P417: GENOMIC LANDSCAPE AND PROGNOSIS IN OLDER ACUTE MYELOID LEUKEMIA PATIENTS NOT ELIGIBLE FOR INTENSIVE CHEMOTHERAPY

Autor: Ekaterina Jahn, Maral Saadati, Pierre Fenaux, Marco Gobbi, Gail Roboz, Lars Bullinger, Pavlo Lutsik, Anna Riedel, Christoph Plass, Nikolaus Jahn, Claudia Walter, Karlheinz Holzmann, Yong Hao, Sue Naim, Nicholas Schreck, Julia Krzykalla, Axel Benner, Harold Keer, Mohammad Azab, Konstanze Döhner, Hartmut Döhner

Publikováno v: HemaSphere, Vol 7, p e09006a7 (2023)

Externí odkaz: https://doaj.org/article/4c2e871905fb42089d1303d5857af0bd

Intermediate monocytes but not TIE2-expressing monocytes are a sensitive diagnostic indicator for colorectal cancer.

Autor: Dominic Schauer, Patrick Starlinger, Christian Reiter, Nikolaus Jahn, Philipp Zajc, Elisabeth Buchberger, Thomas Bachleitner-Hofmann, Michael Bergmann, Anton Stift, Thomas Gruenberger, Christine Brostjan

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e44450 (2012)

We have conducted the first study to determine the diagnostic potential of the CD14++CD16+ intermediate monocytes as compared to the pro-angiogenic subset of CD14++CD16+TIE2+ TIE2-expressing monocytes (TEMs) in cancer. These monocyte populations were

Externí odkaz: https://doaj.org/article/b64abf77200f4592a5a26713925c4fd9

Clonal Hematopoiesis and Its Impact on Human Health

Autor: Herra Ahmad, Nikolaus Jahn, Siddhartha Jaiswal

Publikováno v: Annual review of medicine.

Aging is associated with increased mutational burden in every tissue studied. Occasionally, fitness-increasing mutations will arise, leading to stem cell clonal expansion. This process occurs in several tissues but has been best studied in blood. Clo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71902b8971d0b0a38e124c480465db4e
https://pubmed.ncbi.nlm.nih.gov/36450282

Clonal hematopoiesis is driven by aberrant activation of TCL1A

Autor: Joshua S. Weinstock, Jayakrishnan Gopakumar, Bala Bharathi Burugula, Md Mesbah Uddin, Nikolaus Jahn, Julia A. Belk, Bence Daniel, Nghi Ly, Taralyn M. Mack, Cecelia A. Laurie, Jai G. Broome, Kent D. Taylor, Xiuqing Guo, Moritz F. Sinner, Aenne S. von Falkenhausen, Stefan Kääb, Alan R. Shuldiner, Jeffrey R. O’Connell, Joshua P. Lewis, Eric Boerwinkle, Kathleen C. Barnes, Nathalie Chami, Eimear E. Kenny, Ruth J. Loos, Myriam Fornage, Lifang Hou, Donald M. Lloyd-Jones, Susan Redline, Brian E. Cade, Bruce M. Psaty, Joshua C. Bis, Jennifer A. Brody, Edwin K. Silverman, Jeong H. Yun, Dandi Qiao, Nicholette D. Palmer, Barry I. Freedman, Donald W. Bowden, Michael H. Cho, Dawn L. DeMeo, Ramachandran S. Vasan, Lisa R. Yanek, Lewis C. Becker, Sharon Kardia, Patricia A. Peyser, Jiang He, Michiel Rienstra, Pim Van der Harst, Robert Kaplan, Susan R. Heckbert, Nicholas L. Smith, Kerri L. Wiggins, Donna K. Arnett, Marguerite R. Irvin, Hemant Tiwari, Michael J. Cutler, Stacey Knight, J Brent. Muhlestein, Adolfo Correa, Laura M. Raffield, Yan Gao, Mariza de Andrade, Jerome I. Rotter, Stephen S. Rich, Russell P. Tracy, Barbara A. Konkle, Jill M. Johnsen, Marsha M. Wheeler, J. Gustav Smith, Olle Melander, Peter M. Nilsson, Brian S. Custer, Ravindranath Duggirala, Joanne E. Curran, John Blangero, Stephen McGarvey, L. Keoki Williams, Shujie Xiao, Mao Yang, C. Charles. Gu, Yii-Der Ida. Chen, Wen-Jane Lee, Gregory M. Marcus, John P. Kane, Clive R. Pullinger, M. Benjamin Shoemaker, Dawood Darbar, Dan Roden, Christine Albert, Charles Kooperberg, Ying Zhou, JoAnn E. Manson, Pinkal Desai, Andrew Johnson, Rasika Mathias, Thomas W. Blackwell, Goncalo R. Abecasis, Albert V. Smith, Hyun M. Kang, Ansuman T. Satpathy, Pradeep Natarajan, Jacob Kitzman, Eric Whitsel, Alexander P. Reiner, Alexander G. Bick, Sidd Jaiswal

A diverse set of driver genes, such as regulators of DNA methylation, RNA splicing, and chromatin remodeling, have been associated with pre-malignant clonal expansion of hematopoietic stem cells (HSCs). The factors mediating expansion of these mutant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c2602e34829067c8289a05cb0696895
https://doi.org/10.1101/2021.12.10.471810

Efficacy and the Adverse Effects of Oral Versus Intravenous Arsenic for Acute Promyelocytic Leukemia: A Meta-Analysis of Randomized-Controlled Studies

Autor: Weerapat Owattanapanich, Natthaporn Sasijareonrat, Nikolaus Jahn, Patompong Ungprasert

Publikováno v: Technology in Cancer Research & Treatment
Technology in Cancer Research & Treatment, Vol 19 (2020)

Acute promyelocytic leukemia, a subtype of acute myeloid leukemia, is highly curable. In subgroup of patients with non-high-risk acute promyelocytic leukemia, intravenous arsenic trioxide plus all-trans-retinoic acid is considered the preferred regim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc04b6218a476c5fdbcb1df08831483f
https://pubmed.ncbi.nlm.nih.gov/32583728