Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Nikolaos A Patsopoulos"'
Autor:
Ashley H Beecham, Lilyana Amezcua, Angel Chinea, Clara P Manrique, Lissette Gomez, Andrea Martinez, Gary W Beecham, Nikolaos A Patsopoulos, Tanuja Chitnis, Howard L Weiner, Philip L De Jager, Esteban G Burchard, Brett T Lund, Kathryn C Fitzgerald, Peter A Calabresi, Silvia R Delgado, Jorge R Oksenberg, Jacob L McCauley
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0279132 (2022)
The Major Histocompatibility Complex (MHC) makes the largest genetic contribution to multiple sclerosis (MS) susceptibility, with 32 independent effects across the region explaining 20% of the heritability in European populations. Variation is high a
Externí odkaz:
https://doaj.org/article/2a71d7c0f97a4ee9840c19b2575059f4
Autor:
Nikolaos A Patsopoulos, Lisa F Barcellos, Rogier Q Hintzen, Catherine Schaefer, Cornelia M van Duijn, Janelle A Noble, Towfique Raj, IMSGC, ANZgene, Pierre-Antoine Gourraud, Barbara E Stranger, Jorge Oksenberg, Tomas Olsson, Bruce V Taylor, Stephen Sawcer, David A Hafler, Mary Carrington, Philip L De Jager, Paul I W de Bakker
Publikováno v:
PLoS Genetics, Vol 9, Iss 11, p e1003926 (2013)
The major histocompatibility complex (MHC) region is strongly associated with multiple sclerosis (MS) susceptibility. HLA-DRB1*15:01 has the strongest effect, and several other alleles have been reported at different levels of validation. Using SNP d
Externí odkaz:
https://doaj.org/article/6e4e6d6e785f43918ef55c820b6ebf1f
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10888 (2010)
BACKGROUND: Images are important for conveying information, but there is no empirical evidence on whether imaging figures are properly selected and presented in the published medical literature. We therefore evaluated the selection and presentation o
Externí odkaz:
https://doaj.org/article/897f82f05c6443d8bfd9235109580329
Publikováno v:
PLoS ONE, Vol 2, Iss 9, p e841 (2007)
BACKGROUND: Meta-analysis is the systematic and quantitative synthesis of effect sizes and the exploration of their diversity across different studies. Meta-analyses are increasingly applied to synthesize data from genome-wide association (GWA) studi
Externí odkaz:
https://doaj.org/article/b51ed043eb5f462fb83065043a5aed08
Autor:
Sunny Malhotra, Luciana Midaglia, Omar Chuquisana, Nikolaos A. Patsopoulos, Roser Ferrer, Marina Giralt, Nicolas Fissolo, Elia Gil‐Varea, Juan Carlos Triviño, Jan D. Lünemann, Xavier Montalban, Manuel Comabella
Publikováno v:
European Journal of Neurology.
Autor:
Woori, Kim, Nikolaos A, Patsopoulos
Publikováno v:
Seminars in Immunopathology. 44:63-79
Multiple sclerosis (MS) is an inflammatory neurodegenerative disease with genetic predisposition. Over the last decade, genome-wide association studies with increasing sample size led to the discovery of robustly associated genetic variants at an exp
Autor:
Li Dai, Mayuko Uehara, Xiaofei Li, Brenna A. LaBarre, Naima Banouni, Takaharu Ichimura, Melissa M. Lee-Sundlov, Vivek Kasinath, Jade A. Sullivan, Heyu Ni, Francesca Barone, Silvia Giannini, Baharak Bahmani, Peter T. Sage, Nikolaos A. Patsopoulos, George C. Tsokos, Jonathan S. Bromberg, Karin Hoffmeister, Liwei Jiang, Reza Abdi
Publikováno v:
Frontiers in Immunology. 13
Lymph nodes (LNs) are the critical sites of immunity, and the stromal cells of LNs are crucial to their function. Our understanding of the stromal compartment of the LN has deepened recently with the characterization of nontraditional stromal cells.
Autor:
Tina Roostaei, Afsana Sabrin, Pia Kivisäkk, Cristin McCabe, Parham Nejad, Daniel Felsky, Hanane Touil, Ioannis S. Vlachos, Daniel Hui, Jennifer Fransson, Nikolaos A. Patsopoulos, Vijay K. Kuchroo, Violetta Zujovic, Howard L. Weiner, Hans-Ulrich Klein, Philip L. De Jager
The polygenic and multi-cellular nature of multiple sclerosis (MS) immunopathology necessitates cell-type-specific molecular studies in order to improve our understanding of the diverse mechanisms underlying immune cell dysfunction in MS. Here, by ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb8ba6ed6f2e8ed4ca84e3c6b64fffac
https://doi.org/10.1101/2022.06.29.498195
https://doi.org/10.1101/2022.06.29.498195
Autor:
Pratiksha I. Thakore, Alexandra Schnell, Maryann Zhao, Linglin Huang, Yu Hou, Elena Christian, Sarah Zaghouani, Chao Wang, Vasundhara Singh, Sai Ma, Venkat Sankar, Samuele Notarbartolo, Jason D. Buenrostro, Federica Sallusto, Nikolaos A. Patsopoulos, Orit Rozenblatt-Rosen, Vijay K. Kuchroo, Aviv Regev
Th17 cells are a heterogenous cell population consisting of non-pathogenic Th17 cells (npTh17) that contribute to tissue homeostasis and pathogenic Th17 cells (pTh17) that are potent mediators of tissue inflammation. To reveal regulatory mechanisms u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d169e14c7d30197d7fc92e62656609e5
https://doi.org/10.1101/2022.02.26.482041
https://doi.org/10.1101/2022.02.26.482041
Autor:
Maxim Imakaev, Nathan O. Stitziel, Benjamin M. Neale, Nikolaos A. Patsopoulos, Sekar Kathiresan, Shamil R. Sunyaev, Sung Chun, Daniel Hui
Publikováno v:
Am J Hum Genet
In complex trait genetics, the ability to predict phenotype from genotype is the ultimate measure of our understanding of genetic architecture underlying the heritability of a trait. A complete understanding of the genetic basis of a trait should all