Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Nikolaus Jork"'
Autor:
Shreya Ghosh, Ana M. Sanchez, Beate Schwer, Isabel Prucker, Nikolaus Jork, Henning J. Jessen, Stewart Shuman
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT Inositol pyrophosphate 1,5-IP8 regulates expression of a fission yeast phosphate homeostasis regulon, comprising phosphate acquisition genes pho1, pho84, and tgp1, via its action as an agonist of precocious termination of transcription of th
Externí odkaz:
https://doaj.org/article/5f61dc258abb4be5a6c4a2a0fa42b05e
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Inositol pyrophosphate 1,5-IP8 is a signaling molecule that regulates phosphate and polyphosphate homeostasis in the fission yeast Schizosaccharomyces pombe. 1,5-IP8 levels are dictated by a balance between the Asp1 kinase domain that conver
Externí odkaz:
https://doaj.org/article/f23c6334623f4c619e81c4cb2fd23874
Autor:
Huanchen Wang, Lalith Perera, Nikolaus Jork, Guangning Zong, Andrew M. Riley, Barry V. L. Potter, Henning J. Jessen, Stephen B. Shears
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Inositol pyrophosphates (PP-IPs) regulate immunity and phosphate homeostasis. Here, the authors’ structural dissection of an Arabidopsis thaliana PP-IP phosphatase reveals that substrates drive their own hydrolysis and identifies a highly elusive m
Externí odkaz:
https://doaj.org/article/80727188fe0e4b42b9d3d714ec578029
Autor:
Bradley Benjamin, Yehuda Goldgur, Nikolaus Jork, Henning J. Jessen, Beate Schwer, Stewart Shuman
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Expression of the fission yeast Schizosaccharomyces pombe phosphate regulon is sensitive to the intracellular level of the inositol pyrophosphate signaling molecule 1,5-IP8. IP8 dynamics are determined by Asp1, a bifunctional enzyme consisti
Externí odkaz:
https://doaj.org/article/05a2bc5f0397413b89f734e199a4c266
Publikováno v:
Biomolecules, Vol 13, Iss 7, p 1150 (2023)
Inositol phosphates constitute a family of highly charged messenger molecules that play diverse roles in cellular processes. The various phosphorylation patterns they exhibit give rise to a vast array of different compounds. To fully comprehend the b
Externí odkaz:
https://doaj.org/article/f9f021d79b9c4545b012152d578fea81
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Inositol pyrophosphates (IPPs) are signaling molecules that regulate cellular phosphate homeostasis in diverse eukaryal taxa. In fission yeast, mutations that increase 1,5-IP8 derepress the PHO regulon while mutations that ablate IP8 synthes
Externí odkaz:
https://doaj.org/article/6ba196c8fe054fb58576215ba25bc178
Autor:
Danye Qiu, Miranda S. Wilson, Verena B. Eisenbeis, Robert K. Harmel, Esther Riemer, Thomas M. Haas, Christopher Wittwer, Nikolaus Jork, Chunfang Gu, Stephen B. Shears, Gabriel Schaaf, Bernd Kammerer, Dorothea Fiedler, Adolfo Saiardi, Henning J. Jessen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Myo-Inositol phosphates (InsPs) and pyrophosphates (PP-InsPs) are important second messengers but their analysis remains challenging. Here, the authors develop a capillary electrophoresis-mass spectrometry method for the identification and quantitati
Externí odkaz:
https://doaj.org/article/a6c9f68025794db3aaf128b31c15130b
Autor:
Hasti Mohsenin, Jennifer Pacheco, Svenja Kemmer, Hanna J. Wagner, Nico Höfflin, Toquinha Bergmann, Tim Baumann, Alexander Ripp, Nikolaus Jork, Henning J. Jessen, Maja Köhn, Jens Timmer, Wilfried Weber
Protein tags play an important role in various chemical biological applications and synthetic biological systems. An ideal protein tag enables labelling of proteins, their monitoring, and detection. Moreover, it forms a stable bond with its specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c0724ef939bd9b3fbf5df7b9c4712b0
https://doi.org/10.1101/2023.05.18.541264
https://doi.org/10.1101/2023.05.18.541264
Autor:
Philipp Gaugler, Robin Schneider, Guizhen Liu, Danye Qiu, Jonathan Weber, Jochen Schmid, Nikolaus Jork, Markus Häner, Kevin Ritter, Nicolás Fernández-Rebollo, Ricardo F.H. Giehl, Minh Nguyen Trung, Ranjana Yadav, Dorothea Fiedler, Verena Gaugler, Henning J. Jessen, Gabriel Schaaf, Debabrata Laha
Inositol pyrophosphates are signaling molecules containing at least one phosphoanhydride bond that regulate a wide range of cellular processes in eukaryotes. With a cyclic array of phosphate esters and diphosphate groups around myo-inositol, these mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::823f89bb4b11b4aee7a316fd1d4e15af
https://doi.org/10.1101/2022.03.01.482514
https://doi.org/10.1101/2022.03.01.482514
Autor:
Soumyadip Sahu, Dorothea Fiedler, Stephen B. Shears, Chunfang Gu, Nikolaus Jork, Megerditch Kiledjian, Sarah Hostachy, Christopher Wittwer, Henning J. Jessen, Xingyao Li, Huanchen Wang, Zhenzhen Wang, Xinfu Jiao
Publikováno v:
Proceedings of the National Academy of Sciences. 117:19245-19253
Regulation of enzymatic 5' decapping of messenger RNA (mRNA), which normally commits transcripts to their destruction, has the capacity to dynamically reshape the transcriptome. For example, protection from 5' decapping promotes accumulation of mRNAs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecac6325086313d5f731764ae2277792
https://doi.org/10.1073/pnas.1922284117
https://doi.org/10.1073/pnas.1922284117