Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Nikolay Popgeorgiev"'
Autor:
Rudy Gadet, Lea Jabbour, Trang Thi Minh Nguyen, Olivier Lohez, Ivan Mikaelian, Philippe Gonzalo, Tomas Luyten, Mounira Chalabi-Dchar, Anne Wierinckx, Olivier Marcillat, Geert Bultynck, Ruth Rimokh, Nikolay Popgeorgiev, Germain Gillet
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Apoptosis plays a role in cell homeostasis in both normal development and disease. Bcl-xL, a member of the Bcl-2 family of proteins, regulates the intrinsic mitochondrial pathway of apoptosis. It is overexpressed in several cancers. Bcl-xL h
Externí odkaz:
https://doaj.org/article/34c348a12fb44ef2916bea077f155ce7
Autor:
Minh Quang Duong, Rudy Gadet, Isabelle Treilleux, Stéphane Borel, Adrien Nougarède, Olivier Marcillat, Philippe Gonzalo, Ivan Mikaelian, Nikolay Popgeorgiev, Ruth Rimokh, Germain Gillet
Publikováno v:
Cell Death and Disease, Vol 14, Iss 6, Pp 1-9 (2023)
Abstract Overexpression of Bcl-2 proteins such as Bcl2L10, also referred to as Nrh, is associated with resistance to therapy and poor survival in various cancers, including breast cancer, lung cancer, and leukemia. The single nucleotide polymorphism
Externí odkaz:
https://doaj.org/article/21892e6332784a7cbd99c5b6c69b9cc3
Autor:
Nikolay Popgeorgiev, Mart Krupovic, Julien Hiblot, Laura Fancello, Sonia Monteil-Bouchard, Christelle Desnues
Publikováno v:
Viruses, Vol 16, Iss 3, p 475 (2024)
Viruses infecting bacteria (bacteriophages) represent the most abundant viral particles in the human body. They participate in the control of the human-associated bacterial communities and play an important role in the dissemination of virulence gene
Externí odkaz:
https://doaj.org/article/f7c75a6a7f354c37845501e6d85eb513
Autor:
Trang Thi Minh Nguyen, Rudy Gadet, Marine Lanfranchi, Romane A. Lahaye, Sozerko Yandiev, Olivier Lohez, Ivan Mikaelian, Lea Jabbour, Ruth Rimokh, Julien Courchet, Frédéric Saudou, Nikolay Popgeorgiev, Germain Gillet
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106674- (2023)
Summary: Non-lethal caspase activation (NLCA) has been linked to neurodevelopmental processes. However, how neurons control NLCA remains elusive. Here, we focused on Bcl-xL, a Bcl-2 homolog regulating caspase activation through the mitochondria. We g
Externí odkaz:
https://doaj.org/article/718d9620594a4db9b98ffb08eb9f6acb
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The caspase family of cysteine proteases represents the executioners of programmed cell death (PCD) type I or apoptosis. For years, caspases have been known for their critical roles in shaping embryonic structures, including the development of the ce
Externí odkaz:
https://doaj.org/article/52ad20d2ecbc418bacd8e729f5a2be15
Autor:
Gabriel Ichim, Benjamin Gibert, Sahil Adriouch, Catherine Brenner, Nathalie Davoust, Solange Desagher, David Devos, Svetlana Dokudovskaya, Laurence Dubrez, Jérôme Estaquier, Germain Gillet, Isabelle Guénal, Philippe P. Juin, Guido Kroemer, Patrick Legembre, Romain Levayer, Stéphen Manon, Patrick Mehlen, Olivier Meurette, Olivier Micheau, Bernard Mignotte, Florence Nguyen-Khac, Nikolay Popgeorgiev, Jean-Luc Poyet, Muriel Priault, Jean-Ehrland Ricci, Franck B. Riquet, Santos A. Susin, Magali Suzanne, Pierre Vacher, Ludivine Walter, Bertrand Mollereau
Publikováno v:
Biomolecules, Vol 12, Iss 7, p 901 (2022)
Since the Nobel Prize award more than twenty years ago for discovering the core apoptotic pathway in C. elegans, apoptosis and various other forms of regulated cell death have been thoroughly characterized by researchers around the world. Although ma
Externí odkaz:
https://doaj.org/article/a7116fd2eb2845b5911a169d405c21e9
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3730 (2021)
Bcl-2 family proteins are considered as one of the major regulators of apoptosis. Indeed, this family is known to control the mitochondrial outer membrane permeabilization (MOMP): a central step in the mitochondrial pathway of apoptosis. However, in
Externí odkaz:
https://doaj.org/article/1492a68db57b487c9a5bb4b1ad03936e
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
Bcl-2 family proteins are recognized as major regulators of the mitochondrial pathway of apoptosis. They control the mitochondrial outer membrane permeabilization (MOMP) by directly localizing to this organelle. Further investigations demonstrated th
Externí odkaz:
https://doaj.org/article/7f31730b1b3c4a2c80fb634d3f153455
Autor:
Laura Fancello, Sonia Monteil, Nikolay Popgeorgiev, Romain Rivet, Frédérique Gouriet, Pierre-Edouard Fournier, Didier Raoult, Christelle Desnues
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93367 (2014)
Pericarditis is a common human disease defined by inflammation of the pericardium. Currently, 40% to 85% of pericarditis cases have no identified etiology. Most of these cases are thought to be caused by an infection of undetected, unsuspected or unk
Externí odkaz:
https://doaj.org/article/904a61cfe4e4475ab9fcd0aedabca20e
Autor:
Annabelle Ballesta, Jonathan Lopez, Nikolay Popgeorgiev, Philippe Gonzalo, Marie Doumic, Germain Gillet
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 4, p e1003011 (2013)
Src tyrosine kinases are deregulated in numerous cancers and may favor tumorigenesis and tumor progression. We previously described that Src activation in NIH-3T3 mouse fibroblasts promoted cell resistance to apoptosis. Indeed, Src was found to accel
Externí odkaz:
https://doaj.org/article/5cd44397c7bb4d5887126599599dbc72