Visualisation of drug distribution in skin using correlative optical spectroscopy and mass spectrometry imaging

Autor: Belsey, Natalie A., Dexter, Alex, Vorng, Jean-Luc, Tsikritsis, Dimitrios, Nikula, Chelsea J., Murta, Teresa, Tiddia, Maria-Vitalia, Zhang, Junting, Gurdak, Elzbieta, Trindade, Gustavo F., Gilmore, Ian S., Page, Leanne, Roper, Clive S., Guy, Richard H., Bettex, Mila Boncheva

Publikováno v: In Journal of Controlled Release December 2023 364:79-89

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Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target.

Autor: Vande Voorde J; Cancer Research UK Beatson Institute, Glasgow, UK. j.vandevoorde@beatson.gla.ac.uk., Steven RT; National Physical Laboratory, London, UK., Najumudeen AK; Cancer Research UK Beatson Institute, Glasgow, UK., Ford CA; Cancer Research UK Beatson Institute, Glasgow, UK., Dexter A; National Physical Laboratory, London, UK., Gonzalez-Fernandez A; National Physical Laboratory, London, UK., Nikula CJ; National Physical Laboratory, London, UK., Xiang Y; Department of Metabolism Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK., Ford L; Department of Metabolism Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK., Maneta Stavrakaki S; Department of Metabolism Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK., Gilroy K; Cancer Research UK Beatson Institute, Glasgow, UK., Zeiger LB; Cancer Research UK Beatson Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Pennel K; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Hatthakarnkul P; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Elia EA; National Physical Laboratory, London, UK., Nasif A; National Physical Laboratory, London, UK., Murta T; National Physical Laboratory, London, UK., Manoli E; Department of Metabolism Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK., Mason S; Department of Metabolism Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK., Gillespie M; Cancer Research UK Beatson Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Lannagan TRM; Cancer Research UK Beatson Institute, Glasgow, UK., Vlahov N; Cancer Research UK Beatson Institute, Glasgow, UK., Ridgway RA; Cancer Research UK Beatson Institute, Glasgow, UK., Nixon C; Cancer Research UK Beatson Institute, Glasgow, UK., Raven A; Cancer Research UK Beatson Institute, Glasgow, UK., Mills M; Cancer Research UK Beatson Institute, Glasgow, UK., Athineos D; Cancer Research UK Beatson Institute, Glasgow, UK., Kanellos G; Cancer Research UK Beatson Institute, Glasgow, UK., Nourse C; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Gay DM; Cancer Research UK Beatson Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK.; Københavns Universitet, BRIC, Copenhagen, Denmark., Hughes M; Cancer Research UK Beatson Institute, Glasgow, UK., Burton A; National Physical Laboratory, London, UK., Yan B; National Physical Laboratory, London, UK., Sellers K; The Francis Crick Institute, London, UK.; Rheos Medicines, Cambridge, MA, USA., Wu V; Department of Metabolism Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK., De Ridder K; Department of Human Genetics, University of Leuven, KU Leuven, Leuven, Belgium., Shokry E; Cancer Research UK Beatson Institute, Glasgow, UK., Huerta Uribe A; Cancer Research UK Beatson Institute, Glasgow, UK., Clark W; Cancer Research UK Beatson Institute, Glasgow, UK., Clark G; Cancer Research UK Beatson Institute, Glasgow, UK., Kirschner K; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Thienpont B; Department of Human Genetics, University of Leuven, KU Leuven, Leuven, Belgium., Li VSW; The Francis Crick Institute, London, UK., Maddocks ODK; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Barry ST; Bioscience, Early Oncology, AstraZeneca, Cambridge, UK., Goodwin RJA; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK.; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Kinross J; Department of Metabolism Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK., Edwards J; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Yuneva MO; The Francis Crick Institute, London, UK., Sumpton D; Cancer Research UK Beatson Institute, Glasgow, UK., Takats Z; Department of Metabolism Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.; Biological Mass Spectrometry, Rosalind Franklin Institute, Didcot, UK., Campbell AD; Cancer Research UK Beatson Institute, Glasgow, UK., Bunch J; National Physical Laboratory, London, UK.; Department of Metabolism Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.; Biological Mass Spectrometry, Rosalind Franklin Institute, Didcot, UK., Sansom OJ; Cancer Research UK Beatson Institute, Glasgow, UK. o.sansom@beatson.gla.ac.uk.; School of Cancer Sciences, University of Glasgow, Glasgow, UK. o.sansom@beatson.gla.ac.uk.

Publikováno v: Nature metabolism [Nat Metab] 2023 Aug; Vol. 5 (8), pp. 1303-1318. Date of Electronic Publication: 2023 Aug 14.