Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Nikolas Stroth"'
Autor:
Nicoletta Schintu, Xiaoqun Zhang, Nikolas Stroth, Aleksander A. Mathé, Per E. Andrén, Per Svenningsson
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Depression is a common comorbid condition in Parkinson’s disease (PD). Patients with depression have a two-fold increased risk to develop PD. Further, depression symptoms often precede motor symptoms in PD and are frequent at all stages of the dise
Externí odkaz:
https://doaj.org/article/c42b5cd8e5b84b14ab644ee89d631dd2
Autor:
Tobias Bohnenpoll, Eric Olson, Mykola Dergai, Jennifer Cox, Simone Romoli, I-Ju Lo, Johannes Pospiech, Krishan Vishnolia, Mark Mcconnell, Marvin Gunawan, Michaela Bayerlová, Nicolette Honson, Niklas Michel, Nikolas Stroth, Olivier Radresa, Philipp Skroblin, Priyanka Kohli, Seamus Ragan, Shenshen Lai, Steven Bromidge, David Powell, Uwe Andag, Andrew King
Publikováno v:
Nephrology Dialysis Transplantation. 37
BACKGROUND Conventional stratification by clinical and histopathological phenotypes only approximates the heterogeneity of chronic kidney disease (CKD) and is insufficient to drive discovery of disease-modifying therapies or predict clinical outcomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9229435806dc92096d71084c602a577f
https://doi.org/10.1093/ndt/gfac114.004
https://doi.org/10.1093/ndt/gfac114.004
Autor:
Haiying Zhang, Li-Mei Zhang, Wenqin Xu, Lee E. Eiden, Dana Bakalar, Sean Sweat, Babru B Samal, Sunny Zhihong Jiang, Nikolas Stroth, Gunner Drossel
Publikováno v:
Psychoneuroendocrinology
Since the advent of gene knock-out technology in 1987, insight into the role(s) of neuropeptides in centrally- and peripherally-mediated physiological regulation has been gleaned by examining altered physiological functioning in mammals, predominantl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c172b59f90140f109618fa034eae1247
https://europepmc.org/articles/PMC9288801/
https://europepmc.org/articles/PMC9288801/
Autor:
Lee E. Eiden, Wenqin Xu, Sean Sweat, Dana Bakalar, Nikolas Stroth, Li-Mei Zhang, Babru B Samal, Haiying Zhang, Gunner Drossel, Sunny Zhihong Jiang
Publikováno v:
Psychoneuroendocrinology
Since the advent of gene knockout technology in 1987, insight into the role(s) of neuropeptides in centrally- and peripherally-mediated physiological regulation has been gleaned by examining altered physiological functioning in mammals, predominantly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b0963e13df0cd59cccacc08ff6ba26
https://europepmc.org/articles/PMC8900973/
https://europepmc.org/articles/PMC8900973/
Autor:
Nikolas Stroth
Publikováno v:
Science and Engineering Ethics. 22:1707-1716
The global biomedical research enterprise is driving substantial advances in medicine and healthcare. Yet it appears that the enterprise is rather wasteful, falling short of its true innovative potential. Suggested reasons are manifold and involve va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b23c7edaeccd08df1caa789d1c362b3
https://doi.org/10.1007/s11948-015-9738-x
https://doi.org/10.1007/s11948-015-9738-x
Autor:
Nicola Antonio Colabufo, Nikolas Stroth, Roberto Perrone, Marcello Leopoldo, Enza Lacivita, Per Svenningsson, Mauro Niso
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:4824-4830
G protein-coupled receptors (GPCRs) mediate biological signal transduction through complex molecular pathways. Therapeutic effects of GPCR-directed drugs are typically accompanied by unwanted side effects, owing in part to the parallel engagement of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f686437b8ce9116df6332b5bc6faa0e9
https://doi.org/10.1016/j.bmc.2015.05.042
https://doi.org/10.1016/j.bmc.2015.05.042
Autor:
Agnete Dyssegaard, Jesper L. Kristensen, Hanne D. Hansen, Szabolcs Lehel, Matthias M. Herth, Gitte M. Knudsen, Janus H. Magnussen, Nikolas Stroth, Valdemar L. Andersen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:1901-1904
E-55888 has been identified as a selective serotonin 7 (5-HT 7 ) receptor agonist. In this study, we describe the synthesis, radiolabeling and in vivo evaluation of [ 11 C]E-55888 as a radioligand for positron emission tomography (PET) imaging. [ 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b2e4893f4eebadbceda4d98e762faa
https://doi.org/10.1016/j.bmcl.2015.03.039
https://doi.org/10.1016/j.bmcl.2015.03.039
Autor:
Nikolas Stroth, Matthias M. Herth, Gitte M. Knudsen, Szabolcs Lehel, Agnete Dyssegaard, Jesper L. Kristensen, Balázs Volk, Anders Ettrup, Hanne D. Hansen, Valdemar L. Andersen, Per Svenningsson
Publikováno v:
Journal of Medicinal Chemistry. 58:3631-3636
We have investigated several oxindole derivatives in the pursuit of a 5-HT7 receptor PET ligand. Herein the synthesis, chiral separation, and pharmacological profiling of two possible PET candidates toward a wide selection of CNS-targets are detailed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb73c12c5ed5b127e8381080116bdf30
https://doi.org/10.1021/acs.jmedchem.5b00095
https://doi.org/10.1021/acs.jmedchem.5b00095
Publikováno v:
Journal of Neurochemistry. 124:410-417
G protein-coupled receptor 37 (GPR37) is suggested to be implicated in the pathogenesis of Parkinson's disease and is accumulating in Lewy bodies within afflicted brain regions. Over-expressed GPR37 is prone to misfolding and aggregation, causing cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef7814da9ec9b0e7758c4b0a647e40c
https://doi.org/10.1111/jnc.12081
https://doi.org/10.1111/jnc.12081
Autor:
Per Svenningsson, Marcello Leopoldo, Antonia Caroli, Daniela Patarnello, Nicola Antonio Colabufo, Peter B. Hedlund, Pantaleo Di Pilato, Nikolas Stroth, Paola De Giorgio, Mauro Niso, Enza Lacivita, Francesco Berardi, Marialessandra Contino, Roberto Perrone
Publikováno v:
Journal of Medicinal Chemistry. 55:6375-6380
Here we report the design, synthesis, and 5-HT(7) receptor affinity of a set of 1-(3-biphenyl)- and 1-(2-biphenyl)piperazines. The effect on 5-HT(7) affinity of various substituents on the second (distal) phenyl ring was analyzed. Several compounds s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f30904e6fd1b25ea2f0dfa51e4eb3c2
https://doi.org/10.1021/jm3003679
https://doi.org/10.1021/jm3003679