Zobrazeno 1 - 10
of 306
pro vyhledávání: '"Nikolaus Gassler"'
Autor:
Paola Berenice Mass-Sanchez, Marinela Krizanac, Paula Štancl, Marvin Leopold, Kathrin M. Engel, Eva Miriam Buhl, Josef van Helden, Nikolaus Gassler, Jürgen Schiller, Rosa Karlić, Diana Möckel, Twan Lammers, Steffen K. Meurer, Ralf Weiskirchen, Anastasia Asimakopoulos
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract The molecular mechanisms underlying the transition from nonalcoholic fatty liver disease (NAFLD) to hepatocellular carcinoma (HCC) are incompletely understood. During the development of NAFLD, Perilipin 5 (PLIN5) can regulate lipid metabolis
Externí odkaz:
https://doaj.org/article/2fdd9001212f423bba51c0fecc09dd17
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8352 (2024)
Adipose tissue dysfunction, which is associated with an increased risk of colorectal cancer (CRC), is a significant factor in the pathophysiology of obesity. Obesity-related inflammation and extracellular matrix (ECM) remodeling promote colorectal ca
Externí odkaz:
https://doaj.org/article/b78c2aa162a64f46affc74d9f3e77abb
Autor:
Wenfang Gui, Mikal Jacob Hole, Antonio Molinaro, Karolina Edlund, Kristin K. Jørgensen, Huan Su, Brigitte Begher-Tibbe, Nikolaus Gaßler, Carolin V. Schneider, Uthayakumar Muthukumarasamy, Antje Mohs, Lijun Liao, Julius Jaeger, Christian J. Mertens, Ina Bergheim, Till Strowig, Jan G. Hengstler, Johannes R. Hov, Hanns-Ulrich Marschall, Christian Trautwein, Kai Markus Schneider
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by chronic inflammation and progressive fibrosis of the biliary tree. The majority of PSC patients suffer from concomitant inflammatory bowel disease (
Externí odkaz:
https://doaj.org/article/822db6e3defc4196a740ad1cdce3eff7
Autor:
Jessica Hoff, Ling Xiong, Tobias Kammann, Sophie Neugebauer, Julia M. Micheel, Nikolaus Gaßler, Michael Bauer, Adrian T. Press
Publikováno v:
Cell Death and Disease, Vol 14, Iss 4, Pp 1-16 (2023)
Abstract Necroptosis facilitates cell death in a controlled manner and is employed by many cell types following injury. It plays a significant role in various liver diseases, albeit the cell-type-specific regulation of necroptosis in the liver and es
Externí odkaz:
https://doaj.org/article/fafdec10994e41eb93f99e613ef4c196
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4805 (2024)
The gradual loss of kidney function due to increasing age is accompanied by structural changes such as fibrosis of the tissue. The underlying molecular mechanisms are complex, but not yet fully understood. Non-fibrillar collagen type VIII (COL8) coul
Externí odkaz:
https://doaj.org/article/8ae126bb66bf4ce9801efdbf83a7a74a
Autor:
Yunxia Ma, Miljana Nenkov, Alexander Berndt, Mohamed Abubrig, Martin Schmidt, Tim Sandhaus, Otmar Huber, Joachim H. Clement, Susanne M. Lang, Yuan Chen, Nikolaus Gaßler
Publikováno v:
Cancers, Vol 16, Iss 6, p 1170 (2024)
Abnormal expression of ACSL members 1, 3, 4, 5, and 6 is frequently seen in human cancer; however, their clinical relevance is unclear. In this study, we analyzed the expression of ACSLs and investigated the effects of the ACSL inhibitor Triacsin C (
Externí odkaz:
https://doaj.org/article/96cb0d2246844d33bec23bee2a6fdc35
Autor:
Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Peixin Dong, Nikolaus Gassler, Mohammad Taheri, Aria Baniahmad, Nader Akbari Dilmaghani
Publikováno v:
Cancer Cell International, Vol 22, Iss 1, Pp 1-69 (2022)
Abstract The Cyclin-dependent kinase (CDK) class of serine/threonine kinases has crucial roles in the regulation of cell cycle transition and is mainly involved in the pathogenesis of cancers. The expression of CDKs is controlled by a complex regulat
Externí odkaz:
https://doaj.org/article/0a0c9af078f04b028b0f715b2d066b3a
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 6 (2023)
The farnesoid-X receptor (FXR), a member of the nuclear hormone receptor superfamily, can be activated by bile acids (BAs). BAs binding to FXR activates BA signaling which is important for maintaining BA homeostasis. FXR is differentially expressed i
Externí odkaz:
https://doaj.org/article/e36ac14809e943a6b5f4ad3ac969d66b
Autor:
Dustin Beyer, Jessica Hoff, Oliver Sommerfeld, Alexander Zipprich, Nikolaus Gaßler, Adrian T. Press
Publikováno v:
Molecular Medicine, Vol 28, Iss 1, Pp 1-15 (2022)
Abstract Liver failure is a life-threatening complication of infections restricting the host's response to infection. The pivotal role of the liver in metabolic, synthetic, and immunological pathways enforces limits the host's ability to control the
Externí odkaz:
https://doaj.org/article/659ad0f61403493d8c1ebb4bb4bf1990
Autor:
Tobias Hoffmann, Peter Oelzner, Ulf Teichgräber, Marcus Franz, Nikolaus Gaßler, Claus Kroegel, Gunter Wolf, Alexander Pfeil
Publikováno v:
Frontiers in Medicine, Vol 9 (2023)
Lung involvement is the most common and serious organ manifestation in patients with inflammatory rheumatic disease (IRD). The type of pulmonary involvement can differ, but the most frequent is interstitial lung disease (ILD). The clinical manifestat
Externí odkaz:
https://doaj.org/article/268356ae887549da99f775aea235d14d