Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Nikolaos Kouvatsos"'
Autor:
Sara Caxaria, Nikolaos Kouvatsos, Suzanne E Eldridge, Mario Alvarez‐Fallas, Anne‐Sophie Thorup, Daniela Cici, Aida Barawi, Ammaarah Arshed, Danielle Strachan, Giulia Carletti, Xinying Huang, Sabah Bharde, Melody Deniz, Jacob Wilson, Bethan L Thomas, Costantino Pitzalis, Francesco Paolo Cantatore, Manasi Sayilekshmy, Shafaq Sikandar, Frank P Luyten, Thomas Pap, Joanna C Sherwood, Anthony J Day, Francesco Dell'Accio
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 1, Pp n/a-n/a (2023)
Abstract We showed that the chemokine receptor C‐X‐C Motif Chemokine Receptor 2 (CXCR2) is essential for cartilage homeostasis. Here, we reveal that the CXCR2 ligand granulocyte chemotactic protein 2 (GCP‐2) was expressed, during embryonic deve
Externí odkaz:
https://doaj.org/article/c6ccca64be374eba90196cda5f86dbe7
Autor:
Anthony J. Day, Douglas P. Dyer, Nikolaos Kouvatsos, Leela C Biant, Jennifer M. Thomson, Caroline M. Milner, Andrew Price, Sanjay Anand, Eckart Bartnik, Jenny L Scott, Matthias Herrmann, Sheona P Drummond, Thomas Leeuw
Publikováno v:
Osteoarthritis and Cartilage.
ObjectivesTo investigate the role of endogenous TSG-6 in human osteoarthritis (OA) and assess the disease-modifying potential of a TSG-6-based biological treatment in cell, explant and animal models of OA.MethodsKnee articular cartilages from OA pati
Autor:
Joo Youn Oh, Jin Suk Ryu, Hyeon Ji Kim, Nikolaos Kouvatsos, Rebecca J. Dodd, Se Hyun Choi, Yu Jeong Kim, Caroline M. Milner, Anthony J. Day
Publikováno v:
Oh, J Y, Ryu, J S, Kim, H J, Kouvatsos, N, Dodd, R J, Choi, S H, Kim, Y J, Milner, C M & Day, A J 2022, ' The Link module of human TSG-6 (Link_TSG6) promotes wound healing, suppresses inflammation and improves glandular function in mouse models of Dry Eye Disease ', The ocular surface, vol. 24, pp. 40-50 . https://doi.org/10.1016/j.jtos.2021.12.012
PurposeTo investigate the potential of the Link_TSG6 polypeptide comprising the Link module of human TSG-6 (TNF-stimulated gene/protein-6) as a novel treatment for dry eye disease (DED).MethodsWe analyzed the therapeutic effects of topical applicatio
Autor:
Socrates J. Tzartos, Petros Giastas, Nikolaos Kouvatsos, Cornelia Poulopoulou, Dafni Chroni-Tzartou
In this study we report the X-ray crystal structure of the extracellular domain (ECD) of the human neuronal α2 nicotinic acetylcholine receptor (nAChR) subunit in complex with the agonist epibatidine at 3.2 A. Interestingly, α2 was crystallized as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::195e5045add783aa0d9a8d4630539e55
https://europepmc.org/articles/PMC5003238/
https://europepmc.org/articles/PMC5003238/
Autor:
Kathryn Ball, Mark S. Searle, Nikolaos Kouvatsos, Neil J. Oldham, Victoria Thurston, Neil R. Thomas
Publikováno v:
Journal of Molecular Biology. 371:1365-1377
The intracellular ileal lipid binding proteins (ILBPs) are involved in the transport and enterohepatic circulation of bile acids. ILBPs from different species show high sequence and structural homology and have been shown to bind multiple bile acid l
Autor:
Konstantinos Poulas, Socrates J. Tzartos, Elias Eliopoulos, Paraskevi Zisimopoulou, Nikolaos Kouvatsos, Athanasios Niarchos
Publikováno v:
International journal of biological macromolecules. 70
Nicotinic acetylcholine receptors (nAChR) are abundant in the brain and are essential in cognitive function, learning and memory. Previous efforts on α4β2 nAChR had been focused on functional and pharmacological characterization, where high express
Publikováno v:
Chemical communications (Cambridge, England). (44)
We have engineered a variant of the beta-clam shell protein ILBP which lacks the alpha-helical motif that caps the central binding cavity; the mutant protein is sufficiently destabilised that it is unfolded under physiological conditions, however, it