Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Nikolay V. Plotnikov"'
Autor:
Jung-Hoon Lee, Maren Thomsen, Herwin Daub, Stefan C. Steinbacher, Agnieszka Sztyler, Gabriel Thieulin-Pardo, Tobias Neudegger, Nikolay V. Plotnikov, Ravi R. Iyer, Hilary A. Wilkinson, Edith Monteagudo, Dan P. Felsenfeld, Tasir S. Haque, Michael Finley, Celia Dominguez, Thomas F. Vogt, Brinda C. Prasad
Huntington’s disease (HD) is fatal neurodegenerative disorder caused by the expansion of a CAG-repeat tract in the huntingtin (HTT) gene. Human and mouse genetics studies have demonstrated a role for DNA mismatch repair (MMR) proteins which control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::183b5ff9f85869d81d144088519fcbbf
https://doi.org/10.1101/2023.05.08.539930
https://doi.org/10.1101/2023.05.08.539930
Publikováno v:
Journal of Pharmacy and Pharmacology. 70:595-608
Objectives The purpose of this article is to introduce an emerging field called ‘Biopharmaceutical Informatics’. It describes how tools from Information technology and Molecular Biophysics can be adapted, developed and gainfully employed in disco
Publikováno v:
The Journal of Physical Chemistry B. 121:719-730
Early identification of asparagine deamidation and aspartate isomerization degradation sites can facilitate the successful development of biopharmaceuticals. Several knowledge-based models have been proposed to assess these degradation risks. In this
Autor:
Dana D. Dlott, Semin Lee, Yi Ren, Mark Burgess, James M. Christensen, Jeffrey S. Moore, Todd J. Martínez, Nikolay V. Plotnikov
Publikováno v:
Chemistry of Materials. 28:6446-6449
Autor:
Todd J. Martínez, Nikolay V. Plotnikov
Publikováno v:
The Journal of Physical Chemistry C. 120:17898-17908
The observed pressure sensitivity of the isomerization reaction rate of bis-anthracene cyclophane photoisomer has attracted significant attention in the rational design of mechanically sensitive materials. However, the molecular origin of this sensit
Autor:
Elizabeth J. Rivera, Brian Donovan, Ami S. Lakdawala, Nikolay V. Plotnikov, Xiaoyang Dong, Barry S. Brown, Robert Singhaus, Khuram W. Chaudhary, Rachel D. Totoritis, Adam Kenneth Charnley, Michael Reilly, Terry Vincent Hughes, Joseph J. Romano, Pamela A. Haile, Robert W. Marquis, Michael Jonathan Bury, John F. Mehlmann, Gren Z. Wang, Rakesh Nagilla, Bartholomew J. Votta, Barbara A. Swift, Linda N. Casillas, Demartino Michael P, Peter J. Gough, Mukesh K. Mahajan, Carol A. Capriotti, Biva M. Desai, Scott B. Berger, Carol LePage, Helen H. Sun, David B. Lipshutz, John Bertin, Máire A. Convery, Chaya Duraiswami, Michael T. Ouellette
Publikováno v:
ACS Medicinal Chemistry Letters. 11:1353-1353
Autor:
Rachel D. Totoritis, Robert Singhaus, Brian Donovan, Nikolay V. Plotnikov, John F. Mehlmann, Terry Vincent Hughes, Michael Jonathan Bury, Pamela A. Haile, Khuram W. Chaudhary, Gren Z. Wang, Peter J. Gough, Biva M. Desai, Michael T. Ouellette, Michael Reilly, Mukesh K. Mahajan, Barry S. Brown, Scott B. Berger, Xiaoyang Dong, Carol A. Capriotti, Carol LePage, Bartholomew J. Votta, Helen H. Sun, David B. Lipshutz, John Bertin, Joseph J. Romano, Adam Kenneth Charnley, Ami S. Lakdawala, Robert W. Marquis, Barbara A. Swift, Rakesh Nagilla, Máire A. Convery, Demartino Michael P, Elizabeth J. Rivera, Linda N. Casillas
Publikováno v:
ACS Med Chem Lett
[Image: see text] RIP2 kinase was recently identified as a therapeutic target for a variety of autoimmune diseases. We have reported previously a selective 4-aminoquinoline-based RIP2 inhibitor GSK583 and demonstrated its effectiveness in blocking do
Autor:
Nikolay V. Plotnikov
Publikováno v:
Theory and Applications of the Empirical Valence Bond Approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c65b2bf2b2a15a45257512e62e29584e
https://doi.org/10.1002/9781119245544.ch3
https://doi.org/10.1002/9781119245544.ch3
Autor:
Nikolay V. Plotnikov
Publikováno v:
Journal of Chemical Theory and Computation
Proposed in this contribution is a protocol for calculating fine-physics (e.g., ab initio QM/MM) free-energy surfaces at a high level of accuracy locally (e.g., only at reactants and at the transition state for computing the activation barrier) from
Publikováno v:
Proceedings of the National Academy of Sciences. 110:20509-20514
GTPases play a major role in cellular processes, and gaining quantitative understanding of their activation demands reliable free energy surfaces of the relevant mechanistic paths in solution, as well as the interpolation of this information to GTPas