Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Nikolaos Meimetis"'
Autor:
Nikolaos Meimetis, Krista M. Pullen, Daniel Y. Zhu, Avlant Nilsson, Trong Nghia Hoang, Sara Magliacane, Douglas A. Lauffenburger
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-19 (2024)
Abstract The development of therapeutics and vaccines for human diseases requires a systematic understanding of human biology. Although animal and in vitro culture models can elucidate some disease mechanisms, they typically fail to adequately recapi
Externí odkaz:
https://doaj.org/article/d709836e3f53497f9d22e8848afa7d5b
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109509- (2024)
Summary: Many diseases emerge from dysregulated cellular signaling, and drugs are often designed to target specific signaling proteins. Off-target effects are, however, common and may ultimately result in failed clinical trials. Here we develop a com
Externí odkaz:
https://doaj.org/article/e27deefd60e146d69deed574cc746216
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Many diseases are caused by disruptions to the network of biochemical reactions that allow cells to respond to external signals. Here Nilsson et al develop a method to simulate cellular signaling using artificial neural networks to predict cellular r
Externí odkaz:
https://doaj.org/article/a431ee9dd0cf46e596b2b786b137e648
Autor:
Christos Fotis, Nikolaos Meimetis, Nikos Tsolakos, Marianna Politou, Karolina Akinosoglou, Vaia Pliaka, Angeliki Minia, Evangelos Terpos, Ioannis P. Trougakos, Andreas Mentis, Markos Marangos, George Panayiotakopoulos, Meletios A. Dimopoulos, Charalampos Gogos, Alexandros Spyridonidis, Leonidas G. Alexopoulos
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract There is a plethora of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) serological tests based either on nucleocapsid phosphoprotein (N), S1-subunit of spike glycoprotein (S1) or receptor binding domain (RBD). Although these sin
Externí odkaz:
https://doaj.org/article/858a40ad7d234e85a90d69d2e74774df
Autor:
Christos Fotis, Leonidas G. Alexopoulos, Christina Koleri, Thomas Gkekas, George Alevizos, Nikolaos Meimetis
MotivationThe analysis and comparison of compounds’ transcriptomic signatures can help elucidate a compound’s Mechanism of Action (MoA) in a biological system. In order to take into account the complexity of the biological system, several computa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebe545563a3adbf90bd874df1d1a79c4
https://doi.org/10.1101/2021.11.29.470365
https://doi.org/10.1101/2021.11.29.470365
Publikováno v:
Nature communications. 13(1)
Mammalian cells adapt their functional state in response to external signals in form of ligands that bind receptors on the cell-surface. Mechanistically, this involves signal-processing through a complex network of molecular interactions that govern
Autor:
George Panayiotakopoulos, Vaia Pliaka, Marianna Politou, Nikolaos Meimetis, Christos Fotis, Charalampos Gogos, Leonidas G. Alexopoulos, Meletios A. Dimopoulos, Nikos Tsolakos, Andreas Mentis, Evangelos Terpos, Ioannis P. Trougakos, Angeliki Minia, Alexandros Spyridonidis, Markos Marangos, Karolina Akinosoglou
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
There is a plethora of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) serological tests based either on nucleocapsid phosphoprotein (N), S1-subunit of spike glycoprotein (S1) or receptor binding domain (RBD). Although these single-antig
Autor:
Andreas Mentis, Christos Fotis, Angeliki Minia, Marianna Politou, Ioannis P. Trougakos, Charalampos Gogos, Leonidas G. Alexopoulos, Meletios A. Dimopoulos, Nikos Tsolakos, Markos Marangos, Evangelos Terpos, Nikolaos Meimetis, Karolina Akinosoglou, Alexandros Spyridonidis, George Panayiotakopoulos, Vicky Pliaka
More than 300 SARS-COV-2 serological tests have recently been developed using either the nucleocapsid phosphoprotein (N), the spike glycoprotein subunit (S1), and more recently the receptor binding domain (RBD). Most of the assays report very good cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b870285f0b4540cf0c950c7c7abc6ca8
https://doi.org/10.1101/2020.09.09.20191122
https://doi.org/10.1101/2020.09.09.20191122