Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Nikolaos Dedousis"'
Autor:
Lihong Teng, Nikolaos Dedousis, Aneseh Adeshirlarijaney, Jitendra S. Kanshana, Min Liu, Craig A. Hodges, Alison B. Kohan
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 7, Pp 100551- (2024)
Intestinal disease is one of the earliest manifestations of cystic fibrosis (CF) in children and is closely tied to deficits in growth and nutrition, both of which are directly linked to future mortality. Patients are treated aggressively with pancre
Externí odkaz:
https://doaj.org/article/72f2fbe2da2242fd94f8dfa376389aed
Autor:
Bingxian Xie, Anjana Murali, Amber M. Vandevender, Jeffrey Chen, Agustin Gil Silva, Fiona M. Bello, Byron Chuan, Harinath Bahudhanapati, Ian Sipula, Nikolaos Dedousis, Faraaz A. Shah, Christopher P. O’Donnell, Jonathan K. Alder, Michael J. Jurczak
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105569- (2022)
Summary: Growth differentiation factor 15 (GDF15) is a stress-induced secreted protein whose circulating levels are increased in the context of obesity. Recombinant GDF15 reduces body weight and improves glycemia in obese models, which is largely att
Externí odkaz:
https://doaj.org/article/be2159910df74c8da53dc69784e093fc
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 11, Pp 100284- (2022)
The intestine plays a crucial role in regulating whole-body lipid metabolism through its unique function of absorbing dietary fat. In the small intestine, absorptive epithelial cells emulsify hydrophobic dietary triglycerides (TAGs) prior to secretin
Externí odkaz:
https://doaj.org/article/c7e30da86ac84ddf9cfd7c3fd655dc1a
Autor:
Frances R Belmonte, Nikolaos Dedousis, Ian Sipula, Nikita A Desai, Aatur D Singhi, Yanxia Chu, Yingze Zhang, Sylvie Bannwarth, Véronique Paquis-Flucklinger, Lea Harrington, Sruti Shiva, Michael J Jurczak, Robert M O'Doherty, Brett A Kaufman
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0203101 (2019)
Petite Integration Factor 1 (PIF1) is a multifunctional helicase present in nuclei and mitochondria. PIF1 knock out (KO) mice exhibit accelerated weight gain and decreased wheel running on a normal chow diet. In the current study, we investigated whe
Externí odkaz:
https://doaj.org/article/0257a012d4cf43d6868160c11cb2075b
Autor:
BINGXIAN XIE, ANJANA MURALI, AMBER VANDEVENDER, AGUSTIN A. GIL SILVA, FIONA BELLO, IAN J. SIPULA, NIKOLAOS DEDOUSIS, JONATHAN ALDER, MICHAEL J. JURCZAK
Publikováno v:
Diabetes. 71
Growth and differentiation factor 15 (GDF15) is a stress-induced secreted protein whose plasma levels are increased in obese patients. Recombinant GDF15 reduces body weight (BW) and improves glycemia in obese models, which is largely attributed to ce
Autor:
Edgard M. Mejia, Grant M. Hatch, Xianlin Han, Vernon W. Dolinsky, Laura K. Cole, Marilyne Vandel, Genevieve C. Sparagna, Brett A. Kaufman, Nikolaos Dedousis, Bo Xiang
Publikováno v:
Journal of molecular and cellular cardiology. 144
Cardiolipin (CL) is a unique tetra-acyl phospholipid localized to the inner mitochondrial membrane and essential for normal respiratory function. It has been previously reported that the failing human heart and several rodent models of cardiac pathol
Autor:
Robert M. O'Doherty, Ian Sipula, Nikolaos Dedousis, Anantha S. Metlakunta, Wan Huang, Maja Stefanovic-Racic
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 312:E11-E18
Leptin has potent effects on lipid metabolism in a number of peripheral tissues. In liver, an acute leptin infusion (~120 min) stimulates hepatic fatty acid oxidation (~30%) and reduces triglycerides (TG, ~40%), effects that are dependent on phosphoi
Autor:
Robert M. O'Doherty, Nikita Desai, Yanxia Chu, Michael J. Jurczak, Frances Belmonte, Nikolaos Dedousis, Yingze Zhang, Sylvie Bannwarth, Ian Sipula, Brett A. Kaufman, Véronique Paquis-Flucklinger, Lea Harrington, Aatur D. Singhi
Petite Integration Factor 1 (PIF1) is a multifunctional helicase present in nuclei and mitochondria. PIF1 knock out (KO) mice exhibit accelerated weight gain and decreased wheel running on a normal chow diet. In the current study, we investigated whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59168392c4b16566d790dd9f8f29ce2e
https://doi.org/10.1101/393355
https://doi.org/10.1101/393355
Autor:
Gabriele Schoiswohl, Laura C. Alonso, Maja Stefanovic-Racic, Robert M. O'Doherty, Erin E. Kershaw, Nikolaos Dedousis, Chao Wu, Eric E. Kelley, Daniel B. Harmon, Christopher P. O'Donnell, Ian Sipula
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 315(5)
Accumulation of myeloid cells in the liver, notably dendritic cells (DCs) and monocytes/macrophages (MCs), is a major component of the metainflammation of obesity. However, the mechanism(s) stimulating hepatic DC/MC infiltration remain ill defined. H
Autor:
Lea Harrington, Yingze Zhang, Yanxia Chu, Sylvie Bannwarth, Ian Sipula, Robert M. O'Doherty, Sruti Shiva, Nikita Desai, Frances Belmonte, Véronique Paquis-Flucklinger, Michael J. Jurczak, Brett A. Kaufman, Nikolaos Dedousis, Aatur D. Singhi
Publikováno v:
PLoS ONE
PLoS ONE, Public Library of Science, 2019, 14 (5), pp.e0203101. ⟨10.1371/journal.pone.0203101⟩
PLoS ONE, Vol 14, Iss 5, p e0203101 (2019)
PLoS ONE, 2019, 14 (5), pp.e0203101. ⟨10.1371/journal.pone.0203101⟩
PLoS ONE, Public Library of Science, 2019, 14 (5), pp.e0203101. ⟨10.1371/journal.pone.0203101⟩
PLoS ONE, Vol 14, Iss 5, p e0203101 (2019)
PLoS ONE, 2019, 14 (5), pp.e0203101. ⟨10.1371/journal.pone.0203101⟩
International audience; Petite Integration Factor 1 (PIF1) is a multifunctional helicase present in nuclei and mitochondria. PIF1 knock out (KO) mice exhibit accelerated weight gain and decreased wheel running on a normal chow diet. In the current st