Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Nikolai V. Kaverin"'
Autor:
Nikolai V. Kaverin, CrimeaSpecGeology
Publikováno v:
Vestnik SSUGT (Siberian State University of Geosystems and Technologies). 24:130-140
Autor:
Irina A. Rudneva, Nicolai V. Bovin, N. A. Ilyushina, Anna V. Ignatieva, Nikolai V. Kaverin, Shilov Aa, Tatiana A. Timofeeva
Publikováno v:
Virus Research. 210:81-89
We believe that the monitoring of pleiotropic effects of the hemagglutinin (HA) mutations found in H5 escape mutants is essential for accurate prediction of mutants with pandemic potential. In the present study, we assessed multiple characteristics o
Autor:
E. A. Mukasheva, Boris I. Timofeev, Elena Burtseva, Tatiana A. Timofeeva, Irina A. Rudneva, Anna V. Ignatieva, Shilov Aa, Nikolai V. Kaverin
Publikováno v:
Virus research. 251
In the present study we assessed pleiotropic characteristics of the antibody-selected mutations. We investigated pH optimum of fusion, temperatures of HA heat inactivation, in vivo and in vitro replication kinetics, and connectivity with panel of ser
Autor:
Klimova Rr, Natalia A. Ilyushina, Irina A. Rudneva, O. V. Masalova, Nikolai V. Kaverin, Alla A. Kushch, Shilov Aa, Anna V. Ignatieva, Tatiana A. Timofeeva
Publikováno v:
Molecular Biology. 49:303-311
Changes associated with the resistance to physical and chemical factors in the hemagglutinin (HA) of influenza A viruses may play an important role in the selection of different influenza variants during circulation in nature. Here, we studied the es
Autor:
Alla A. Kushch, Irina A. Rudneva, Klimova Rr, Tatiana A. Timofeeva, L. V. Mochalova, Nikolai V. Kaverin, Nicolai V. Bovin, Anna V. Ignatieva, Shilov Aa, O. V. Masalova
Publikováno v:
Virus Research. 166:61-67
A panel of 6 neutralizing monoclonal antibodies (MAbs) raised against A/Moscow/IIV01/2009 (H1N1) virus isolated during the 2009 pandemic was used for the selection of 26 escape mutants. The mutants were characterized in immune cross-reactions with th
Autor:
Klimova Rr, O. V. Masalova, Anna V. Ignatieva, Petr S. Krylov, Irina A. Rudneva, Tatiana A. Timofeeva, Alla A. Kushch, Shilov Aa, Nikolai V. Kaverin
Publikováno v:
Viral Immunology. 23:181-187
The highly pathogenic avian influenza H5N1 viruses have become widespread and evolved into several clades. In our previous studies, the antigenic sites of the H5 hemagglutinin (HA) were characterized by selection and sequencing of escape mutants. In
Autor:
Tatiana A. Timofeeva, Irina A. Rudneva, P. S. Krylov, A. M. Khalenkov, Nikolai V. Kaverin, Robert G. Webster, Natalia A. Ilyushina
Publikováno v:
Archives of Virology. 155:107-110
In our earlier studies, we showed that an escape mutant of mouse-adapted H9N2 influenza virus carrying a T198N amino acid change in heamagglutinin (HA) has a lowered virulence for mice. The readaptation of this mutant to mice was associated with N198
Autor:
Piotr S. Krylov, Elena A. Govorkova, Robert G. Webster, Konstantin S. Kochergin-Nikitsky, Tatyana A. Timofeeva, Nikolai V. Kaverin, Irina A. Rudneva, Shilov Aa
Publikováno v:
Journal of Virology. 81:12911-12917
We mapped the hemagglutinin (HA) antigenic epitopes of a highly pathogenic H5N1 influenza virus on the three-dimensional HA structure by characterizing escape mutants of a recombinant virus containing A/Vietnam/1203/04 (H5N1) ΔHA and neuraminidase g
Autor:
Robert G. Webster, Irina A. Rudneva, Nikolai V. Kaverin, Tatiana A. Timofeeva, Natalia A. Ilyushina
Publikováno v:
Journal of General Virology. 86:2831-2838
Antigenic mapping of the haemagglutinin (HA) molecule of H5 and H9 influenza viruses by selecting escape mutants with monoclonal anti-HA antibodies and subjecting the selected viruses to immunological analysis and sequencing has previously been perfo
Autor:
Natalia A. Ilyushina, Irina A. Rudneva, Robert G. Webster, Nikolai V. Kaverin, Varich Nl, Aleksandr S. Lipatov
Publikováno v:
International Congress Series. 1263:682-686
Background : In two decades, from 1981 to 2001, H3, H1, and H2 (and, to limited extent, H5) subtypes of influenza A virus hemagglutinin (HA) were analyzed with respect to the location and structure of antigenic epitopes. For H5 HA, the location of th