Zobrazeno 1 - 10
of 609
pro vyhledávání: '"Nikolay A. Zefirov"'
Autor:
Vladimir V. Burmistrov, Christophe Morisseau, Dmitry V. Danilov, Boris P. Gladkikh, Vladimir S. D’yachenko, Nikolay A. Zefirov, Olga N. Zefirova, Gennady M. Butov, Bruce D. Hammock
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Series of 1,3-disubstituted ureas and diadamantyl disubstituted diureas with fluorinated and chlorinated adamantane residues were shown to inhibit human soluble epoxide hydrolase (sEH) with inhibition potency ranging from 40 pM to 9.2 nM. The measure
Externí odkaz:
https://doaj.org/article/a8df2f9e00794074bf2bbc27e9abe427
Autor:
Kseniya N. Sedenkova, Denis N. Leschukov, Yuri K. Grishin, Nikolay A. Zefirov, Yulia A. Gracheva, Dmitry A. Skvortsov, Yanislav S. Hrytseniuk, Lilja A. Vasilyeva, Elena A. Spirkova, Pavel N. Shevtsov, Elena F. Shevtsova, Alina R. Lukmanova, Vasily V. Spiridonov, Alina A. Markova, Minh T. Nguyen, Alexander A. Shtil, Olga N. Zefirova, Alexander A. Yaroslavov, Elena R. Milaeva, Elena B. Averina
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1499 (2023)
Tubulin-targeting agents attract undiminished attention as promising compounds for the design of anti-cancer drugs. Verubulin is a potent tubulin polymerization inhibitor, binding to colchicine-binding sites. In the present work, a series of verubuli
Externí odkaz:
https://doaj.org/article/d15585dc1f164f22bf292e2c887d7428
Autor:
Kseniya N. Sedenkova, Kristian S. Andriasov, Marina G. Eremenko, Yuri K. Grishin, Vera A. Alferova, Anna A. Baranova, Nikolay A. Zefirov, Olga N. Zefirova, Vladimir V. Zarubaev, Yulia A. Gracheva, Elena R. Milaeva, Elena B. Averina
Publikováno v:
Molecules, Vol 27, Iss 11, p 3546 (2022)
The application of non-planar scaffolds in drug design allows for the enlargement of the chemical space, and for the construction of molecules that have more effective target–ligand interactions or are less prone to the development of resistance. A
Externí odkaz:
https://doaj.org/article/9f0af829ca8046d7ba8b5aa268184ca0
Autor:
Evgeniya V. Nurieva, Alexander A. Alexeev, Nikolay A. Zefirov, Elena R. Milaeva, Nadezhda V. Kovaleva, Alexey N. Proshin, Galina F. Makhaeva, Olga N. Zefirova
Publikováno v:
Mendeleev Communications. 33:77-79
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::235d4614aea580b1b8a62de2c712c036
https://doi.org/10.1016/j.mencom.2023.01.024
https://doi.org/10.1016/j.mencom.2023.01.024
Autor:
Nikolay A. Zefirov, Apollonia Glaßl, Evgeniy V. Radchenko, Anastasia N. Borovik, Vladislav V. Stanishevskiy, Elena R. Milaeva, Sergei A. Kuznetsov, Olga N. Zefirova
Publikováno v:
Mendeleev Communications. 32:173-175
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::560193f3341d7f3ecd3e1fe34f53ef2c
https://doi.org/10.1016/j.mencom.2022.03.006
https://doi.org/10.1016/j.mencom.2022.03.006
Autor:
Kirill S. Sadovnikov, Dmitry A. Vasilenko, Yulia A. Gracheva, Nikolay A. Zefirov, Eugene V. Radchenko, Vladimir A. Palyulin, Yuri K. Grishin, Vladislav A. Vasilichin, Alexander A. Shtil, Pavel N. Shevtsov, Elena F. Shevtsova, Tamara S. Kuznetsova, Sergei A. Kuznetsov, Alexander S. Bunev, Olga N. Zefirova, Elena R. Milaeva, Elena B. Averina
Publikováno v:
Archiv der PharmazieREFERENCES. 355(5)
A series of novel antimitotic agents was designed using the replacement of heterocyclic cores in two tubulin-targeting lead molecules with the acylated 4-aminoisoxazole moiety. Target compounds were synthesized via heterocyclization of β-aryl-substi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5264171155ba7af5378cb66c0c7b8fb9
https://pubmed.ncbi.nlm.nih.gov/35103336
https://pubmed.ncbi.nlm.nih.gov/35103336
Autor:
Nikolay S. Zefirov, Elena D. Matveeva
Publikováno v:
ARKIVOC, Vol 2008, Iss 1, Pp 1-17 (2008)
Externí odkaz:
https://doaj.org/article/70630315cda1450480e16de25d1c1492
Autor:
Konstantin V. Kudryavtsev, Anna O. Markevich, Oleksandr V. Virchenko, Tetyana M. Falalyeyeva, Tetyana V. Beregova, Lyudmyla I. Ostapchenko, Dmitry V. Zabolotnev, Nikolay S. Zefirov
Publikováno v:
The Scientific World Journal, Vol 2014 (2014)
This study was designed to determine novel small-molecule agents influencing the pathogenesis of gastric lesions induced by stress. To achieve this goal, four novel organic compounds containing structural fragments with known antioxidant activity wer
Externí odkaz:
https://doaj.org/article/0bb4fccfb4aa4a6f94849aeb97b1dfae
Publikováno v:
Structural Chemistry. 30:509-522
Investigations on the relative energy of two least-strain conformers for bicyclo[3.3.1]nonane 1, bicyclo[3.3.1]nonan-9-one 2, and their heteroanalogues: 3,7-dimethyl-3,7-diazabicyclo[3.3.1]nonane 3, 3,7-dimethyl-3,7-diazabicyclo[3.3.1]nonan-9-one 4 w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5db4f3ced0d417fb06be800f10285df
https://doi.org/10.1007/s11224-018-1240-z
https://doi.org/10.1007/s11224-018-1240-z
Autor:
Anastasia E. Sibiryakova, Eugene V. Radchenko, Dmitry V. Osipov, Anton V. Lukashenko, M. V. Leonova, Larisa N. Shishkina, Yulia A. Gruzd, Vera A. Shadrikova, M. R. Baimuratov, Vadim A. Shiryaev, Ilya M. Tkachenko, O. A. Serova, E. A. Ivleva, Vladimir A. Palyulin, Alexander N. Reznikov, V. A. Osyanin, Kseniya M. Bormasheva, N. I. Bormotov, Yuri N. Klimochkin, Nikolay S. Zefirov
Publikováno v:
European Journal of Medicinal Chemistry. 158:214-235
The hepatitis C caused by the hepatitis C virus (HCV) is an acute and/or chronic liver disease ranging in severity from a mild brief ailment to a serious lifelong illness that affects up to 3% of the world population and imposes significant and incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e2c1e7176c5d4725dc30b63d7481a7
https://doi.org/10.1016/j.ejmech.2018.08.009
https://doi.org/10.1016/j.ejmech.2018.08.009