Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Nikolaus G. Greeff"'
Autor:
Nikolaus G. Greeff, Frank J.P. Kühn
In voltage-dependent sodium channels there is some functional specialization of the four different S4 voltage sensors with regard to the gating process. Whereas the voltage sensors of domains 1 to 3 control activation gating, the movement of the volt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf55a507e7351caf1f369146d54f66e
http://doc.rero.ch/record/321269/files/232_2002_Article_2004.pdf
http://doc.rero.ch/record/321269/files/232_2002_Article_2004.pdf
Publikováno v:
Biophysical Journal. 112:102a-103a
The macroscopic time courses of activation, inactivation and recovery are voltage dependent. Control of these processes on the molecular level by the voltage sensors S4 of each domain together with the DIII-IV loop (the inactivation particle) is not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c49af542f4dc42b0dc2bea702089f139
https://doi.org/10.1016/j.bpj.2016.11.587
https://doi.org/10.1016/j.bpj.2016.11.587
Publikováno v:
Biophysical Journal. 112:103a-104a
We previously identified the resting state positions of the voltage sensor S4 for each domain of Nav1.2 by means of omega mutations. We found that a double gap is needed to open the omega pore (narrow part of the gating pore) resulting in detectable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a57b3d740489a08d97d38408b31a34bd
https://doi.org/10.1016/j.bpj.2016.11.592
https://doi.org/10.1016/j.bpj.2016.11.592
Publikováno v:
Channels. 4:93-100
The aim of the present study was to investigate in detail how the voltage sensor in the Shaker potassium channel moves during the gating process. After the publication of the open channel structure from the crystallized KvAP channel in 2003, an alter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cdec44185a75c7cdb942423816d8680
https://doi.org/10.4161/chan.4.2.10672
https://doi.org/10.4161/chan.4.2.10672
Autor:
Nikolaus G. Greeff, Christophe Guionaud, Günter Scholtysik, Meike Mevissen, Helena Denac, Frank J.P. Kühn, Cornelia Kühn
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 303:89-98
Cardiac voltage-dependent sodium channels (Na(v)) are drug targets for synthetic inactivation inhibitors typified by (+/-)-4- [3-(4-diphenylmethyl-1-piperazinyl)-2-hydroxy propoxy]-1H-indole-2-carbonitrile (DPI 201-106), of which the molecular mode o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc3e1992b7cb7c7d770f6810d5b4b5a5
https://doi.org/10.1124/jpet.303.1.89
https://doi.org/10.1124/jpet.303.1.89
Autor:
Frank J.P. Kühn, Nikolaus G. Greeff
Publikováno v:
Biophysical Journal. 79(5):2434-2453
Whole-cell gating current recording from rat brain IIA sodium channels in Xenopus oocytes was achieved using a high-expression system and a newly developed high-speed two-electrode voltage-clamp. The resulting ionic currents were increased by an orde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af4999cebb884cf5eb159cf58e0558c
Publikováno v:
Biophysical Journal. 98(3)
Omega current is a cation-selective current conducted through the voltage sensor domain of ion channel when the first arginine R1 is replaced by a short residue. We were able to show Omega current for three different gaps along the voltage sensor S4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe245efda97e30cca007e9ef5e2ef88a
Publikováno v:
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 337:471-484
Comparisons were made between families of ion currents recorded in voltage-clamped squid axons dialysed with 20 mM NaF and 330 mM CsF or TMAF, and bathed in a solution in which four fifths of the Na was replaced by Tris. The permeability coefficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76fb7377c1e0cddb04d910b08a4c5351
https://doi.org/10.1098/rstb.1992.0122
https://doi.org/10.1098/rstb.1992.0122
Publikováno v:
Channels (Austin, Tex.). 4(2)
The aim of the present study was to investigate in detail how the voltage sensor in the Shaker potassium channel moves during the gating process. After the publication of the open channel structure from the crystallized K(V)AP channel in 2003, an alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::82d144a1255ba8ae6d883de6918be7de
https://pubmed.ncbi.nlm.nih.gov/20139706
https://pubmed.ncbi.nlm.nih.gov/20139706
Autor:
Dominik Grögler, Claudia Lehmann, Hansjakob Heldstab, Nikolaus G. Greeff, Tamer M. Gamal El-Din
Publikováno v:
Biophysical Journal. 96(3)
Voltage-gated ion channels sense voltage by moving arginine residues located in the S4 segment across the membrane electric field. According to the helical screw model these arginines, which gates the channel, move through a defined molecular gating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a25bb35d346803567708cd36d3eea4e