Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Nikoleta Psatha"'
Autor:
Carmen Bravo González-Blas, Irina Matetovici, Hanne Hillen, Ibrahim Ihsan Taskiran, Roel Vandepoel, Valerie Christiaens, Leticia Sansores-García, Elisabeth Verboven, Gert Hulselmans, Suresh Poovathingal, Jonas Demeulemeester, Nikoleta Psatha, David Mauduit, Georg Halder, Stein Aerts
Cell type identity is encoded by gene regulatory networks (GRN), in which transcription factors (TFs) bind to enhancers to regulate target gene expression. In the mammalian liver, lineage TFs have been characterized for the main cell types, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95e9f9ff0c29adecbe4774fcbe8d6a24
https://doi.org/10.1101/2022.12.08.519575
https://doi.org/10.1101/2022.12.08.519575
Autor:
Laurie J. Reitsema, Alissa Mittnik, Britney Kyle, Giulio Catalano, Pier Francesco Fabbri, Adam C. S. Kazmi, Katherine L. Reinberger, Luca Sineo, Stefano Vassallo, Rebecca Bernardos, Nasreen Broomandkhoshbacht, Kim Callan, Francesca Candilio, Olivia Cheronet, Elizabeth Curtis, Daniel Fernandes, Martina Lari, Ann Marie Lawson, Matthew Mah, Swapan Mallick, Kirsten Mandl, Adam Micco, Alessandra Modi, Jonas Oppenheimer, Kadir Toykan Özdogan, Nadin Rohland, Kristin Stewardson, Stefania Vai, Chiara Vergata, J. Noah Workman, Fatma Zalzala, Valentina Zaro, Alessandro Achilli, Achilles Anagnostopoulos, Cristian Capelli, Varnavas Constantinou, Hovirag Lancioni, Anna Olivieri, Anastasia Papadopoulou, Nikoleta Psatha, Ornella Semino, John Stamatoyannopoulos, Ioanna Valliannou, Evangelia Yannaki, Iosif Lazaridis, Nick Patterson, Harald Ringbauer, David Caramelli, Ron Pinhasi, David Reich
Publikováno v:
Proceedings of the National Academy of Sciences (PNAS)
Trade and colonization caused an unprecedented increase in Mediterranean human mobility in the first millennium BCE. Often seen as a dividing force, warfare is in fact another catalyst of culture contact. We provide insight into the demographic dynam
Autor:
Maria Alvanou, Memnon Lysandrou, Panayota Christophi, Nikoleta Psatha, Alexandros Spyridonidis, Anastasia Papadopoulou, Evangelia Yannaki
Publikováno v:
Cancers. 15:1935
T-cell-based, personalized immunotherapy can nowadays be considered the mainstream treatment for certain blood cancers, with a high potential for expanding indications. Chimeric antigen receptor T cells (CAR-Ts), an ex vivo genetically modified T-cel
Autor:
Hongjie Wang, André Lieber, Zsuzsanna Izsvák, Thalia Papayannopoulou, Angeliki Koufali, Evangelia Yannaki, Chang Li, Achilles Anagnostopoulos, Chrysi Kapsali, Afrodite Georgakopoulou, Nikoleta Psatha
Publikováno v:
Blood. 132:2193-2193
To overcome the cost and complexity of current thalassemia ex vivogene therapy protocols, we developed a minimally invasive and readily translatable approach for in vivo HSC gene delivery which abrogates the need for HSC leukapheresis, CD34+ cell sel
Autor:
Minas Arsenakis, Evangelia Athanasiou, Achilles Anagnostopoulos, Panayotis Kaloyannidis, Varnavas Constantinou, Nikoleta Psatha, Ioannis Batsis, Athanasia Tasouli, Anastasia Papadopoulou, Evangelia Yannaki, Athanasios Fassas, Garyfalia Karponi
Publikováno v:
Human Gene Therapy. 21:299-310
Granulocyte colony-stimulating factor (G-CSF)-mobilized blood stem cells may become the preferable source of hematopoietic stem cells (HSCs) for gene therapy because of the higher yield of cells compared with conventional bone marrow harvesting. A G-
Autor:
André Lieber, Demetri Dalas, Hongjie Wang, George Stamatoyannopoulos, Chang Li, Nikoleta Psatha, Thalia Papayannopoulou
Publikováno v:
Blood. 130:947-947
Thalassemia or sickle cell patients with increased fetal hemoglobin have an ameliorated clinical picture up to transfusion independency. Genome editing with targeted nucleases of the γ-globin silencer BCL11a or of the HBG promoter has been shown to
Autor:
Evangelia Yannaki, Achilles Anagnostopoulos, Panayotis Baliakas, Minas Arsenakis, Athanasios Siametis, Nikoleta Psatha, Evangelia Athanasiou, Eleni Sgouramali, Varnavas Constantinou, Antonios Gkountis, George Stamatoyannopoulos, Thalia Papayannopoulou
Publikováno v:
Human gene therapy methods. 25(6)
High numbers of genetically modified hematopoietic stem cells (HSCs) equipped with enhanced engrafting potential are required for successful stem cell gene therapy. By using thalassemia as a model, we investigated the functional properties of hematop
Publikováno v:
Molecular Therapy. 24:S210
Efforts to expand in vitro the number of engraftable hematopoietic stem cells (HSCs) for transplantation, is an ongoing quest in stem cell biology. Success in this endeavor is critical for increasing insufficient donor cells for transplantation and/o
Autor:
Thalia Papayannopoulou, George Stamatoyannopoulos, Varnavas Constantinou, Evangelia Yannaki, Athanasios Fassas, Achilles Anagnostopoulos, Garyfalia Karponi, Erica C. Jonlin, Ioannis Batsis, Panayotis Kaloyannidis, Angeliki Xagorari, Konstantia Kotta, Asimina Bouinta, Fani Zervou, Pamela S. Becker, Varvara Tahynopoulou, Nikoleta Psatha, Aglaia Athanassiadou
The safety and efficacy of hematopoietic stem cell (HSC) mobilization was investigated in adult splenectomized (SPL) and non-SPL patients with thalassemia major, in two clinical trials, using different mobilization modes: granulocyte-colony-stimulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336a95e4fde6003f13e791b86e48de8c
https://europepmc.org/articles/PMC3255592/
https://europepmc.org/articles/PMC3255592/
Autor:
Nikoleta Psatha, Evangelia Yannaki, Panayotis Baliakas, Thalia Papayannopoulou, George Stamatoyannopoulos, Athanasios Siametis, Achilles Anagnostopoulos, Varnavas Constantinou, Elena K. Siapati, Eleni Sgouramali
Publikováno v:
Blood. 122:4211-4211
A durable therapeutic effect of gene therapy in β-thalassemia largely depends on the infusion of high numbers of genetically-modified hematopoietic stem cells (HSCs) with an enhanced engrafting potential.These requirements are necessary to compensat