Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Nikolas R, Burton"'
Autor:
Nikolas R. Burton, Keriann M. Backus
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Mapping the ligandability or potential druggability of all proteins in the human proteome is a central goal of mass spectrometry-based covalent chemoproteomics. Achieving this ambitious objective requires high throughput and high coverage sa
Externí odkaz:
https://doaj.org/article/5c9a1665fc4442f3852c0596e4439907
Autor:
Tianyang Yan, Andrew B. Palmer, Daniel J. Geiszler, Daniel A. Polasky, Lisa M. Boatner, Nikolas R. Burton, Ernest Armenta, Alexey I. Nesvizhskii, Keriann M. Backus
Publikováno v:
Analytical Chemistry. 94:3800-3810
Mass spectrometry-based chemoproteomics has enabled functional analysis and small molecule screening at thousands of cysteine residues in parallel. Widely adopted chemoproteomic sample preparation workflows rely on the use of pan cysteine-reactive pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dadd80a4e1f19030a0ef65033e33ca8
https://doi.org/10.1021/acs.analchem.1c04402
https://doi.org/10.1021/acs.analchem.1c04402
Autor:
Roger Machín Rivera, Nikolas R. Burton, Luke D. Call, Marshall A. Tomat, Vincent N. G. Lindsay
Publikováno v:
Org Lett
Pericyclic processes such as [3,3]-sigmatropic rearrangements leading to the rapid generation of molecular complexity constitute highly valuable tools in organic synthesis. Herein, we report the formation of particularly hindered tertiary alcohols vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc66087fd59f720f055892074a85d9f2
https://europepmc.org/articles/PMC9502203/
https://europepmc.org/articles/PMC9502203/
Autor:
Jason Wu, Allison S. Hacker, Ohyun Kwon, Nikolas R Burton, Jason C. Quintana, Andrew J. Smaligo, Ruoxi Wang, Changmin Xie, Aslam C. Shaikh
Publikováno v:
Angewandte Chemie International Edition. 59:1211-1215
Reported herein is a one-pot protocol for the oxodealkenylative introduction of carbonyl functionalities into terpenes and terpene-derived compounds. This transformation proceeds by Criegee ozonolysis of an alkene, reductive cleavage of the resulting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b66413c41c6145e8bbd101a94a118dc
https://doi.org/10.1002/anie.201913201
https://doi.org/10.1002/anie.201913201
Autor:
Jian Cao, Lisa M Boatner, Keriann M. Backus, Heta S Desai, Ernest Armenta, Nikolas R Burton, Neil J. Chan, Jose Omar Castellon
Publikováno v:
Anal Chem
Mass-spectrometry-based chemoproteomics has enabled the rapid and proteome-wide discovery of functional and potentially 'druggable' hotspots in proteins. While numerous transformations are now available, chemoproteomic studies still rely overwhelming
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30fb40882db17d2e87f23da2924a4618
https://europepmc.org/articles/PMC8849040/
https://europepmc.org/articles/PMC8849040/
Autor:
Andrew J, Smaligo, Jason, Wu, Nikolas R, Burton, Allison S, Hacker, Aslam C, Shaikh, Jason C, Quintana, Ruoxi, Wang, Changmin, Xie, Ohyun, Kwon
Publikováno v:
Angew Chem Int Ed Engl
Reported herein is a one-pot protocol for the oxodealkenylative introduction of carbonyl functionalities into terpenes and terpene-derived compounds. This transformation proceeds by Criegee ozonolysis of an alkene, reductive cleavage of the resulting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd569a9cef81545f487d0bb50df32c7f
https://pubmed.ncbi.nlm.nih.gov/31692203
https://pubmed.ncbi.nlm.nih.gov/31692203