Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Nikos G. Oikonomakos"'
Autor:
Maria Kontou, H. S. Tsitoura, Louise N. Johnson, K.R. Acharya, C. J. F. Bichard, K.A. Watson, Spyros E. Zographos, Demetres D. Leonidas, E. P. Mitchell, George W. J. Fleet, Nikos G. Oikonomakos, Jong Chan Son
alpha-D-glucose is a weak inhibitor (Ki = 1.7 mM) of glycogen phosphorylase (GP) and acts as physiological regulator of hepatic glycogen metabolism; it binds to GP at the catalytic site and stabilizes the inactive T state of the enzyme promoting the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b4e8773c0f89d62eb8d10ee6f38a0b
https://doi.org/10.1007/bf03188920
https://doi.org/10.1007/bf03188920
Autor:
Mary Gregoriou, Carmen de la Fuente, Katerina E. Tsitsanou, Louise N. Johnson, Nikos G. Oikonomakos, K.A. Watson, Thomas Martin Krulle, George W. J. Fleet, Spyros E. Zographos
Publikováno v:
Synlett 2(Feb1997):211-213
Journal URL: http://www.thieme-connect.com/ejournals/toc/synlett
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad68b061b0a97a76ae66ffe44728b72
https://ora.ox.ac.uk/objects/uuid:f14027a0-3507-465d-8027-631f3c47a4b7
https://ora.ox.ac.uk/objects/uuid:f14027a0-3507-465d-8027-631f3c47a4b7
Autor:
Niovi Santama, Nikos G. Oikonomakos, Angus I. Lamond, Christina E. Drakou, Carsten W. Lederer, Anna Malekkou, Joseph Hayes, Spyros E. Zographos, Demetres D. Leonidas
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 80:206-220
Human coilin interacting nuclear ATPase protein (hCINAP) directly interacts with coilin, a marker protein of Cajal Bodies (CBs), nuclear organelles involved in the maturation of small nuclear ribonucleoproteins UsnRNPs and snoRNPs. hCINAP has previou
Autor:
Demetres D. Leonidas, Nikos G. Oikonomakos, George N. Oikonomakos, Maria Despoina Charavgi, Spyros E. Zographos, Evangelia D. Chrysina, K.-M. Alexacou, Éva Bokor, László Somsák
Publikováno v:
Tetrahedron: Asymmetry. 20:733-740
Per-O-acetylated β- d -glucopyranosyl azide was transformed into an intermediate iminophosphorane by PMe 3 which was then acylated to N -acyl-β- d -glucopyranosylamines. The same azide and substituted acetylenes gave 1-(β- d -glucopyranosyl)-4-sub
Autor:
Demetres D. Leonidas, Swagata Dasgupta, Anirban Samanta, Spyros E. Zographos, Tanmaya Pathak, Nikos G. Oikonomakos
Publikováno v:
Journal of Medicinal Chemistry. 52:932-942
Six 5'-deoxy-5'-morpholine, piperidine, and pyrrolidine of pyrimidine nucleosides have been synthesized and characterized. Their inhibitory action to ribonuclease A has been studied by biochemical analysis and X-ray crystallography. These compounds a
Autor:
Nicolas Boisset, Catherine Vénien-Bryan, Nikos G. Oikonomakos, Slavica Jonic, Nicolas Bischler, Louise N. Johnson, Vasiliki Skamnaki, Nick Brown
Publikováno v:
Structure
Structure, Elsevier (Cell Press), 2009, 17, pp.117-127. ⟨10.1016/j.str.2008.10.013⟩
Structure(London, England:1993)
Structure, 2009, 17, pp.117-127. ⟨10.1016/j.str.2008.10.013⟩
Structure, Elsevier (Cell Press), 2009, 17, pp.117-127. ⟨10.1016/j.str.2008.10.013⟩
Structure(London, England:1993)
Structure, 2009, 17, pp.117-127. ⟨10.1016/j.str.2008.10.013⟩
Phosphorylase kinase (PhK) coordinates hormonal and neuronal signals to initiate the breakdown of glycogen. The enzyme catalyzes the phosphorylation of inactive glycogen phosphorylase b (GPb), resulting in the formation of active glycogen phosphoryla
Autor:
Bale M. Swamy, Demetres D. Leonidas, Nikos G. Oikonomakos, Sathisha J. Gonchigar, George N. Hatzopoulos, Spyros E. Zographos, Shashikala R. Inamdar, Vishwanath B. Chachadi
Publikováno v:
Journal of Molecular Biology. 368:1145-1161
The crystal structure of a novel fungal lectin from Sclerotium rolfsii (SRL) in its free form and in complex with N-acetyl-d-galactosamine (GalNAc) and N-acetyl- d -glucosamine (GlcNAc) has been determined at 1.1 A, 2.0 A, and 1.7 A resolution, respe
Autor:
Evangelia D. Chrysina, Magda Kosmopoulou, C. Tiraidis, Guo-Rong Chen, Li He, Nikos G. Oikonomakos, Jean-Pierre Praly, Marcelle Tanoh, Demetres D. Leonidas, Yun Zhi Zhang
Publikováno v:
European Journal of Organic Chemistry. 2007:596-606
Penta-O-acetyl-β-D-glycopyranoses and 1,4-dimethoxybenzene led selectively by electrophilic substitution to C-β-D-glycopyranosyl-1,4-dimethoxybenzenes which were converted by simple and efficient reactions (oxidation, reduction and deacetylation) t
Autor:
Josephine Sarrou, Joseph Hayes, Vassiliki T. Skamnaki, Nicolas Bischler, Alexios-Leandros Skaltsounis, Demetres D. Leonidas, Jaida Begum, Colin Moffatt, Nikos G. Oikonomakos
Publikováno v:
Journal of molecular graphicsmodelling. 61
Phosphorylase kinase (PhK) has been linked with a number of conditions such as glycogen storage diseases, psoriasis, type 2 diabetes and more recently, cancer (Camus S. et al., Oncogene 2012, 31, 4333). However, with few reported structural studies o
Autor:
Yiannis Elemes, Constantinos Sakarellos, Loranne Agius, Nikos G. Oikonomakos, C. Tiraidis, Minas Ganotidis, Catherine Arden, Laura J. Hampson, Magda Kosmopoulou, Demetres D. Leonidas
Publikováno v:
Bioorganic & Medicinal Chemistry 14:23(Dec2006):7835-7845
The bioactivity in hepatocytes of glycogen phosphorylase inhibitors that bind to the active site, the allosteric activator site and the indole carboxamide site has been described. However, the pharmacological potential of the purine nucleoside inhibi