological symptoms such as cognitive decline and depression are poorly understood. Various substructures of the limbic system have been linked to cognitive impa
Externí odkaz:
https://doaj.org/article/b2f4aed25c764fe6a031b562d884f106
Publikováno v:
Cells, Vol 10, Iss 4, p 767 (2021)
Ischemic stroke is a debilitating disease and one of the leading causes of long-term disability. During the early phase after ischemic stroke, the blood-brain barrier (BBB) exhibits increased permeability and disruption, leading to an influx of immun
Externí odkaz:
https://doaj.org/article/133606800dc6446eb0260b433e3a1891
Autor:
Federica Pisaneschi, Yu-Hsi Lin, Paul G. Leonard, Nikunj Satani, Victoria C. Yan, Naima Hammoudi, Sudhir Raghavan, Todd M. Link, Dimitra K. Georgiou, Barbara Czako, Florian L. Muller
Publikováno v:
Molecules, Vol 24, Iss 13, p 2510 (2019)
We recently reported that SF2312 ((1,5-dihydroxy-2-oxopyrrolidin-3-yl)phosphonic acid), a phosphonate antibiotic with a previously unknown mode of action, is a potent inhibitor of the glycolytic enzyme, Enolase. SF2312 can only be synthesized as a ra
Externí odkaz:
https://doaj.org/article/e2e793ae82144bf6a2f77eea61824b34