Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Nikolaos A. Patsopoulos"'
Autor:
Michael H. Guo, Prashanth Sama, Brenna A. LaBarre, Hrishikesh Lokhande, John Balibalos, Ci Chu, Xiaomi Du, Pouya Kheradpour, Charles C. Kim, Taylor Oniskey, Thomas Snyder, Damien Z. Soghoian, Howard L. Weiner, Tanuja Chitnis, Nikolaos A. Patsopoulos
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-23 (2022)
Abstract Background Multiple sclerosis (MS) is an autoimmune condition of the central nervous system with a well-characterized genetic background. Prior analyses of MS genetics have identified broad enrichments across peripheral immune cells, yet the
Externí odkaz:
https://doaj.org/article/b853f835c3b7425b97ee266ce7fa4c92
Autor:
Li Dai, Mayuko Uehara, Xiaofei Li, Brenna A. LaBarre, Naima Banouni, Takaharu Ichimura, Melissa M. Lee-Sundlov, Vivek Kasinath, Jade A. Sullivan, Heyu Ni, Francesca Barone, Silvia Giannini, Baharak Bahmani, Peter T. Sage, Nikolaos A. Patsopoulos, George C. Tsokos, Jonathan S. Bromberg, Karin Hoffmeister, Liwei Jiang, Reza Abdi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Lymph nodes (LNs) are the critical sites of immunity, and the stromal cells of LNs are crucial to their function. Our understanding of the stromal compartment of the LN has deepened recently with the characterization of nontraditional stromal cells.
Externí odkaz:
https://doaj.org/article/3dc4347bd1d44db88e9d3b536cdd3e39
Autor:
Nathan Nakatsuka, Nick Patterson, Nikolaos A. Patsopoulos, Nicolas Altemose, Arti Tandon, Ashley H. Beecham, Jacob L. McCauley, Noriko Isobe, Stephen Hauser, Philip L. De Jager, David A. Hafler, Jorge R. Oksenberg, David Reich
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Abstract Epidemiological studies have suggested differences in the rate of multiple sclerosis (MS) in individuals of European ancestry compared to African ancestry, motivating genetic scans to identify variants that could contribute to such patterns.
Externí odkaz:
https://doaj.org/article/bbacc879fe7649be855764f1db11ac9a
Autor:
Saef Izzy, Qiong Liu, Zhou Fang, Sevda Lule, Limin Wu, Joon Yong Chung, Aliyah Sarro-Schwartz, Alexander Brown-Whalen, Caroline Perner, Suzanne E. Hickman, David L. Kaplan, Nikolaos A. Patsopoulos, Joseph El Khoury, Michael J. Whalen
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
The neuroinflammatory response to traumatic brain injury (TBI) is critical to both neurotoxicity and neuroprotection, and has been proposed as a potentially modifiable driver of secondary injury in animal and human studies. Attempts to broadly target
Externí odkaz:
https://doaj.org/article/4d51f33285324077b52c79c485bef401
Autor:
Ashley H Beecham, Lilyana Amezcua, Angel Chinea, Clara P Manrique, Lissette Gomez, Andrea Martinez, Gary W Beecham, Nikolaos A Patsopoulos, Tanuja Chitnis, Howard L Weiner, Philip L De Jager, Esteban G Burchard, Brett T Lund, Kathryn C Fitzgerald, Peter A Calabresi, Silvia R Delgado, Jorge R Oksenberg, Jacob L McCauley
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0279132 (2022)
The Major Histocompatibility Complex (MHC) makes the largest genetic contribution to multiple sclerosis (MS) susceptibility, with 32 independent effects across the region explaining 20% of the heritability in European populations. Variation is high a
Externí odkaz:
https://doaj.org/article/2a71d7c0f97a4ee9840c19b2575059f4
Autor:
Sunny Malhotra, Luciana Midaglia, Omar Chuquisana, Nikolaos A. Patsopoulos, Roser Ferrer, Marina Giralt, Nicolas Fissolo, Elia Gil‐Varea, Juan Carlos Triviño, Jan D. Lünemann, Xavier Montalban, Manuel Comabella
Publikováno v:
European Journal of Neurology.
Autor:
Woori, Kim, Nikolaos A, Patsopoulos
Publikováno v:
Seminars in Immunopathology. 44:63-79
Multiple sclerosis (MS) is an inflammatory neurodegenerative disease with genetic predisposition. Over the last decade, genome-wide association studies with increasing sample size led to the discovery of robustly associated genetic variants at an exp
Autor:
Tina Roostaei, Afsana Sabrin, Pia Kivisäkk, Cristin McCabe, Parham Nejad, Daniel Felsky, Hanane Touil, Ioannis S. Vlachos, Daniel Hui, Jennifer Fransson, Nikolaos A. Patsopoulos, Vijay K. Kuchroo, Violetta Zujovic, Howard L. Weiner, Hans-Ulrich Klein, Philip L. De Jager
The polygenic and multi-cellular nature of multiple sclerosis (MS) immunopathology necessitates cell-type-specific molecular studies in order to improve our understanding of the diverse mechanisms underlying immune cell dysfunction in MS. Here, by ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb8ba6ed6f2e8ed4ca84e3c6b64fffac
https://doi.org/10.1101/2022.06.29.498195
https://doi.org/10.1101/2022.06.29.498195
Autor:
Pratiksha I. Thakore, Alexandra Schnell, Maryann Zhao, Linglin Huang, Yu Hou, Elena Christian, Sarah Zaghouani, Chao Wang, Vasundhara Singh, Sai Ma, Venkat Sankar, Samuele Notarbartolo, Jason D. Buenrostro, Federica Sallusto, Nikolaos A. Patsopoulos, Orit Rozenblatt-Rosen, Vijay K. Kuchroo, Aviv Regev
Th17 cells are a heterogenous cell population consisting of non-pathogenic Th17 cells (npTh17) that contribute to tissue homeostasis and pathogenic Th17 cells (pTh17) that are potent mediators of tissue inflammation. To reveal regulatory mechanisms u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d169e14c7d30197d7fc92e62656609e5
https://doi.org/10.1101/2022.02.26.482041
https://doi.org/10.1101/2022.02.26.482041
Autor:
Maxim Imakaev, Nathan O. Stitziel, Benjamin M. Neale, Nikolaos A. Patsopoulos, Sekar Kathiresan, Shamil R. Sunyaev, Sung Chun, Daniel Hui
Publikováno v:
Am J Hum Genet
In complex trait genetics, the ability to predict phenotype from genotype is the ultimate measure of our understanding of genetic architecture underlying the heritability of a trait. A complete understanding of the genetic basis of a trait should all