Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Nikolay N, Sokolov"'
Autor:
Anna A. Plyasova, Marina V. Pokrovskaya, Olga M. Lisitsyna, Vadim S. Pokrovsky, Svetlana S. Alexandrova, Abdullah Hilal, Nikolay N. Sokolov, Dmitry D. Zhdanov
Publikováno v:
Pharmaceuticals, Vol 17, Iss 6, p 684 (2024)
In the original publication [...]
Externí odkaz:
https://doaj.org/article/cde648aef38e4a38bfaff6518d55e938
Autor:
Natalia V. Dobryakova, Dmitry D. Zhdanov, Nikolay N. Sokolov, Svetlana S. Aleksandrova, Marina V. Pokrovskaya, Elena V. Kudryashova
Publikováno v:
Applied Sciences, Vol 13, Iss 5, p 3373 (2023)
L-asparaginase Rhodospirillum rubrum (RrA) is an enzyme (amidohydrolases; EC 3.5.1.1) that catalyzes the L-asparagine hydrolysis reaction to form L-aspartic acid. Due to the shortcomings of existing L-asparaginases from Esherichia coli (EcA) and Erwi
Externí odkaz:
https://doaj.org/article/a2972d5afe564446a78c39aef6426168
Autor:
Natalia V. Dobryakova, Dmitry D. Zhdanov, Nikolay N. Sokolov, Svetlana S. Aleksandrova, Marina V. Pokrovskaya, Elena V. Kudryashova
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 406 (2022)
L-asparaginases (L-ASNases, EC 3.5.1.1) are a family of enzymes that are widely used for the treatment of lymphoblastic leukemias. L-ASNase from Rhodospirillum rubrum (RrA) has a low molecular weight, low glutaminase activity, and low immunogenicity,
Externí odkaz:
https://doaj.org/article/0c06139e142744e68451b684a8a3e0ff
Autor:
Marina V. Pokrovskaya, Vadim S. Pokrovsky, Svetlana S. Aleksandrova, Nikolay N. Sokolov, Dmitry D. Zhdanov
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 599 (2022)
L-asparaginases (EC 3.5.1.1) are a family of enzymes that catalyze the hydrolysis of L-asparagine to L-aspartic acid and ammonia. These proteins with different biochemical, physicochemical and pharmacological properties are found in many organisms, i
Externí odkaz:
https://doaj.org/article/564d670433004c62ac6e6cec22521742
Autor:
Anna A. Plyasova, Marina V. Pokrovskaya, Olga M. Lisitsyna, Vadim S. Pokrovsky, Svetlana S. Alexandrova, Abdullah Hilal, Nikolay N. Sokolov, Dmitry D. Zhdanov
Publikováno v:
Pharmaceuticals, Vol 13, Iss 10, p 286 (2020)
The anticancer effect of L-asparaginases (L-ASNases) is attributable to their ability to hydrolyze L-asparagine in the bloodstream and cancer cell microenvironment. Rhodospirillum rubrum (RrA) has dual mechanism of action and plays a role in the supp
Externí odkaz:
https://doaj.org/article/fa99e70b503349f1b0ce8c3ecc48e67d
Autor:
M. A. Eldarov, M. V. Dumina, A. A. Zhgun, D. D. Zhdanov, M. V. Pokrovskay, Nikolay N. Sokolov, S. S. Aleksandrova
Publikováno v:
Applied Biochemistry and Microbiology. 57:594-602
The activity of novel uncharacterized extremophilic L-asparaginases from the psychrophilic fungi Sclerotinia borealis, the thermoacidophilic crenarchea Acidilobus saccharovorans, and the thermophilic bacteria Melioribacter roseus were studied. Active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d47d034a230eed86105f97716952d98c
https://doi.org/10.1134/s0003683821050057
https://doi.org/10.1134/s0003683821050057
Publikováno v:
Municipal Academy. :86-91
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb02c04600313de073bf048cc7e8b3a5
https://doi.org/10.52176/2304831x_2021_01_86
https://doi.org/10.52176/2304831x_2021_01_86
Publikováno v:
Biomeditsinskaya Khimiya. 66:105-123
L-asparaginase is extensively used in the treatment of acute lymphoblastic leukemia and several other lymphoproliferative diseases. In addition to its biomedical application, L-asparaginase is also of prospective use in food industry to reduce the fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e54226110a008d68495210614910c88
https://doi.org/10.18097/pbmc20206602105
https://doi.org/10.18097/pbmc20206602105
Autor:
A. A. Zhgun, Nikolay N. Sokolov, M. V. Pokrovskaya, Dmitry D. Zhdanov, S. S. Aleksandrova, M. V. Dumina, Michael A. Eldarov
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9894, p 9894 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 18
International Journal of Molecular Sciences
Volume 22
Issue 18
L-asparaginase (L-ASNase) is a vital enzyme with a broad range of applications in medicine and food industry. Drawbacks of current commercial L-ASNases stimulate the search for better-producing sources of the enzyme, and extremophiles are especially
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340bfa6aea6b8cfce720920676165c9c
https://www.mdpi.com/1422-0067/22/18/9894
https://www.mdpi.com/1422-0067/22/18/9894
Autor:
Andrea Angeli, Anna A. Plyasova, Claudiu T. Supuran, Nikolay N. Sokolov, D. D. Zhdanov, M. V. Pokrovskaya, Alexander V. Veselovsky, Marta Ferraroni, Abdullah Hilal, Vadim S. Pokrovsky, Svetlana S. Alexandrova, Fabrizio Carta, Emanuela Berrino, Yulia A. Gladilina, Irina I Khan
Publikováno v:
Journal of medicinal chemistry. 64(15)
Human (h) telomerase (TL; EC 2.7.7.49) plays a key role in sustaining cancer cells by means of elongating telomeric repeats at the 3' ends of chromosomes. Since TL-inhibitor (TI) stand-alone cancer therapy has been proven to be remarkably challenging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b2c35ca71cc4226b0999557f8ed8828
https://pubmed.ncbi.nlm.nih.gov/34283610
https://pubmed.ncbi.nlm.nih.gov/34283610