Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Nikolaj Kulahin"'
Autor:
Fan Wu, Linlin Yang, Kaini Hang, Mette Laursen, Lijie Wu, Gye Won Han, Qiansheng Ren, Nikolaj Kulahin Roed, Guangyao Lin, Michael A. Hanson, Hualiang Jiang, Ming-Wei Wang, Steffen Reedtz-Runge, Gaojie Song, Raymond C. Stevens
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Glucagon-like peptide-1 receptor (GLP-1R) plays an important role in glucose homeostasis and treatment of type 2 diabetes. Here authors report the peptide-free crystal structure of human GLP-1R in an inactive state which reveals a unique closed confo
Externí odkaz:
https://doaj.org/article/3203b4bbea3845c690168fa0775d64d9
Autor:
Nikolaj Kulahin Roed, Cristina M. Viola, Ole Kristensen, Gerd Schluckebier, Mathias Norrman, Waseem Sajid, John D. Wade, Asser Sloth Andersen, Claus Kristensen, Timothy R. Ganderton, Johan P. Turkenburg, Pierre De Meyts, Andrzej M. Brzozowski
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Insulin-like polypeptide binding proteins (IBPs) from insects can bind diverse insulin-like proteins (ILPs) including human insulin and IGFs. Here, the authors present structures of a Drosophila IBP in its free and ILP-bound forms, providing insights
Externí odkaz:
https://doaj.org/article/ab49da7df68b46db823e2dfac264e41c
Autor:
Kim Krighaar Rasmussen, Maria Hansen Falkesgaard, Malene Winther, Nikolaj Kulahin Roed, Christine Louise Quistgaard, Marie Nygaard Teisen, Sofie Marie Edslev, David Leander Petersen, Ali Aljubouri, Claus Christensen, Peter Waaben Thulstrup, Leila Lo Leggio, Kaare Teilum, Peter Schledermann Walmod
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract NCAM1 and NCAM2 have ectodomains consisting of 5 Ig domains followed by 2 membrane-proximal FnIII domains. In this study we investigate and compare the structures and functions of these FnIII domains. The NCAM1 and -2 FnIII2 domains both con
Externí odkaz:
https://doaj.org/article/0d20311e21774d27b2f15fe4f66a9f48
Autor:
Christina Pedersen, Trine Porsgaard, Maria Thomsen, Mette Marie Rosenkilde, Nikolaj Kulahin Roed
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194468 (2018)
Insulin is a vital part of diabetes treatment, whereas glucagon is primarily used to treat insulin-induced hypoglycemia. However, glucagon is suggested to have a central role in the regulation of body weight, which would be beneficial for diabetic pa
Externí odkaz:
https://doaj.org/article/40a5ce0aefe944508eeea8fafa7e9ca3
Autor:
Hualiang Jiang, Raymond C. Stevens, Qiansheng Ren, Gye Won Han, Ming-Wei Wang, Nikolaj Kulahin Roed, Steffen Reedtz-Runge, Fan Wu, Michael A. Hanson, Guangyao Lin, Kaini Hang, Gaojie Song, Lijie Wu, Linlin Yang, Mette Laursen
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Glucagon-like peptide-1 receptor (GLP-1R) is a class B G protein-coupled receptor that plays an important role in glucose homeostasis and treatment of type 2 diabetes. Structures of full-length class B receptors were determined in complex with their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c630982bc7e23cf50ee80706fe2d0e
https://doi.org/10.1038/s41467-020-14934-5
https://doi.org/10.1038/s41467-020-14934-5
Autor:
Claus Christensen, Kaare Teilum, Peter S. Walmod, Marie N. Teisen, K.K. Rasmussen, Sofie Marie Edslev, Leila Lo Leggio, Ali Aljubouri, Christine Louise Quistgaard, Peter W. Thulstrup, Malene Winther, David L. Petersen, Maria Hansen Falkesgaard, Nikolaj Kulahin Roed
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
'Scientific Reports ', vol: 8, pages: 8957-1-8957-13 (2018)
