Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Nikolina Kutinová-Canová"'
Autor:
Martin Šíma, Nikolina Kutinová-Canová, Pavel Ryšánek, Jana Hořínková, Denisa Moškořová, Ondřej Slanař
Publikováno v:
Prague Medical Report, Vol 120, Iss 1, Pp 5-9 (2019)
Data on gastric pH in rats to be used in preclinical models for pH-dependent drug absorption are still limited or contradictory. The aim of this study was to describe gastric pH in rats at fasted state and to evaluate its changes induced by pentagast
Externí odkaz:
https://doaj.org/article/36acc845af964e239dfff7493a285d1c
Autor:
Nikolina Kutinová Canová, J Pozniak, Ondřej Slanař, Martin Šíma, Tereza Boleslavská, Tomas Grus, Jan Bosák, Jana Královičová, Tomáš Křížek, Petr Kozlík, František Štěpánek, Pavel Ryšánek, Peter Lukáč, Jaroslava Roušarová
Publikováno v:
British Journal of Pharmacology. 178:4663-4674
Background and purpose Lymphatic transport of drugs after oral administration is an important mechanism for absorption of highly lipophilic compounds. Direct measurement in lymph duct cannulated animals is the gold standard method, but non-invasive c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c535a3e9d4072a2f81b6be263f605e
https://doi.org/10.1111/bph.15644
https://doi.org/10.1111/bph.15644
Autor:
Nikolina Kutinová Canová, Martin Šíma, Tomáš Křížek, Jan Bosák, František Štěpánek, Josef Beranek, Svatopluk Světlík, Ondřej Dammer, Tereza Boleslavská, Ondřej Slanař, Pavel Žvátora, Petr Kozlík
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 151:81-90
Abiraterone acetate is a potent drug used for the treatment of metastatic castration resistant prostate cancer. However, currently marketed product containing crystalline abiraterone acetate exhibits strong positive food effect which results in stric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9f5ed54eda6a144d1d5f0751dec85cb
https://doi.org/10.1016/j.ejpb.2020.04.005
https://doi.org/10.1016/j.ejpb.2020.04.005
Publikováno v:
European journal of pharmacology. 921
Currently, non-alcoholic fatty liver disease (NAFLD) progressing into chronic non-alcoholic steatohepatitis (NASH), liver cirrhosis, and eventually hepatocellular cancer has emerged as an epidemiological concern due to lack of proven treatment. Our r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0833eae48210207b254f01564cd49894
https://pubmed.ncbi.nlm.nih.gov/35219732
https://pubmed.ncbi.nlm.nih.gov/35219732
Autor:
null Anamika, G. Anderson, Sankarathi Balaiya, Sanjay K. Banerjee, Ariela Benigni, M. Benito, Nady Braidy, J. Burillo, Yirui Cheng, Partha Dabke, Anibh M. Das, Ryan A. Denu, D. Ezhilarasan, Hassan Farghali, Irene Fernández-Duran, Vladimir I. Fisinin, C. González-Blanco, C. Guillén, Qing Han, Rüdiger Hardeland, Peiman Hematti, B. Jiménez, Mighty Kgalalelo Kemelo, Archita Khanna, Hajime Kobayashi, Ivan I. Kochish, Vitaly K. Koltover, Takanori Kumai, Nikolina Kutinová Canová, Shin-Hae Lee, M. Maes, Kenneth Maiese, P. Marqués, Kyung-Jin Min, Sneha Mishra, Brian J. Morris, M. Najimi, Bugga Paramesha, Luca Perico, Venkatraman Ravi, Ken Shinmura, Tatjana A. Skipa, Shu Somemura, Nagalingam Ravi Sundaresan, Peter F. Surai, Dariusz Szukiewicz, Ko Terauchi, Surendra Kumar Trigun, Alejandro Vaquero, Berta N. Vazquez, Maria Villalva, Mateusz Wątroba, Weiliang Xia, Tsunehisa Yamamoto, Kazuo Yudoh, Naoko Yui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8450f7ea5a25222ad57392e090607e4a
https://doi.org/10.1016/b978-0-12-814118-2.00030-6
https://doi.org/10.1016/b978-0-12-814118-2.00030-6
Publikováno v:
Sirtuin Biology in Medicine ISBN: 9780128141182
Xenobiotic-induced hepatotoxicity is a particularly important research field for therapeutics. There are numerous hepatotoxins but a limited number of hepatoprotective drugs. Oxidative stress plays a key role in hepatotoxicity. Over the past decade,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe910a526a66d7f6630dc616bfb0ad4e
https://doi.org/10.1016/b978-0-12-814118-2.00014-8
https://doi.org/10.1016/b978-0-12-814118-2.00014-8
Autor:
Jaroslava Roušarová, Ondřej Dammer, Tereza Boleslavská, Josef Beranek, Ondřej Slanař, Petr Kozlík, Martin Krov, Pavel Žvátora, Ondřej Rychecký, Jana Hořínková, František Štěpánek, Tomáš Křížek, Pavel Ryšánek, Martin Šíma, Nikolina Kutinová Canová
Publikováno v:
The AAPS journal. 22(6)
Abiraterone acetate has limited bioavailability in the fasted state and exhibits a strong positive food effect. We present a novel formulation concept based on the so-called oil marbles (OMs) and show by in vitro and in vivo experiments that the food
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5f84fafaf949c3edce24dea3849c0f
https://pubmed.ncbi.nlm.nih.gov/32978690
https://pubmed.ncbi.nlm.nih.gov/32978690
Publikováno v:
European Journal of Pharmacology. 873:172973
Multiple sclerosis (MS) is a neurologic autoimmune disorder featured by chronic inflammation of the central nervous system, demyelination and axonal damage. Recently, the term "oxinflammation" has been proposed to depict the vicious circle of chronic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7cd99dd9448539aa6b2517e19ddc0f8
https://doi.org/10.1016/j.ejphar.2020.172973
https://doi.org/10.1016/j.ejphar.2020.172973
Autor:
Aneta Pierzynová, Hassan Farghali, Tomáš Kučera, Nikolina Kutinová Canová, Mighty Kgalalelo Kemelo
Publikováno v:
Chemico-biological interactions. 269
The present study was designed to evaluate the therapeutic potential of quercetin in a sub-chronic model of hepatotoxicity. The roles of putative antioxidant enzymes, sirtuin 1 (SIRT1) and heme oxygenase 1 (HO-1), in hepatoprotection were also addres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4650510106c7086de46c1bcf456080c
https://pubmed.ncbi.nlm.nih.gov/28347707
https://pubmed.ncbi.nlm.nih.gov/28347707
Publikováno v:
Fitoterapia. 87:20-26
The objective of this study was to evaluate potential hepatoprotective capabilities of quercetin in relation to its modulation of the HO-1 and NOS-2 activities in an experimental model of fulminant liver failure. Liver insult was induced by in vivo a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89f520fb60da2b23405a77df1b53874a
https://doi.org/10.1016/j.fitote.2013.03.016
https://doi.org/10.1016/j.fitote.2013.03.016