Zobrazeno 1 - 10
of 431
pro vyhledávání: '"Nikolay V. Dokholyan"'
Autor:
Hemerson Casado Gama, Mariana A. Amorós, Mykaella Andrade de Araújo, Congzhou M. Sha, Mirella P.S. Vieira, Rayssa G.D. Torres, Gabriela F. Souza, Janaína A. Junkes, Nikolay V. Dokholyan, Daniel Leite Góes Gitaí, Marcelo Duzzioni
Publikováno v:
Non-coding RNA Research, Vol 9, Iss 2, Pp 523-535 (2024)
The discovery of disease-specific biomarkers, such as microRNAs (miRNAs), holds the potential to transform the landscape of Amyotrophic Lateral Sclerosis (ALS) by facilitating timely diagnosis, monitoring treatment response, and accelerating drug dis
Externí odkaz:
https://doaj.org/article/484ccf4e00ca48b0b33845585584869b
Publikováno v:
Frontiers in Computational Neuroscience, Vol 18 (2024)
The question of how consciousness and behavior arise from neural activity is fundamental to understanding the brain, and to improving the diagnosis and treatment of neurological and psychiatric disorders. There is significant murine and primate liter
Externí odkaz:
https://doaj.org/article/83905e54997d49a1b9be8ddfcc867164
Autor:
Venkat R. Chirasani, Mohammad Ashhar I. Khan, Juilee N. Malavade, Nikolay V. Dokholyan, Brenton D. Hoffman, Sharon L. Campbell
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract The ability of cells and tissues to respond differentially to mechanical forces applied in distinct directions is mediated by the ability of load-bearing proteins to preferentially maintain physical linkages in certain directions. However, t
Externí odkaz:
https://doaj.org/article/077472f443c64a9687cc9e7896f64cc6
Publikováno v:
eLife, Vol 12 (2023)
The dysregulation of protein kinases is associated with multiple diseases due to the kinases' involvement in a variety of cell signaling pathways. Manipulating protein kinase function, by controlling the active site, is a promising therapeutic and in
Externí odkaz:
https://doaj.org/article/bfad949894844eb68f9ea58fc6aa2484
Autor:
Mohammad Mahmoudi Gomari, Shadi Abkhiz, Taha Ghantab Pour, Ehsan Lotfi, Neda Rostami, Fatemeh Nafe Monfared, Babak Ghobari, Mona Mosavi, Behruz Alipour, Nikolay V. Dokholyan
Publikováno v:
Molecular Medicine, Vol 28, Iss 1, Pp 1-17 (2022)
Abstract The low efficiency of treatment strategies is one of the main obstacles to developing cancer inhibitors. Up to now, various classes of therapeutics have been developed to inhibit cancer progression. Peptides due to their small size and easy
Externí odkaz:
https://doaj.org/article/91091b7f625744d9a2db0c6901ed8f33
Autor:
Wesley M. Raup-Konsavage, Diana E. Sepulveda, Jian Wang, Nikolay V. Dokholyan, Kent E. Vrana, Nicholas M. Graziane
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 83 (2023)
Cannabis sativa contains minor cannabinoids that have potential therapeutic value in pain management. However, detailed experimental evidence for the antinociceptive effects of many of these minor cannabinoids remains lacking. Here, we employed artif
Externí odkaz:
https://doaj.org/article/ba288f61559e47d9a875935905b39aa4
Autor:
Balaji Chandrasekaran, Ashish Tyagi, Uttara Saran, Venkatesh Kolluru, Becca V. Baby, Venkat R. Chirasani, Nikolay V. Dokholyan, Jyh M. Lin, Amandeep Singh, Arun K. Sharma, Murali K. Ankem, Chendil Damodaran
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
We investigated the efficacy of a small molecule ASR-600, an analog of Urolithin A (Uro A), on blocking androgen receptor (AR) and its splice variant AR-variant 7 (AR-V7) signaling in castration-resistant prostate cancer (CRPC). ASR-600 effectively s
Externí odkaz:
https://doaj.org/article/3c39b919e8a144f49978bb9232157b3f
Autor:
Xinying Fang, Xinyi Liu, Vernon M. Chinchilli, Michael Wang, Hong-Gang Wang, Nikolay V. Dokholyan, Chan Shen, J. Jack Lee, Shouhao Zhou
Publikováno v:
Journal of Clinical and Translational Science, Vol 7 (2023)
REAP-2 is an interactive dose-response curve estimation tool for Robust and Efficient Assessment of drug Potency. It provides user-friendly dose-response curve estimation for in vitro studies and conducts statistical testing for model comparisons wit
Externí odkaz:
https://doaj.org/article/8e75aa5f598d4374a323926ecc254c7e
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immunotherapy has emerged as a breakthrough strategy in cancer treatment. mRNA vaccines are an attractive and powerful immunotherapeutic platform against cancer because of their high potency, specificity, versatility, rapid and large-scale developmen
Externí odkaz:
https://doaj.org/article/3e9932e0f7b64238a6439efa4121c9c5
Autor:
Yashavantha L. Vishweshwaraiah, Jiaxing Chen, Venkat R. Chirasani, Erdem D. Tabdanov, Nikolay V. Dokholyan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Traditional synthetic biology tools operate by complex re-programming of DNA, requiring significant amount of ‘nucleotide-based code’ to implement instructions that are transcribed at the protein level. Here the authors demonstrate the direct reg
Externí odkaz:
https://doaj.org/article/ab071c86d66445339a7e6c2b7d6132f6