Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Nikos Pinotsis"'
Autor:
Nikos Pinotsis, Anna Krüger, Nicolas Tomas, Spyros D. Chatziefthymiou, Claudia Litz, Simon Arnold Mortensen, Mamadou Daffé, Hedia Marrakchi, Garabed Antranikian, Matthias Wilmanns
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The identification and characterization of enzyme function is largely lacking behind the rapidly increasing availability of large numbers of sequences and associated high-resolution structures. This is often hampered by lack of knowledge on
Externí odkaz:
https://doaj.org/article/8dd984e6035b406ba13061303ee8359a
Autor:
Christopher A. Waudby, Saul Alvarez-Teijeiro, E. Josue Ruiz, Simon Suppinger, Nikos Pinotsis, Paul R. Brown, Axel Behrens, John Christodoulou, Anastasia Mylona
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Phosphorylation at multiple sites is a major regulatory mechanism in cellular signalling. Here, the authors show that multisite phosphorylation of the c-JUN transcription factor by the JNK kinase exhibits intrinsic kinetics that allow a precise and t
Externí odkaz:
https://doaj.org/article/449495f650ce4cc3a30aa7a2b8fcd3ce
Publikováno v:
Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-15 (2022)
Abstract Transversal structural elements in cross-striated muscles, such as the M-band or the Z-disc, anchor and mechanically stabilize the contractile apparatus and its minimal unit—the sarcomere. The ability of proteins to target and interact wit
Externí odkaz:
https://doaj.org/article/f52d96bd3dcc4be59a31e7d7f029ed22
Autor:
Nikos Pinotsis, Spyros D Chatziefthimiou, Felix Berkemeier, Fabienne Beuron, Irene M Mavridis, Petr V Konarev, Dmitri I Svergun, Edward Morris, Matthias Rief, Matthias Wilmanns
Publikováno v:
PLoS Biology, Vol 10, Iss 2, p e1001261 (2012)
Active muscles generate substantial mechanical forces by the contraction/relaxation cycle, and, to maintain an ordered state, they require molecular structures of extraordinary stability. These forces are sensed and buffered by unusually long and ela
Externí odkaz:
https://doaj.org/article/91f96adf3c0644e590ec036fba6a169c
Autor:
Grace Q. Gong, Benoit Bilanges, Ben Allsop, Glenn R. Masson, Victoria Roberton, Trevor Askwith, Sally Oxenford, Ralitsa R. Madsen, Sarah E. Conduit, Dom Bellini, Martina Fitzek, Matt Collier, Osman Najam, Zhenhe He, Ben Wahab, Stephen H. McLaughlin, A. W. Edith Chan, Isabella Feierberg, Andrew Madin, Daniele Morelli, Amandeep Bhamra, Vanesa Vinciauskaite, Karen E. Anderson, Silvia Surinova, Nikos Pinotsis, Elena Lopez-Guadamillas, Matthew Wilcox, Alice Hooper, Chandni Patel, Maria A. Whitehead, Tom D. Bunney, Len R. Stephens, Phillip T. Hawkins, Matilda Katan, Derek M. Yellon, Sean M. Davidson, David M. Smith, James B. Phillips, Richard Angell, Roger L. Williams, Bart Vanhaesebroeck
Publikováno v:
Nature. 618:159-168
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8f8e36156cc591a3aec34b2fffc9688
https://doi.org/10.1038/s41586-023-05972-2
https://doi.org/10.1038/s41586-023-05972-2
In mitochondria, complex IV (CIV) can be found as a monomer, a dimer or in association with other respiratory complexes. The atomic structure of the yeast S. cerevisiae CIV in a supercomplex (SC) with complex III (CIII) pointed to a region of signifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b54a295dfd7f2b99ef53f25b62c944dc
https://eprints.bbk.ac.uk/id/eprint/48650/16/48650b.pdf
https://eprints.bbk.ac.uk/id/eprint/48650/16/48650b.pdf
Autor:
Shumeng Ma, Shymaa Damfo, Jiaqi Lou, Nikos Pinotsis, Matthew W. Bowler, Shozeb Haider, Frank Kozielski
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 20; Pages: 12448
The regular reappearance of coronavirus (CoV) outbreaks over the past 20 years has caused significant health consequences and financial burdens worldwide. The most recent and still ongoing novel CoV pandemic, caused by Severe Acute Respiratory Syndro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e5a67add5d75976d10d0e9f71bca12
https://pubmed.ncbi.nlm.nih.gov/36293303
https://pubmed.ncbi.nlm.nih.gov/36293303
Publikováno v:
Science advances. 8(25)
PLCγ enzymes are autoinhibited in resting cells and form key components of intracellular signaling that are also linked to disease development. Insights into physiological and aberrant activation of PLCγ require understanding of an active, membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca057e2049cc901ff4e959f407c2b973
https://pubmed.ncbi.nlm.nih.gov/35749497
https://pubmed.ncbi.nlm.nih.gov/35749497
Autor:
Nikos Pinotsis, Anna Krüger, Nicolas Tomas, Spyros D Chatziefthymiou, Claudia Litz, Simon Arnold Mortensen, Mamadou Daffé, Hedia Marrakchi, Garabed Antranikian, Matthias Wilmanns
The identification and characterization of enzyme function is lacking behind the rapidly increasing availability of large numbers of sequences and associated high-resolution structures. This often hampered by lack of knowledge on in vivo relevant sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3133a276920c1ba566a29368c180f2bd
https://doi.org/10.1101/2022.04.07.487456
https://doi.org/10.1101/2022.04.07.487456
Autor:
Lorena Zuliani-Alvarez, Morten L. Govasli, Jane Rasaiyaah, Chris Monit, Stephen O. Perry, Rebecca P. Sumner, Simon McAlpine-Scott, Claire Dickson, K. M. Rifat Faysal, Laura Hilditch, Richard J. Miles, Frederic Bibollet-Ruche, Beatrice H. Hahn, Till Boecking, Nikos Pinotsis, Leo C. James, David A. Jacques, Greg J. Towers
Publikováno v:
nature microbiology
Nature microbiology 7(11), 1762-1776 (2022). doi:10.1038/s41564-022-01247-0
Nature microbiology 7(11), 1762-1776 (2022). doi:10.1038/s41564-022-01247-0
Nature microbiology 7(11), 1762 - 1776 (2022). doi:10.1038/s41564-022-01247-0
Of the 13 known independent zoonoses of simian immunodeficiency viruses to humans, only one, leading to human immunodeficiency virus (HIV) type 1(M) has become pandemi
Of the 13 known independent zoonoses of simian immunodeficiency viruses to humans, only one, leading to human immunodeficiency virus (HIV) type 1(M) has become pandemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::532c5c7f01b92c834d6861fa65e0d481