Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Nikolas Maniatis"'
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background The cost-free increase in statistical power of using imputation to infer missing genotypes is undoubtedly appealing, but is it hazard-free? This case study of three type-2 diabetes (T2D) loci demonstrates that it is not; it sheds
Externí odkaz:
https://doaj.org/article/b2b5c309fdfe45f3826f8faec9bad368
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
This study investigated the potential genetic mechanisms which underlie adipose tissue mitochondrial dysfunction in Type 2 diabetes (T2D), by systematically identifying nuclear-encoded mitochondrial genes (NEMGs) among the genes regulated by T2D-asso
Externí odkaz:
https://doaj.org/article/bbdd9c2c38fd400a9beb13e676764087
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46021 (2012)
Anthocyanin content is a trait of major interest in Vitis vinifera L. These compounds affect grape and wine quality, and have beneficial effects on human health. A candidate-gene approach was used to identify genetic variants associated with anthocya
Externí odkaz:
https://doaj.org/article/23edf9a35b7f41fd8ebc856eada49c49
Autor:
Toby Andrew, Nikolas Maniatis, Francis Carbonaro, S H Melissa Liew, Winston Lau, Tim D Spector, Christopher J Hammond
Publikováno v:
PLoS Genetics, Vol 4, Iss 10, p e1000220 (2008)
Refractive error is a highly heritable quantitative trait responsible for considerable morbidity. Following an initial genome-wide linkage study using microsatellite markers, we confirmed evidence for linkage to chromosome 3q26 and then conducted fin
Externí odkaz:
https://doaj.org/article/a649827c8f7b42f583f52003f218ff70
Publikováno v:
Frontiers in Endocrinology
Frontiers in Endocrinology, Vol 12 (2021)
Frontiers in Endocrinology, Vol 12 (2021)
This study investigated the potential genetic mechanisms which underlie adipose tissue mitochondrial dysfunction in Type 2 diabetes (T2D), by systematically identifying nuclear-encoded mitochondrial genes (NEMGs) among the genes regulated by T2D-asso
Publikováno v:
Annals of human geneticsREFERENCES. 86(1)
Although imputation of missing SNP results has been widely used in genetic studies, claims about the quality and usefulness of imputation have outnumbered the few studies that have questioned its limitations. But it is becoming clear that these limit
Autor:
Rosemary Ekong, Andrew Pomiankowski, Nikolas Maniatis, Nick Lane, Mark G. Thomas, Adam Rutherford, Catherine C Walker, Lucy van Dorp, Dallas M. Swallow, Steve Jones
Publikováno v:
Nature. 580(7803)
Autor:
Saioa López, Pascale Gerbault, Anke Liebert, Bryony L. Jones, Mark G. Thomas, Winston Lau, Nicolas Montalva, Dallas M. Swallow, Nikolas Maniatis, Neil Bradman
Publikováno v:
Human Genetics
The genetic trait of lactase persistence (LP) is associated with at least five independent functional single nucleotide variants in a regulatory region about 14 kb upstream of the lactase gene [−13910*T (rs4988235), −13907*G (rs41525747), −1391
Interpretation of results from genome-wide association studies for T2D is challenging. Only very few loci have been replicated in African ancestry populations and the identification of the implicated functional genes remain largely undefined. We used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf238e93c9aa383b8df02d14f3eab5db
http://hdl.handle.net/10044/1/49134
http://hdl.handle.net/10044/1/49134
Publikováno v:
The American Journal of Human Genetics. 92(1):107-113
The risk of Crohn disease (CD) has a large genetic component. A recent meta-analysis of 6 genome-wide association studies reported 71 chromosomal intervals but does not account for all of the known genetic contribution. Here, we refine localization o