Tm7sf2 Disruption Alters Radial Gene Positioning in Mouse Liver Leading to Metabolic Defects and Diabetes Characteristics

Autor: Leonardo Gatticchi, Jose I. de las Heras, Aishwarya Sivakumar, Nikolaj Zuleger, Rita Roberti, Eric C. Schirmer

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Tissue-specific patterns of radial genome organization contribute to genome regulation and can be established by nuclear envelope proteins. Studies in this area often use cancer cell lines, and it is unclear how well such systems recapitulate genome

Externí odkaz: https://doaj.org/article/6d453fadf9dc4d5a966ea2534975fcbc

Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion

Autor: Sylvain Tollis, Andrea Rizzotto, Nhan T. Pham, Sonja Koivukoski, Aishwarya Sivakumar, Steven Shave, Jan Wildenhain, Nikolaj Zuleger, Jeremy T. Keys, Jayne Culley, Yijing Zheng, Jan Lammerding, Neil O. Carragher, Valerie G. Brunton, Leena Latonen, Manfred Auer, Mike Tyers, Eric C. Schirmer

Publikováno v: Tollis, S, Rizzotto, A, Pham, N, Koivukoski, S, Sivakumar, A, Shave, S, Wildenhain, J, Zuleger, N, Keys, J T, Culley, J, Zheng, Y, Lammerding, J, Carragher, N O, Brunton, V G, Latonen, L, Auer, M, Tyers, M & Schirmer, E C 2022, ' Chemical interrogation of nuclear size identifies compounds with cancer cell line specific effects on migration and invasion ', Acs chemical biology, vol. 17, no. 3, pp. 680-700 . https://doi.org/10.1021/acschembio.2c00004

Background: Lower survival rates for many cancer types correlate with changes in nuclear size/scaling in a tumor-type/tissue-specific manner. Hypothesizing that such changes might confer an advantage to tumor cells, we aimed at the identification of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff85aa3d38df3238eedb73ff6ebe3d96
https://doi.org/10.1021/acschembio.2c00004

Chemical-Genetic Interrogation of Nuclear Size Control Reveals Cancer-Specific Effects on Cell Migration and Invasion

Autor: Nhan T. Pham, Sarah Zheng, Nikolaj Zuleger, Andrea Rizzotto, Eric C. Schirmer, Manfred Auer, Mike Tyers, Valerie G. Brunton, Jan Lammerding, Jeremy Keys, Neil O. Carragher, Sylvain Tollis, Dzmitry G. Batrakou, Jayne Culley, Jan Wildenhain

Lower survival rates for many cancer types correlate with increases or decreases in nuclear size/scaling in a tumor-type/tissue-specific manner. Postulating that nuclear size changes confer a fitness advantage on tumor cells, we screened for FDA/EMA-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7369775b9e92d9011ba0a366cfb96f94

The nuclear envelope proteome differs notably between tissues

Autor: Nikolaj Zuleger, Nadia Korfali, Jose I. de las Heras, Eric C. Schirmer, Laurence Florens, Poonam Malik, Vlastimil Srsen, Selene K. Swanson, Gavin S. Wilkie, Alastair R.W. Kerr, Dzmitry G. Batrakou

Publikováno v: Korfali, N, Wilkie, G S, Swanson, S K, Srsen, V, de las Heras, J, Batrakou, D G, Malik, P, Zuleger, N, Kerr, A, Florens, L & Schirmer, E 2012, ' The nuclear envelope proteome differs notably between tissues ', Nucleus, vol. 3, no. 6, pp. 552-564 . https://doi.org/10.4161/nucl.22257
Nucleus

One hypothesis to explain how mutations in the same nuclear envelope proteins yield pathologies focused in distinct tissues is that as yet unidentified tissue-specific partners mediate the disease pathologies. The nuclear envelope proteome was recent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb1f0fc67721ae7c63d6fe7a0e284a8
https://doi.org/10.4161/nucl.22257

The nuclear envelope as a chromatin organizer

Autor: Eric C. Schirmer, Nikolaj Zuleger, Michael I. Robson

Publikováno v: Zuleger, N, Robson, M I & Schirmer, E C 2011, ' The nuclear envelope as a chromatin organizer ', Nucleus, vol. 2, no. 5, pp. 339-49 . https://doi.org/10.4161/nucl.2.5.17846

In the past 15 years our perception of nuclear envelope function has evolved perhaps nearly as much as the nuclear envelope itself evolved in the last 3 billion years. Historically viewed as little more than a diffusion barrier between the cytoplasm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de02a735a24c025352a018baa473bb2c
https://doi.org/10.4161/nucl.2.5.17846