Rasmussen, K K, Falkesgaard, M H, Winther, M, Roed, N K, Quistgaard, C L A, Teisen, M N, Edslev, S M, Petersen, D L, Aljubouri, A, Christensen, C, Thulstrup, P W, Lo Leggio, L, Teilum, K & Walmod, P S 2018, ' NCAM2 Fibronectin type-III domains form a rigid structure that binds and activates the Fibroblast Growth Factor Receptor ', Scientific Reports, vol. 8, 8957 . https://doi.org/10.1038/s41598-018-27089-7
'Scientific Reports ', vol: 8, pages: 8957-1-8957-13 (2018)
Rasmussen, K K, Falkesgaard, M H, Winther, M, Roed, N K, Quistgaard, C L A, Teisen, M N, Edslev, S M, Petersen, D L, Aljubouri, A, Christensen, C, Thulstrup, P W, Lo Leggio, L, Teilum, K & Walmod, P S 2018, ' NCAM2 Fibronectin type-III domains form a rigid structure that binds and activates the Fibroblast Growth Factor Receptor ', Scientific Reports, vol. 8, 8957 . https://doi.org/10.1038/s41598-018-27089-7
NCAM1 and NCAM2 have ectodomains consisting of 5 Ig domains followed by 2 membrane-proximal FnIII domains. In this study we investigate and compare the structures and functions of these FnIII domains. The NCAM1 and -2 FnIII2 domains both contain a Wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d652906ac5bf61f65633e3aef5004e8
https://doaj.org/article/0d20311e21774d27b2f15fe4f66a9f48
https://doaj.org/article/0d20311e21774d27b2f15fe4f66a9f48
Akademický článek
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Autor:
Mette M. Rosenkilde, Maria Thomsen, Nikolaj Kulahin Roed, Christina Pedersen, Trine Porsgaard
Publikováno v:
Pedersen, C, Porsgaard, T, Thomsen, M, Rosenkilde, M M & Roed, N K 2018, ' Sustained effect of glucagon on body weight and blood glucose : Assessed by continuous glucose monitoring in diabetic rats ', PLoS ONE, vol. 13, no. 3, .0194468 . https://doi.org/10.1371/journal.pone.0194468
PLoS ONE
PLoS ONE, Vol 13, Iss 3, p e0194468 (2018)
PLoS ONE
PLoS ONE, Vol 13, Iss 3, p e0194468 (2018)
Insulin is a vital part of diabetes treatment, whereas glucagon is primarily used to treat insulin-induced hypoglycemia. However, glucagon is suggested to have a central role in the regulation of body weight, which would be beneficial for diabetic pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67fbe6eedf48a4e8cddd44e4bf240350
https://curis.ku.dk/ws/files/215925429/journal.pone.0194468.pdf
https://curis.ku.dk/ws/files/215925429/journal.pone.0194468.pdf
Autor:
Nikolaj Kulahin Roed, Mette M. Rosenkilde, Stephan D. Bouman, Trine Porsgaard, Christina Pedersen
Publikováno v:
Pedersen, C, Bouman, S D, Porsgaard, T, Rosenkilde, M M & Roed, N K 2018, ' Dual treatment with a fixed ratio of glucagon and insulin increases the therapeutic window of insulin in diabetic rats ', Physiological Reports, vol. 6, no. 6, e13657 . https://doi.org/10.14814/phy2.13657
Physiological Reports
Physiological Reports
The current available insulin therapies decrease blood glucose but are associated with the risk of developing hypoglycemia. Glucagon is a counter regulatory hormone and we hypothesize that a fixed ratio of insulin and a long‐acting glucagon‐analo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8223881da8a383b583974c3dbde50de3
https://curis.ku.dk/ws/files/215786351/Pedersen_et_al_2018_Physiological_Reports.pdf
https://curis.ku.dk/ws/files/215786351/Pedersen_et_al_2018_Physiological_Reports.pdf
Autor:
Nikolaj Kulahin, Rasmus Jorgensen, Christina Lyngsø, Jakob Lerche Hansen, Samra Joke Sanni, Steen Gammeltoft
Publikováno v:
Journal of receptor and signal transduction research. 37(6)
The angiotensin AT1 receptor is a seven transmembrane (7TM) receptor, which mediates the regulation of blood pressure. Activation of angiotensin AT1 receptor may lead to impaired insulin signaling indicating crosstalk between angiotensin AT1 receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b43492195d5370c3a6b7237572a37e2
https://pubmed.ncbi.nlm.nih.gov/28854843
https://pubmed.ncbi.nlm.nih.gov/28854843