Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Nikolaus, Heveker"'
Autor:
Anne Fougerat, Xuefang Pan, Victoria Smutova, Nikolaus Heveker, Christopher W. Cairo, Tarik Issad, Bruno Larrivée, Jeffrey A. Medin, Alexey V. Pshezhetsky
Publikováno v:
Molecular Metabolism, Vol 12, Iss , Pp 76-88 (2018)
Objectives: Neuraminidase 1 (NEU1) cleaves terminal sialic acids of glycoconjugates during lysosomal catabolism. It also modulates the structure and activity of cellular surface receptors affecting diverse pathways. Previously we demonstrated that NE
Externí odkaz:
https://doaj.org/article/541e8d755b704d37851988c197c97c88
Supplementary Figures 1-4 from Positive Feedback Activation of Estrogen Receptors by the CXCL12-CXCR4 Pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7933de4bfc013666a0fc6de4663ede5f
https://doi.org/10.1158/0008-5472.22377710
https://doi.org/10.1158/0008-5472.22377710
Autor:
Nathan Reynders, Dayana Abboud, Alessandra Baragli, Muhammad Zaeem Noman, Bernard Rogister, Simone P. Niclou, Nikolaus Heveker, Bassam Janji, Julien Hanson, Martyna Szpakowska, Andy Chevigné
Publikováno v:
Cells, Vol 8, Iss 6, p 613 (2019)
First thought to orchestrate exclusively leukocyte trafficking, chemokines are now acknowledged for their multiple roles in the regulation of cell proliferation, differentiation, and survival. Dysregulation of their normal functions contributes to va
Externí odkaz:
https://doaj.org/article/6e441390ed78493c9dbe9c21de7d9fc3
Autor:
Jeffrey A. Medin, Xuefang Pan, Victoria Smutova, Bruno Larrivée, Christopher W. Cairo, Nikolaus Heveker, Anne Fougerat, Alexey V. Pshezhetsky, Tarik Issad
Publikováno v:
Molecular Metabolism, Vol 12, Iss, Pp 76-88 (2018)
Molecular metabolism
Molecular metabolism, Elsevier, 2018, 12, pp.76-88. ⟨10.1016/j.molmet.2018.03.017⟩
Molecular Metabolism
Molecular metabolism
Molecular metabolism, Elsevier, 2018, 12, pp.76-88. ⟨10.1016/j.molmet.2018.03.017⟩
Molecular Metabolism
Objectives Neuraminidase 1 (NEU1) cleaves terminal sialic acids of glycoconjugates during lysosomal catabolism. It also modulates the structure and activity of cellular surface receptors affecting diverse pathways. Previously we demonstrated that NEU
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d25418402ba632a1e60eeca6f9e2b09
https://doi.org/10.1016/j.molmet.2018.03.017
https://doi.org/10.1016/j.molmet.2018.03.017
Autor:
Tomoko Kuroyanagi, Yuka Kobayashi, Hiroaki Ohno, Nobutaka Fujii, Kenichi Akaji, David Rhainds, Shinya Oishi, Nikolaus Heveker, Kazuya Kobayashi, Haruka Sekiguchi
Publikováno v:
Journal of Medicinal Chemistry. 61:3745-3751
The atypical chemokine receptor 3 (ACKR3)/CXC chemokine receptor 7 (CXCR7) recognizes stromal cell-derived factor 1 (SDF-1)/CXCL12 and is involved in a number of physiological and pathological processes. Here, we investigated the SAR of the component
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1024efe1537e6cf6b443707d5ff9736f
https://doi.org/10.1021/acs.jmedchem.8b00336
https://doi.org/10.1021/acs.jmedchem.8b00336
Autor:
Nikolaus Heveker, Nicolas Montpas, Véronique Pons, Gilles R.X. Hickson, Besma Benredjem, Geneviève St-Onge, David Rhainds, Mélanie Girard, Nassr Nama
Publikováno v:
The Journal of Biological Chemistry
The atypical chemokine receptor ACKR3 contributes to chemotaxis by binding, internalizing, and degrading the chemokines CXCL11 and CXCL12 to shape and terminate chemotactic gradients during development and immune responses. Although unable to trigger
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c3af4ee175ca32c1c8807ca9a8612a0
https://doi.org/10.1074/jbc.m117.814947
https://doi.org/10.1074/jbc.m117.814947
Publikováno v:
Journal of Biological Chemistry. 292:31-42
Atypical chemokine receptors do not mediate chemotaxis or G protein signaling, but they recruit arrestin. They also efficiently scavenge their chemokine ligands, thereby contributing to gradient maintenance and termination. ACKR3, also known as CXCR7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf3689ae72dca4a64a4d656f2f0516f
https://doi.org/10.1074/jbc.m116.762252
https://doi.org/10.1074/jbc.m116.762252
Autor:
Bernard Rogister, Bassam Janji, Muhammad Zaeem Noman, Nathan Reynders, Julien Hanson, Simone P. Niclou, Martyna Szpakowska, Dayana Abboud, Nikolaus Heveker, Andy Chevigné, Alessandra Baragli
Publikováno v:
Cells
Cells, Vol 8, Iss 6, p 613 (2019)
Cells, Vol 8, Iss 6, p 613 (2019)
First thought to orchestrate exclusively leukocyte trafficking, chemokines are now acknowledged for their multiple roles in the regulation of cell proliferation, differentiation, and survival. Dysregulation of their normal functions contributes to va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6f27fc283baabba4271208d0bcaac1
https://pubmed.ncbi.nlm.nih.gov/31216755
https://pubmed.ncbi.nlm.nih.gov/31216755
Autor:
Pierre Lavigne, Emanuel Escher, Christine E. Mona, Élie Besserer-Offroy, Nikolaus Heveker, Jérôme Cabana, Richard Leduc, Eric Marsault
Publikováno v:
Organic & Biomolecular Chemistry. 14:10298-10311
A combination of the CXCR4 inverse agonist T140 with N-terminal CXCL12 oligopeptides has produced the first nanomolar synthetic CXCR4 agonists. In these agonists, the inverse agonistic portion provides affinity whereas the N-terminal CXCL12 sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc37cc26d267df53e095b3284597abda
https://doi.org/10.1039/c6ob01484d
https://doi.org/10.1039/c6ob01484d
Autor:
Matthias Majetschak, Joshua J. Ziarek, Youngshim Lee, Jonathan M. Eby, Sojin Shikano, Vadim Gaponenko, Xianlong Gao, Nikolaus Heveker, Ben Hitchinson, Hazem Abdelkarim, Brian F. Volkman, Nadya I. Tarasova, Yukari Okamoto, Francois Guite-Vinet
Publikováno v:
Science signaling. 11(552)
Repeated dosing of drugs targeting G protein-coupled receptors can stimulate antagonist tolerance, which reduces their efficacy; thus, strategies to avoid tolerance are needed. The efficacy of AMD3100, a competitive antagonist of the chemokine recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfcc94a4bf22ef7f24f39220956001c5
https://pubmed.ncbi.nlm.nih.gov/30327409
https://pubmed.ncbi.nlm.nih.gov/30327409