Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Nikolas A. Savage"'
Autor:
Michael J. Romanowski, William C. Forrester, David Remillard, Jason R. Thomas, Helen Trinh Pham, Joshiawa Paulk, Edmund Harrington, Patricia A. Horton, Jason Murphy, Matthew B. Maxwell, Xin Chen, Nikolas A. Savage, Igor Maksimovic, Francisco J. Garcia, Alexia T. Kedves, Markus Schirle
Publikováno v:
ACS Chemical Biology. 16:2185-2192
Bromodomain-containing proteins frequently reside in multisubunit chromatin complexes with tissue or cell state-specific compositions. Recent studies have revealed tumor-specific dependencies on the BAF complex bromodomain subunit BRD9 that are a res
Publikováno v:
Tetrahedron. 70:4135-4146
A concise approach to access functionalized benzocyclobutenones from 3-halophenol derivatives is described. This modified synthesis employs a [2+2] cycloaddition between benzynes generated from dehydrohalogenation of aryl halides using LiTMP and acet
Publikováno v:
Angewandte Chemie International Edition. 53:1891-1895
We describe a rhodium-catalyzed all-carbon spirocenter formation through a decarbonylative coupling of trisubstituted cyclic olefins and benzocyclobutenones via C–C activation. A [Rh(CO)2Cl]2/P(C6F5)3 metal-ligand combination was found to catalyze
Publikováno v:
Journal of the American Chemical Society. 134:20005-20008
Here we report the first highly enantioselective Rh-catalyzed carboacylation of olefins via C-C bond activation of benzocyclobutenones. Good yields and excellent enantioselectivities (92-99% ee, 14 examples) were obtained for substrates with various
Publikováno v:
ChemInform. 45
A modified access to the benzocyclobutene motif via [2 + 2] cycloaddition between benzynes generated from dehydrohalogenation of aryl halides and acetaldehyde enolate in situ generated from THF is presented.
Publikováno v:
ChemInform. 45
A range of diverse spirocycles are synthesized in good to excellent yields and many sensitive functional groups are tolerated.
Publikováno v:
ChemInform. 44
Here we report the first highly enantioselective Rh-catalyzed carboacylation of olefins via C–C bond activation of benzocyclobutenones. Good yields and excellent enantioselectivities (92–99% ee, 14 examples) were obtained for substrates with vari