Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nikolai Sepetov"'
Autor:
Cecilia Bonolo de Campos, Yuan Xiao Zhu, Nikolai Sepetov, Sergei Romanov, Laura Ann Bruins, Chang-Xin Shi, Caleb K. Stein, Joachim L. Petit, Alysia N. Polito, Meaghen E. Sharik, Erin W. Meermeier, Gregory J. Ahmann, Ilsel D. Lopez Armenta, Jonas Kruse, P. Leif Bergsagel, Marta Chesi, Nathalie Meurice, Esteban Braggio, A. Keith Stewart
Publikováno v:
Haematologica, Vol 105, Iss 6 (2020)
The cellular cytotoxicity of APY0201, a PIKfyve inhibitor, against multiple myeloma was initially identified in an unbiased in vitro chemical library screen. The activity of APY0201 was confirmed in all 25 cell lines tested and in 40% of 100 ex vivo
Externí odkaz:
https://doaj.org/article/36f9707664964168a6cc9caa0c85b080
Autor:
David H. Drewry, Eidarus Salah, Joel Morris, John P. Overington, Jowita Mikolajczyk, Francis Atkinson, Alexander Tropsha, Karen Lackey, Jonathan M. Elkins, Kamal R. Abdul Azeez, Mark Kunkel, Nikolai Sepetov, Daniel J. Price, Xi Ping Huang, Eric C. Polley, Timothy M. Willson, Beverly A. Teicher, Vita Fedele, Susanne Müller, Ayman Al Haj Zen, William J. Zuercher, Eugene N. Muratov, Sergei Romanov, Paul Bamborough, Bryan L. Roth, Stefan Knapp, Denis Fourches, M. Szklarz
Despite the success of protein kinase inhibitors as approved therapeutics, drug discovery has focused on a small subset of kinase targets. Here we provide a thorough characterization of the Published Kinase Inhibitor Set (PKIS), a set of 367 small-mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef3b54fff9b892e25076832396fb828f
Publikováno v:
Tetrahedron Letters. 36:6623-6626
Synthesis of a differentially protected molecular scaffold for nonpeptide combinatorial libraries is described. Solid phase synthesis of model compounds and nonpeptide combinatorial library as well as the structure elucidation in the absence of codin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2406e5dccaf1848cc4282d4176944ba7
https://doi.org/10.1016/00404-0399(50)1370-w
https://doi.org/10.1016/00404-0399(50)1370-w
Autor:
Bruce Seligmann, Farid Abdul-Latif, Fahad Al-Obeidi, Zuzana Flegelova, Olga Issakova, Petr Kocis, Viktor Krchnak, Kit Lam, Michal Lebl, James Ostrem, Pavel Safar, Nikolai Sepetov, Alena Stierandova, Peter Strop and Peter Wildgoose
Publikováno v:
European Journal of Medicinal Chemistry. 30:319s-335s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef54186ca2eeee48827e02751b124dc5
https://doi.org/10.1016/s0223-5234(23)00133-2
https://doi.org/10.1016/s0223-5234(23)00133-2
Autor:
Viktor Krchnak, Nikolai Sepetov, Peter Strop, Michal Lebl, Bruce Seligmann, Stephen Felder, Kit S. Lam
Publikováno v:
ChemInform. 26
Combinatorial libraries employing the one-bead–one-compound technique are reviewed. Two distinguishing features characterize this technique. First, each compound is identified with a unique solid support, enabling facile segregation of active compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a996eb9f798b22def56547bf07ef765
https://doi.org/10.1002/chin.199543291
https://doi.org/10.1002/chin.199543291
Publikováno v:
ChemInform. 26
Synthesis of a differentially protected molecular scaffold for nonpeptide combinatorial libraries is described. Solid phase synthesis of model compounds and nonpeptide combinatorial library as well as the structure elucidation in the absence of codin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef6f3aeae5305cc16349c7d5a00be3ef
https://doi.org/10.1002/chin.199549097
https://doi.org/10.1002/chin.199549097
Autor:
Zhanna D. Bespalova, Nikolai Sepetov, Mikhail V. Ovchinikov, Vladislav Isakovich Deigin, Elena Petrovna Yarova, A S Molokoedov, Evgenii E. Efremov, Tatyana P. Saks, Andrei Marxovich Korotkov, Pekelis Boris L
Publikováno v:
Collection of Czechoslovak Chemical Communications. 55:2537-2554
Scheme is described for the synthesis of 19- and 21-member peptides which constitute a part of the domain (sequence 584-609) from the conservative region of the transmembrane protein gp 41 HIV-1. The synthesis was carried out using standard methods o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9964c74ea8a7178a34a25ca9e6d8769a
https://doi.org/10.1135/cccc19902537
https://doi.org/10.1135/cccc19902537
Autor:
Nikolai Sepetov, Bruce Seligmann, Viktor Krchnak, Stephen Felder, Michal Lebl, Peter Strop, Kit S. Lam
Publikováno v:
Biopolymers. 37(3)
Combinatorial libraries employing the one-bead–one-compound technique are reviewed. Two distinguishing features characterize this technique. First, each compound is identified with a unique solid support, enabling facile segregation of active compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcae5cfccf82809d1cbfab430754653b
https://pubmed.ncbi.nlm.nih.gov/7718741
https://pubmed.ncbi.nlm.nih.gov/7718741
Publikováno v:
Peptides ISBN: 9789401090711
Peptides
Peptides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c497c545a40c21331b58b3091988b134
https://doi.org/10.1007/978-94-010-9069-8_73
https://doi.org/10.1007/978-94-010-9069-8_73
Autor:
Olga L. Isakova, Mikhail I. Titov, Mikhail V. Ovchinnikov, Nikolai Sepetov, Zhanna D. Bespalova, Aleksandr S. Molokoedov, Inna V. Revenko
Publikováno v:
Collection of Czechoslovak Chemical Communications. 54:784-795
Peptides, corresponding to the N-terminal sequence in atriopeptins, were synthesized by classical methods of peptide chemistry in solution. The obtained peptides were characterized by various physicochemical methods. The scheme and methods of the syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a263e2dc6c7c45f0b4cb5c92c084dff5
https://doi.org/10.1135/cccc19890784
https://doi.org/10.1135/cccc19890784