Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nikoleta Pavelkova"'
Publikováno v:
Physiology. 38
Airway hyperreactivity (AHR) is a hallmark of allergic asthma, and the major cause of exacerbations. Although acute bronchospasm can be mitigated by bronchodilators and corticosteroids, no therapeutics effectively target AHR. Recent studies have show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d031daf730d8b8dfc44755b0aecb663
https://doi.org/10.1152/physiol.2023.38.s1.5734190
https://doi.org/10.1152/physiol.2023.38.s1.5734190
Publikováno v:
British Journal of Pharmacology. 179:242-251
BACKGROUND AND PURPOSE The purpose of this study was to determine the role of NaV 1.7 in action potential conduction in C-fibres in the bronchial branches of the human vagus nerve. EXPERIMENTAL APPROACH Bronchial branches of the vagus nerve were diss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f5209282165c9b8c285b527408767aa
https://doi.org/10.1111/bph.15686
https://doi.org/10.1111/bph.15686
Autor:
Mayur J. Patil, Marian Kollarik, Nikoleta Pavelkova, Stephen H. Hadley, Thomas E. Taylor-Clark
Publikováno v:
Am J Physiol Regul Integr Comp Physiol
Action potentials depend on voltage-gated sodium channels (NaV1s), which have nine α subtypes. NaV1 inhibition is a target for pathologies involving excitable cells such as pain. However, because NaV1 subtypes are widely expressed, inhibitors may in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04179a38d62975f2a42a9af421469be9
https://doi.org/10.1152/ajpregu.00199.2021
https://doi.org/10.1152/ajpregu.00199.2021
Autor:
Nikoleta Pavelkova, Fei Ru, Marian Kollarik, Jeff S. McDermott, Bradley J. Undem, Jeffrey L. Krajewski
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 319:G443-G453
We investigated voltage-gated sodium channel (NaV1) subunits that regulate action potential initiation in the nerve terminals of vagal nodose C-fibers innervating the esophagus. Extracellular single fiber recordings were made from the nodose C-fibers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b51edd8ee1cb45b6c87c6855b878167
https://doi.org/10.1152/ajpgi.00122.2019
https://doi.org/10.1152/ajpgi.00122.2019
Autor:
Marian, Kollarik, Fei, Ru, Nikoleta, Pavelkova, John, Mulcahy, John, Hunter, Bradley J, Undem
Publikováno v:
British journal of pharmacologyREFERENCES. 179(2)
The purpose of this study was to determine the role of NaBronchial branches of the vagus nerve were dissected from human donor tissue. The C-wave of the electrically evoked compound action potential was quantified in the absence and presence of incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cbc6b4b1145c02ccb4600b340f1a9a0a
https://pubmed.ncbi.nlm.nih.gov/34634134
https://pubmed.ncbi.nlm.nih.gov/34634134
Publikováno v:
Gastroenterologie a hepatologie. 73:313-318
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d09a6969504791625c1e9627256b7b1
https://doi.org/10.14735/amgh2019313
https://doi.org/10.14735/amgh2019313
Autor:
Li, Yu, Kojun, Tsuji, Izumi, Ujihara, Qi, Liu, Nikoleta, Pavelkova, Takanori, Tsujimura, Makoto, Inoue, Sonya, Meeker, Eric, Nisenbaum, Jeff S, McDermott, Jeff, Krajewski, Bradley J, Undem, Marian, Kollarik, Brendan J, Canning
Publikováno v:
European journal of pharmacology. 907
Our previous studies implicated the voltage-gated sodium channel subtype Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4c7f7b2eaec0738933befe0e9f1da987
https://pubmed.ncbi.nlm.nih.gov/34010618
https://pubmed.ncbi.nlm.nih.gov/34010618
Autor:
Fei, Ru, Nikoleta, Pavelkova, Jeffrey L, Krajewski, Jeff S, McDermott, Bradley J, Undem, Marian, Kollarik
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
We investigated voltage-gated sodium channel (Na(V)1) subunits that regulate action potential initiation in the nerve terminals of vagal nodose C-fibers innervating the esophagus. Extracellular single fiber recordings were made from the nodose C-fibe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b4eb6fcaf532477a201b9c5c0d2a55e8
https://pubmed.ncbi.nlm.nih.gov/32726130
https://pubmed.ncbi.nlm.nih.gov/32726130
Autor:
Kojun Tsuji, Marian Kollarik, Qi Liu, Makoto Inoue, Jeff S. McDermott, Nikoleta Pavelkova, Takanori Tsujimura, Bradley J. Undem, Jeff Krajewski, Li Yu, Eric S. Nisenbaum, Brendan J. Canning, Sonya Meeker, Izumi Ujihara
Publikováno v:
European Journal of Pharmacology. 907:174192
Our previous studies implicated the voltage-gated sodium channel subtype NaV 1.7 in the transmission of action potentials by the vagal afferent nerves regulating cough and thus identified this channel as a rational therapeutic target for antitussive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83f3b8670a3b717e295852cbb275c051
https://doi.org/10.1016/j.ejphar.2021.174192
https://doi.org/10.1016/j.ejphar.2021.174192
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8d0c4989e4f16d6361cd43742195db5
https://doi.org/10.1096/fasebj.2019.33.1_supplement.763.4
https://doi.org/10.1096/fasebj.2019.33.1_supplement.763.4