Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Nikolaj L. Villadsen"'
Autor:
David Olagnier, Aske M. Brandtoft, Camilla Gunderstofte, Nikolaj L. Villadsen, Christian Krapp, Anne L. Thielke, Anders Laustsen, Suraj Peri, Anne Louise Hansen, Lene Bonefeld, Jacob Thyrsted, Victor Bruun, Marie B. Iversen, Lin Lin, Virginia M. Artegoitia, Chenhe Su, Long Yang, Rongtuan Lin, Siddharth Balachandran, Yonglun Luo, Mette Nyegaard, Bernadette Marrero, Raphaela Goldbach-Mansky, Mona Motwani, Dylan G. Ryan, Katherine A. Fitzgerald, Luke A. O’Neill, Anne K. Hollensen, Christian K. Damgaard, Frank v. de Paoli, Hanne C. Bertram, Martin R. Jakobsen, Thomas B. Poulsen, Christian K. Holm
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Understanding how regulators of inflammation affect nucleic acid sensing is important for targeting research against inflammatory diseases and conditions. Here, the authors identify Nrf2 as an important negative regulator of STING and suggest a link
Externí odkaz:
https://doaj.org/article/5fc54bf6fbd8427c94401b47231854b6
Publikováno v:
Wørmer, G J, Villadsen, N L, Nørby, P & Poulsen, T B 2021, ' Concise Asymmetric Syntheses of Streptazone A and Abikoviromycin** ', Angewandte Chemie-International Edition, vol. 60, no. 19, pp. 10521-10525 . https://doi.org/10.1002/anie.202101439
Wørmer, G J, Villadsen, N L, Poulsen, T & Nørby, P 2021, ' Concise asymmetric syntheses of streptazone A and abikoviromycin ', 21st Tetrahedron Symposium, 21/06/2021-24/06/2021 .
Aarhus University
Wørmer, G J, Villadsen, N L, Poulsen, T & Nørby, P 2021, ' Concise asymmetric syntheses of streptazone A and abikoviromycin ', 21st Tetrahedron Symposium, 21/06/2021-24/06/2021 .
Aarhus University
Streptazone A and abikoviromycin are related alkaloids that both feature an unusual arrangement of reactive functionalities within an underlying compact tricyclic ring system. Here, we report a highly concise asymmetric synthesis of both natural prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::004b845ce21c01d32eef290ca7b02a8a
https://doi.org/10.1002/anie.202101439
https://doi.org/10.1002/anie.202101439
Publikováno v:
Angewandte Chemie International Edition. 60:10433-10433
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::743c2f4779f5dab62307861f70b68ee2
https://doi.org/10.1002/anie.202103581
https://doi.org/10.1002/anie.202103581
Publikováno v:
Angewandte Chemie. 133:10525-10525
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::531ddd6f1bc6b7eccdb853bd0cfab356
https://doi.org/10.1002/ange.202103581
https://doi.org/10.1002/ange.202103581
Publikováno v:
Tsakos, M, Jacobsen, K M, Yu, W, Villadsen, N L & Poulsen, T 2016, ' The Rakicidin Family of Anticancer Natural Products : Synthetic Strategies towards a New Class of Hypoxia-Selective Cytotoxins ', SYNLETT: Accounts and Rapid Communications in Chemical Synthesis, vol. 27, no. 13, pp. 1898-1906 . https://doi.org/10.1055/s-0035-1561465
Rakicidin A is a prominent member of a small class of macrocyclic lipodepsipeptide natural products that contain an electrophilic 4-amido-2,4-pentadienoate (APD) functionality. Rakicidin A displays selective growth inhibitory activity against hypoxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6073c6a463790c5569571b33469a1de9
https://doi.org/10.1055/s-0035-1561465
https://doi.org/10.1055/s-0035-1561465
Autor:
Nikolaj L. Villadsen, Katrine H. Jørgensen, Bente Krogh Hansen, Esben B. Svenningsen, Thomas B. Poulsen, Thomas Tørring
Publikováno v:
Villadsen, N L, Hansen, B K, Svenningsen, E B, Jørgensen, K H, Tørring, T & Poulsen, T B 2018, ' Stendomycin and Pantomycin Are Identical Natural Products : Preparation of a Functionalized Bioactive Analogue ', Journal of Organic Chemistry, vol. 83, no. 13, pp. 7303-7308 . https://doi.org/10.1021/acs.joc.8b00553
The natural products pantomycin and stendomycin were both reported as antimicrobial agents. We demonstrate by gene cluster analysis, LC-MS analysis, and isolation that these polypeptides are identical, and we identify previously unknown congeners. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d401a49e28afba5bb8015a6e3de689f3
https://pure.au.dk/portal/da/publications/stendomycin-and-pantomycin-are-identical-natural-products(79de6cc0-5af5-4286-8c4d-b0a9bc41437c).html
https://pure.au.dk/portal/da/publications/stendomycin-and-pantomycin-are-identical-natural-products(79de6cc0-5af5-4286-8c4d-b0a9bc41437c).html
Autor:
Rikke Nielsen, Kristian M. Jacobsen, Morten Muhlig Nielsen, Jakob Skou Pedersen, Carsten Scavenius, Camilla Bak Nielsen, Thomas B. Poulsen, Peter Bross, Nikolaj L. Villadsen, Erik Ilsø Christensen, Jens Overgaard, Jan J. Enghild, Trine Salomón, Michael R. Horsman, Christian Sibbersen, Paula Fernandez Guerra, Jørgen Frøkiær, Thomas Tørring, Mogens Johannsen, Morten Busk, Michail Tsakos
Publikováno v:
Jacobsen, K M, Villadsen, N L, Tørring, T, Nielsen, C B, Salomón, T, Nielsen, M M, Tsakos, M, Sibbersen, C, Scavenius, C, Nielsen, R, Christensen, E I, Guerra, P F, Bross, P, Pedersen, J S, Enghild, J J, Johannsen, M, Frøkiær, J, Overgaard, J, Horsman, M R, Busk, M & Poulsen, T B 2018, ' APD-Containing Cyclolipodepsipeptides Target Mitochondrial Function in Hypoxic Cancer Cells ', Cell Chemical Biology, vol. 25, no. 11, pp. 1337-1349.e12 . https://doi.org/10.1016/j.chembiol.2018.07.010
The natural product family of macrocyclic lipodepsipeptides containing the 4-amido-2,4-pentadienoate functionality possesses intriguing cytotoxic selectivity toward hypoxic cancer cells. These subpopulations of cancer cells display increased metastat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::704e820d6477fd45a78aaa387061c19f
https://pubmed.ncbi.nlm.nih.gov/30445051
https://pubmed.ncbi.nlm.nih.gov/30445051
Autor:
Katherine A. Fitzgerald, Bernadette Marrero, Siddharth Balachandran, Dylan G. Ryan, David Olagnier, Mona Motwani, Frank Vincenzo de Paoli, Marie B. Iversen, Yonglun Luo, Camilla Gunderstofte, Chenhe Su, Martin R. Jakobsen, Jacob Thyrsted, Hanne Christine Bertram, Aske M Brandtoft, Nikolaj L. Villadsen, Anne Kruse Hollensen, Christian K. Holm, Suraj Peri, Anne Louise Hansen, Christian Krapp, Victor Bruun, Long Yang, Virginia M. Artegoitia, Mette Nyegaard, Lin Lin, Anders Laustsen, Anne L. Thielke, Luke A. J. O'Neill, Thomas B. Poulsen, Christian Kroun Damgaard, Rongtuan Lin, Lene Bonefeld, Raphaela Goldbach-Mansky
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Olagnier, D, Brandtoft, A M, Gunderstofte, C, Villadsen, N L, Krapp, C, Thielke, A L, Laustsen, A, Peri, S, Hansen, A L, Bonefeld, L, Thyrsted, J, Bruun, V, Iversen, M B, Lin, L, Artegoitia, V M, Su, C, Yang, L, Lin, R, Balachandran, S, Luo, Y, Nyegaard, M, Marrero, B, Goldbach-Mansky, R, Motwani, M, Ryan, D G, Fitzgerald, K A, O'Neill, L A, Hollensen, A K, Damgaard, C K, de Paoli, F V, Bertram, H C, Jakobsen, M R, Poulsen, T B & Holm, C K 2018, ' Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming ', Nature Communications, vol. 9, no. 1, 3506 . https://doi.org/10.1038/s41467-018-05861-7
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Olagnier, D, Brandtoft, A M, Gunderstofte, C, Villadsen, N L, Krapp, C, Thielke, A L, Laustsen, A, Peri, S, Hansen, A L, Bonefeld, L, Thyrsted, J, Bruun, V, Iversen, M B, Lin, L, Artegoitia, V M, Su, C, Yang, L, Lin, R, Balachandran, S, Luo, Y, Nyegaard, M, Marrero, B, Goldbach-Mansky, R, Motwani, M, Ryan, D G, Fitzgerald, K A, O'Neill, L A, Hollensen, A K, Damgaard, C K, de Paoli, F V, Bertram, H C, Jakobsen, M R, Poulsen, T B & Holm, C K 2018, ' Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming ', Nature Communications, vol. 9, no. 1, 3506 . https://doi.org/10.1038/s41467-018-05861-7
The transcription factor Nrf2 is a critical regulator of inflammatory responses. If and how Nrf2 also affects cytosolic nucleic acid sensing is currently unknown. Here we identify Nrf2 as an important negative regulator of STING and suggest a link be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5370550ac68fa6f98e5aeab0601064f0
https://pubmed.ncbi.nlm.nih.gov/30158636
https://pubmed.ncbi.nlm.nih.gov/30158636
Publikováno v:
Tsakos, M, Schaffert, E S, Clement, L L, Villadsen, N L & Poulsen, T 2015, ' Ester Coupling Reactions – an Enduring Challenge in the Chemical Synthesis of Bioactive Natural Products ', Natural Product Reports, vol. 32, no. 4, pp. 605-632 . https://doi.org/10.1039/c4np00106k
Covering: up to 2014 In this review we investigate the use of complex ester fragment couplings within natural product total synthesis campaigns. We first outline the different biosynthetic and chemical strategies for performing complex ester coupling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a7ea2315ed487b80e289b09b6e1ba4
https://doi.org/10.1039/c4np00106k
https://doi.org/10.1039/c4np00106k
Autor:
Bjørn Christiansen, Thomas Tørring, Nikolaj L. Villadsen, Ulrik B. Keiding, Thomas B. Poulsen, Kristian M. Jacobsen, Frank Jensen, Mogens Johannsen, Morten Bjerring, Thomas Vosegaard, Esben Thybo Weibel
Publikováno v:
Villadsen, N L, Jacobsen, K M, Keiding, U, Weibel, E T, Christiansen, B, Vosegaard, T, Bjerring, M, Jensen, F, Johannsen, M, Tørring, T & Poulsen, T 2017, ' Synthesis of ent-BE-43547A 1 reveals a potent hypoxia-selective anticancer agent and uncovers the biosynthetic origin of the APD-CLD natural products ', Nature Chemistry, vol. 9, pp. 264-272 . https://doi.org/10.1038/nchem.2657
Tumour hypoxia is speculated to be a key driver of therapeutic resistance and metastatic dissemination. Consequently, the discovery of new potent agents that selectively target the hypoxic cell population may reveal new and untapped antitumour mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08225fb1f72b9bd89e2d5d3e3a48dae7
https://pure.au.dk/portal/da/publications/synthesis-of-entbe43547a1-reveals-a-potent-hypoxiaselective-anticancer-agent-and-uncovers-the-biosynthetic-origin-of-the-apdcld-natural-products(75186ab1-d5ae-40f2-90c6-b770edc696b7).html
https://pure.au.dk/portal/da/publications/synthesis-of-entbe43547a1-reveals-a-potent-hypoxiaselective-anticancer-agent-and-uncovers-the-biosynthetic-origin-of-the-apdcld-natural-products(75186ab1-d5ae-40f2-90c6-b770edc696b7).html