Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Nikolaj Speth"'
1
Akademický článek
Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson’s Disease
Autor: Nakul Ravi Raval, Frederik Gudmundsen, Morten Juhl, Ida Vang Andersen, Nikolaj Speth, Annesofie Videbæk, Ida Nymann Petersen, Jens D. Mikkelsen, Patrick MacDonald Fisher, Matthias Manfred Herth, Pontus Plavén-Sigray, Gitte Moos Knudsen, Mikael Palner
Publikováno v: Frontiers in Synaptic Neuroscience, Vol 13 (2021)
Parkinson’s disease (PD) is caused by progressive neurodegeneration and characterised by motor dysfunction. Neurodegeneration of dopaminergic neurons also causes aberrations within the cortico-striato-thalamo-cortical (CSTC) circuit, which has been
Externí odkaz: https://doaj.org/article/208306ca073a449cbd98aebf8b4617c7
Zobrazit plný text záznamu
3
Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson’s Disease
Autor: Matthias M. Herth, Ida Nymann Petersen, Nakul Ravi Raval, Mikael Palner, Frederik Gudmundsen, Patrick M. Fisher, Pontus Plavén-Sigray, Gitte M. Knudsen, Nikolaj Speth, Annesofie Videbæk, Morten Juhl, Ida Vang Andersen, Jens D. Mikkelsen
Publikováno v: Frontiers in Synaptic Neuroscience, Vol 13 (2021)
Raval, N R, Gudmundsen, F, Juhl, M, Andersen, I V, Speth, N, Videbæk, A, Petersen, I N, Mikkelsen, J D, Fisher, P M D, Herth, M M, Plavén-Sigray, P, Knudsen, G M & Palner, M 2021, ' Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson’s Disease ', Frontiers in Synaptic Neuroscience, vol. 13, 715811 . https://doi.org/10.3389/fnsyn.2021.715811
Frontiers in Synaptic Neuroscience
Parkinson’s disease (PD) is caused by progressive neurodegeneration and characterised by motor dysfunction. Neurodegeneration of dopaminergic neurons also causes aberrations within the cortico-striato-thalamo-cortical (CSTC) circuit, which has been
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216c52516384ff3a726fb0224014a675
https://www.frontiersin.org/articles/10.3389/fnsyn.2021.715811/full
Zobrazit plný text záznamu
4
Desorption Electrospray Ionization Mass Spectrometry Imaging of Cimbi-36, a 5-HT2A Receptor Agonist, with Direct Comparison to Autoradiography and Positron Emission Tomography
Autor: Mengfei Xiong, Matthias M. Herth, Nikolaj Speth, Mikael Palner, Sophie Chakroun Jacobsen, Christian Janfelt, Jesper L. Kristensen
Publikováno v: Jacobsen, S C, Speth, N R, Xiong, M, Herth, M M, Kristensen, J L, Palner, M & Janfelt, C 2021, ' Desorption Electrospray Ionization Mass Spectrometry Imaging of Cimbi-36, a 5-HT 2A Receptor Agonist, with Direct Comparison to Autoradiography and Positron Emission Tomography ', Molecular Imaging and Biology, vol. 23, pp. 676–685 . https://doi.org/10.1007/s11307-021-01592-2
Purpose The study demonstrates the use of Desorption Electrospray Ionization mass spectrometry imaging (DESI-MSI) for imaging of the PET tracer compound Cimbi-36 in brain tissue and compares imaging by DESI-MSI to imaging by autoradiography and PET.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49f3f2132328d077a8a582cf93c8941
https://curis.ku.dk/ws/files/336199737/DESI_MSI_RevisedManuscript.pdf
Zobrazit plný text záznamu
5
Blocking of efflux transporters in rats improves translational validation of brain radioligands
Autor: Gitte M. Knudsen, Siv Thorlund Peitersen, Mengfei Xiong, Matthias M. Herth, Lene Lundgaard Donovan, Nikolaj Speth, Andreas Kjaer, Arafat Nasser, Fraser G. Edgar, Ida Vang Andersen, Hanne D. Hansen, Mikael Palner, Vladimir Shalgunov, Simone L. Baerentzen, Nakul Ravi Raval, Stina Syvänen, Elina T. L’Estrade
Publikováno v: EJNMMI Research, Vol 10, Iss 1, Pp 1-11 (2020)
EJNMMI Research
Shalgunov, V, Xiong, M, L’Estrade, E T, Raval, N R, Andersen, I V, Edgar, F G, Speth, N R, Baerentzen, S L, Hansen, H D, Donovan, L L, Nasser, A, Peitersen, S T, Kjaer, A, Knudsen, G M, Syvänen, S, Palner, M & Herth, M M 2020, ' Blocking of efflux transporters in rats improves translational validation of brain radioligands ', EJNMMI Research, vol. 10, no. 1, 124 . https://doi.org/10.1186/s13550-020-00718-x
Background Positron emission tomography (PET) is a molecular imaging technique that can be used to investigate the in vivo pharmacology of drugs. Initial preclinical evaluation of PET tracers is often conducted in rodents due to the accessibility of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b31dd2bfd3f9e918d2dc8084a6194f
https://pubmed.ncbi.nlm.nih.gov/33074370
Zobrazit plný text záznamu
6
The selective 5-HT2A receptor agonist 25CN-NBOH: Structure-activity relationship, in vivo pharmacology, and in vitro and ex vivo binding characteristics of [3H]25CN-NBOH
Autor: Emil Märcher-Rørsted, Anna U. Odland, Adam L. Halberstadt, Nikolaj Speth, Mikael Palner, Jesper L. Kristensen, Jesper T. Andreasen, Hans Bräuner-Osborne, Muhammad Chatha, Martin Hansen, Gudrun Liebscher, Anders A. Jensen
Publikováno v: Biochemical Pharmacology. 177:113979
The remarkable effects exhibited by classical psychedelics in recent clinical trials have spawned considerable interest in 5-HT2A receptor (5-HT2AR) activation as a treatment strategy for several psychiatric/cognitive disorders. In this study we have
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f211470c6e9d4c0798e04e40a94e228
https://doi.org/10.1016/j.bcp.2020.113979
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje