Výsledky vyhledávání - "Nikolaus Bueschke"

Plasticity in the functional properties of NMDA receptors improves motor circuit performance during severe energy stress

Autor: Nikolaus Bueschke, Min Hu, Lara Amaral-Silva, Alvaro Alvarez, Joseph M. Santin

Publikováno v: bioRxiv

Brain energy stress leads to neuronal hyperexcitability followed by a rapid loss of function and cell death. In contrast, the frog brain switches into a state of extreme metabolic resilience that allows them to maintain motor function during hypoxia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcfeeee5fe18c2179cd3b2e7f464b2ed
https://europepmc.org/articles/PMC9882286/

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Improved Hypoxia Tolerance Involves Altered NMDA Receptor Function To Oppose Hyperexcitable Network Output in Bullfrogs

Autor: Nikolaus Bueschke, Joseph Santin

Publikováno v: The FASEB Journal. 36

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5cee73605cf83e2e4a036dc622ab6613
https://doi.org/10.1096/fasebj.2022.36.s1.r3732

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Lactate ions induce synaptic plasticity to enhance output from the central respiratory network

Autor: Nikolaus Bueschke, Lara do Amaral-Silva, Min Hu, Joseph M. Santin

Publikováno v: J Physiol

Lactate ion sensing has emerged as a process that regulates ventilation during metabolic challenges. Most work has focused on peripheral sensing of lactate for the control of breathing. However, lactate also rises in the central nervous system (CNS)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b412c3378619c0884a803fff43035a
https://europepmc.org/articles/PMC8696744/

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Transforming a neural circuit to function without oxygen and glucose delivery

Autor: Nikolaus, Bueschke, Lara do, Amaral-Silva, Sasha, Adams, Joseph M, Santin

Publikováno v: Curr Biol

Disruptions in the delivery of oxygen and glucose impair the function of neural circuits, with lethal consequences commonly observed in stroke and cardiac arrest. Intense focus has been placed on understanding how to overcome neuronal failure during

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d507a64c170583d54fc6e097795ea106
https://doi.org/10.1016/j.cub.2021.11.003

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Neuromodulation or energy failure? Metabolic limitations silence network output in the hypoxic amphibian brainstem

Autor: Joseph M. Santin, Sasha Adams, Nikolaus Bueschke, Tanya Zubov

Publikováno v: Am J Physiol Regul Integr Comp Physiol

Hypoxia tolerance in the vertebrate brain often involves chemical modulators that arrest neuronal activity to conserve energy. However, in intact networks, it can be difficult to determine whether hypoxia triggers modulators to stop activity in a pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f5fbcf22a5c58f648a21362429d83f
https://pubmed.ncbi.nlm.nih.gov/33175586

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