Výsledky vyhledávání - "Nikolas Merlock"

Akademický článek

A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy

Autor: Zane R. Lybrand, Sonal Goswami, Jingfei Zhu, Veronica Jarzabek, Nikolas Merlock, Mahafuza Aktar, Courtney Smith, Ling Zhang, Parul Varma, Kyung-Ok Cho, Shaoyu Ge, Jenny Hsieh

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Adult-born granule cells integrate in hippocampal circuitry and contribute to hippocampal function. Here, the authors show that a critical period of neuronal activity regulates aberrant neurogenesis to rewire hippocampal circuitry and drive seizures

Externí odkaz: https://doaj.org/article/cd230e45dae0415ca0fb2fb0eaf34de2

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Understanding Primary Blast Injury: High Frequency Pressure Acutely Disrupts Neuronal Network Dynamics in Cerebral Organoids

Autor: Marc Joshua Silvosa, Nohemi Romo Mercado, Nikolas Merlock, Suhas Vidhate, Ricardo Mejia-Alvarez, Tony T. Yuan, Adam M. Willis, Zane R. Lybrand

Publikováno v: Journal of neurotrauma. 39(21-22)

Blast exposure represents a common occupational risk capable of generating mild to severe traumatic brain injuries (TBI). During blast exposure, a pressure shockwave passes through the skull and exposes brain tissue to complex pressure waveforms. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29fb6b8857129c114c9f464039e2c844
https://pubmed.ncbi.nlm.nih.gov/35765922

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A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy

Autor: Sonal Goswami, Mahafuza Aktar, Kyung-Ok Cho, Veronica Jarzabek, Zane R. Lybrand, Jenny Hsieh, Shaoyu Ge, Jingfei Zhu, Nikolas Merlock, Ling Zhang, Courtney Smith, P. Varma

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

In the mammalian hippocampus, adult-born granule cells (abGCs) contribute to the function of the dentate gyrus (DG). Disruption of the DG circuitry causes spontaneous recurrent seizures (SRS), which can lead to epilepsy. Although abGCs contribute to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b91adf77bc028f56bf2432b9289e428f
http://europepmc.org/articles/PMC7930276

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