Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Nikolaos Lougiakis"'
Autor:
Sophia Magkouta, Dimitris Veroutis, Athanasios Pousias, Angelos Papaspyropoulos, Kety Giannetti, Natassa Pippa, Nikolaos Lougiakis, Konstantinos Kambas, Nefeli Lagopati, Aikaterini Polyzou, Maria Georgiou, Maria Chountoulesi, Stergios Pispas, Spyros Foutadakis, Efthymios Kyrodimos, Nicole Pouli, Panagiotis Marakos, Athanassios Kotsinas, Panayotis Verginis, Dimitrios Valakos, Giannis Vatsellas, Russell Petty, Dimitris Thanos, Marco Demaria, Konstantinos Evangelou, Raffaella Di Micco, Vassilis G. Gorgoulis
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102929- (2024)
Summary: Identification and isolation of senescent cells is challenging, rendering their detailed analysis an unmet need. We describe a precise one-step protocol to fluorescently label senescent cells, for flow cytometry and fluorescence microscopy,
Externí odkaz:
https://doaj.org/article/ed81a3ca446743eca624a9664aad2cf8
Autor:
Maria Georgiou, Nikolaos Lougiakis, Roxane Tenta, Katerina Gioti, Stavroula Baritaki, Lydia-Evangelia Gkaralea, Elisavet Deligianni, Panagiotis Marakos, Nicole Pouli, Dimitris Stellas
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 787 (2023)
Purine analogues are important therapeutic tools due to their affinity to enzymes or receptors that are involved in critical biological processes. In this study, new 1,4,6-trisubstituted pyrazolo[3,4-b]pyridines were designed and synthesized, and the
Externí odkaz:
https://doaj.org/article/b77245d7c6e6463fb9eb7fdfacef7322
Autor:
Nemanja Djokovic, Minna Rahnasto-Rilla, Nikolaos Lougiakis, Maija Lahtela-Kakkonen, Katarina Nikolic
Publikováno v:
Pharmaceuticals, Vol 16, Iss 1, p 127 (2023)
A growing body of preclinical evidence recognized selective sirtuin 2 (SIRT2) inhibitors as novel therapeutics for treatment of age-related diseases. However, none of the SIRT2 inhibitors have reached clinical trials yet. Transformative potential of
Externí odkaz:
https://doaj.org/article/f55b933ed78f40a9b3dce08e0eea9225
Autor:
Spyridon Dimitrakis, Efthymios-Spyridon Gavriil, Athanasios Pousias, Nikolaos Lougiakis, Panagiotis Marakos, Nicole Pouli, Katerina Gioti, Roxane Tenta
Publikováno v:
Molecules, Vol 27, Iss 1, p 247 (2021)
A number of pyrrolo[2,3-c]pyridines, pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]pyrimidines were designed and synthesized as antiproliferative agents. The target compounds possessed selected substituents in analogous positions on the central scaffo
Externí odkaz:
https://doaj.org/article/a14537df610049a1b3be593f82cafac5
Autor:
Georgios Papadakis, Maria Gerasi, Robert Snoeck, Panagiotis Marakos, Graciela Andrei, Nikolaos Lougiakis, Nicole Pouli
Publikováno v:
Molecules, Vol 25, Iss 19, p 4531 (2020)
The strong inhibition of Human Cytomegalovirus (HCMV) replication by benzimidazole nucleosides, like Triciribine and Maribavir, has prompted us to expand the structure–activity relationships of the benzimidazole series, using as a central core the
Externí odkaz:
https://doaj.org/article/c0acce70a16840228f9e986f7abe881c
Autor:
Anna-Maria Fantel, Vassilios Myrianthopoulos, Anastasios Georgoulis, Nikolaos Lougiakis, Iliana Zantza, George Lamprinidis, Fiona Augsburger, Panagiotis Marakos, Constantinos E. Vorgias, Csaba Szabo, Nicole Pouli, Andreas Papapetropoulos, Emmanuel Mikros
Publikováno v:
Molecules, Vol 25, Iss 16, p 3739 (2020)
Cystathionine β-synthase (CBS) is a key enzyme in the production of the signaling molecule hydrogen sulfide, deregulation of which is known to contribute to a range of serious pathological states. Involvement of hydrogen sulfide in pathways of param
Externí odkaz:
https://doaj.org/article/2b605ffe26ba4b6aac08ee8d28bdbe83
Autor:
Margarita Stampelou, Anna Suchankova, Efpraxia Tzortzini, Lakshiv Dhingra, Kerry Barkan, Nikolaos Lougiakis, Panagiotis Marakos, Nicole Pouli, Graham Ladds, Antonios Kolocouris
Publikováno v:
Journal of Medicinal Chemistry. 65:13305-13327
Drugs targeting adenosine receptors (AR) can provide treatment for diseases. We report the identification of 7-(phenylamino)-pyrazolo[3,4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6cbf037699932a3c0db6add10cb34c7
https://doi.org/10.1021/acs.jmedchem.2c01123
https://doi.org/10.1021/acs.jmedchem.2c01123
Autor:
Anna Suchankova, Margarita Stampelou, Klontiana Koutsouki, Athanasios Pousias, Lakshiv Dhingra, Kerry Barkan, Nicole Pouli, Panagiotis Marakos, Roxane Tenta, Antonios Kolocouris, Nikolaos Lougiakis, Graham Ladds
Publikováno v:
ACS Medicinal Chemistry Letters. 13:923-934
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dd741dab512bf598fa4a68699eeb8eb
https://doi.org/10.1021/acsmedchemlett.2c00052
https://doi.org/10.1021/acsmedchemlett.2c00052
Autor:
Nikolaos Lougiakis, Nikolaos Sakalis, Maria Georgiou, Panagiotis Marakos, Nicole Pouli, Alexios-Leandros Skaltsounis, Eleni Mavrogonatou, Harris Pratsinis, Dimitris Kletsas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::694d994578635ee5027842db9906f3d8
https://doi.org/10.2139/ssrn.4454236
https://doi.org/10.2139/ssrn.4454236
Autor:
Roxane Tenta, Alexios-Leandros Skaltsounis, Katerina Gioti, David Horne, Ioannis K. Kostakis, Vassiliki Giannouli, Sangkil Nam, Nikolaos Lougiakis, Nicole Pouli, Panagiotis Marakos
Publikováno v:
Medicinal Chemistry. 16:176-191
Background: Purine isosteres are often endowed with interesting pharmacological properties, due to their involvement in cellular processes replacing the natural purines. Among these compounds, pyrazolopyridines are under active investigation for pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcae3354cc581757fd4164ce35777c48
https://doi.org/10.2174/1573406415666190222130225
https://doi.org/10.2174/1573406415666190222130225