Výsledky vyhledávání - "Nikolai V. Gnuchev"

Прямой молекулярный фишинг цинкзависимых белковых партнеров бета-амилоида 1–16 с 'Тайваньской' (D7H) мутацией и с фосфорилированным остатком Ser8

Autor: P V Ershov, Nikolai V. Gnuchev, Alexander A. Makarov, Vladimir A. Mitkevich, E O Yablokov, Yu. V. Mezentsev, Andrew Ivanov, L A Kaluzgskiy, Sergey A. Kozin

Publikováno v: Молекулярная биология. 54:1029-1036

We previously showed that the metal-binding domain 1-16 of intact amyloid-beta (Aβ) is involved in interactions with a number of proteins from the cytosolic fraction of SK-N-SH human neuroblastoma cells in a zinc-dependent manner only. It is known t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::167dafba351cd21ae2cc535a96fcb11e
https://doi.org/10.31857/s0026898420060038

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Overexpression of microRNAs miR-9, -98, and -199 Correlates with the Downregulation of HK2 Expression in Colorectal Cancer

Autor: George S. Krasnov, A V Snezhkina, Kirill M. Nyushko, Nataliya V. Melnikova, M. M. Belyakov, Nikolai V. Gnuchev, M. S. Fedorova, Svetlana Zhikrivetskaya, Boris Alekseev, I. Y. Karpova, D. V. Sidorov, Anna V. Kudryavtseva

Publikováno v: Molecular Biology. 52:190-199

Glycolysis activation is one of the main features of energy metabolism in cancer cells that is associated with the increase in glycolytic enzyme synthesis, primarily, hexokinases (HKs), in many types of tumors. Conversely, in colorectal cancer (CRC)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34e77bca1d52ab1ddfd7298ec9235663
https://doi.org/10.1134/s0026893318020140

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The Heat Shock-binding Protein (HspBP1) Protects Cells against the Cytotoxic Action of the Tag7-Hsp70 Complex

Autor: Vince Guerriero, Deborah A. Raynes, E. A. Romanova, Olga D. Kabanova, Nikolai V. Gnuchev, Georgii P. Georgiev, Denis V. Yashin, Alexsander G. Tonevitskii, Dukhanina Ea, Tamara I. Lukyanova, Lidia P. Sashchenko

Publikováno v: Journal of Biological Chemistry. 286:10258-10264

Heat shock-binding protein HspBP1 is a member of the Hsp70 co-chaperone family. The interaction between HspBP1 and the ATPase domain of the major heat shock protein Hsp70 up-regulates nucleotide exchange and reduces the affinity between Hsp70 and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d34d9bf3af80d090291d0e0b7a6e6c9d
https://doi.org/10.1074/jbc.m110.163436

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Cytotoxic T lymphocytes carrying a pattern recognition protein Tag7 can detect evasive, HLA-negative but Hsp70-exposing tumor cells, thereby ensuring FasL/Fas-mediated contact killing

Autor: Lidia P. Sashchenko, Olga D. Kabanova, Georgii P. Georgiev, E. A. Romanova, Alexander V. Galkin, Dukhanina Ea, Yury V. Shatalov, Nikolai V. Gnuchev, S. V. Khaidukov, Tamara I. Lukyanova, Denis V. Yashin

Publikováno v: Blood. 110:1997-2004

Within the broad problem of host immune surveillance versus tumor immune evasion, a most intriguing question is how the cellular immunity can cope with cancerous cells that have gotten rid of the classical antigen-presenting machinery. One such optio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae897af8b1b1f365f83f456a0dc416e
https://doi.org/10.1182/blood-2006-12-064444

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Tag7 (PGLYRP1) in Complex with Hsp70 Induces Alternative Cytotoxic Processes in Tumor Cells via TNFR1 Receptor

Autor: Dukhanina Ea, Alexander G. Tonevitsky, Anton A. Sheludchenkov, Nikolai V. Gnuchev, E. A. Romanova, Georgii P. Georgiev, Olga K. Ivanova, Natalia V. Soshnikova, Lidia P. Sashchenko, Denis V. Yashin, Alexander G. Gabibov

Publikováno v: The Journal of biological chemistry. 290(35)

Tag7 (also known as peptidoglycan recognition protein PGRP-S, PGLYRP1), an innate immunity protein, interacts with Hsp70 to form a stable Tag7-Hsp70 complex with cytotoxic activity against some tumor cell lines. In this study, we have analyzed the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0bccc152bf0d37636cb20be23153ef7
https://pubmed.ncbi.nlm.nih.gov/26183779

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Peripheral Sensory Neurons Survive in the Absence of α- and γ-Synucleins

Autor: Vladimir L. Buchman, Natalia Ninkina, Nikolai V. Gnuchev, Katerina K. Papachroni, Julia Wanless, Anastasios Kalofoutis

Publikováno v: Journal of Molecular Neuroscience. 25:157-164

Physiological functions of α-synuclein, a protein implicated in certain types of neurodegeneration, and two other members of the same family, β-synuclein and γ-synuclein, are not clearly understood. It has been suggested that synucleins are involv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a865abf7e6113fe1c2e5cf2ec6d0880
https://doi.org/10.1385/jmn:25:2:157

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[Untitled]

Autor: Dominique Pillet, A. V. Demin, O. V. Grigorieva, Elena Sergeevna Alexandrova, Andrey V. Reshetnyak, Ivan I. Vorobiev, Alexander G. Gabibov, Marjorie Paon, Alain Friboulet, Natalia A. Ponomarenko, K. A. Malishkin, Georgy B. Telegin, Nikolai V. Gnuchev, Daniel Thomas, Dmitry Genkin

Publikováno v: Biochemistry (Moscow). 67:1168-1179

Most of the data accumulated throughout the years on investigation of catalytic antibodies indicate that their pro� duction increases on the background of autoimmune abnormalities. The different approaches to induction of catalytic response toward

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6225e94f560446d8dac5ea341a7e3008
https://doi.org/10.1023/a:1020971509138

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Anti-DNA autoantibodies reveal toxicity to tumor cell lines

Autor: N. A. Zelenova, Nikolai V. Gnuchev, T. V. Bobik, S. V. Khaidukov, A. V. Kozyr, S. V. Suchkov, Alexander G. Gabibov, Lidia P. Sashchenko, A. N. Ignatova, Alexander V. Kolesnikov, Zemfira S. Alekberova

Publikováno v: Immunology Letters. 80:41-47

Cytotoxicity of anti-DNA autoantibodies from sera of SLE and CLL patients was assayed on permanent cell lines L929, HL-60, Raji, and K562. L929 cells appeared to be the most sensitive to antibody treatment. DNA-hydrolyzing properties of the same auto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e449bcf4936f5b60c583a794c94b423e
https://doi.org/10.1016/s0165-2478(01)00308-x

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[Untitled]

Autor: Nikolai V. Gnuchev, A. V. Kibardin, Sergey L. Kiselev, E. S. Zakharova, Kadulin Sg, Zavadskaia Es

Publikováno v: Russian Journal of Genetics. 37:1009-1013

Using the bovine αS1-casein gene, a genetic construct with an endostatin-coding fragment of the mouse collagen XVIII cDNA was designed to express endostatin in milk of transgenic animals. Several transgenic mice were obtained. The mice secreted endo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8d820aaf5420500cb77527a4e1d0b43
https://doi.org/10.1023/a:1011953312893

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