Výsledky vyhledávání - "Nikolai Otmakhov"

Akademický článek

Fast Decay of CaMKII FRET Sensor Signal in Spines after LTP Induction Is Not Due to Its Dephosphorylation.

Autor: Nikolai Otmakhov, Shaurav Regmi, John E Lisman

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0130457 (2015)

Because CaMKII is the critical Ca(2+) sensor that triggers long-term potentiation (LTP), understanding its activation and deactivation is important. A major advance has been the development of a FRET indicator of the conformational state of CaMKII ca

Externí odkaz: https://doaj.org/article/e5e468eeee1645e5aa52d7410bc90d3c

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Akademický článek

Excitotoxic insult results in a long-lasting activation of CaMKIIα and mitochondrial damage in living hippocampal neurons.

Autor: Nikolai Otmakhov, Elena V Gorbacheva, Shaurav Regmi, Ryohei Yasuda, Andy Hudmon, John Lisman

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0120881 (2015)

Over-activation of excitatory NMDA receptors and the resulting Ca2+ overload is the main cause of neuronal toxicity during stroke. CaMKII becomes misregulated during such events. Biochemical studies show either a dramatic loss of CaMKII activity or i

Externí odkaz: https://doaj.org/article/1a95d161e13f44d2bbbb7555a0014ba9

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Memories of John Lisman

Autor: Leslie C. Griffith, Nonna A. Otmakhova, Nikolai Otmakhov

Publikováno v: Frontiers in Neural Circuits, Vol 12 (2018)
Frontiers in Neural Circuits

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bfb4a8894eb0e72c7e3b267cf3b1b28
https://doi.org/10.3389/fncir.2018.00024

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Measuring CaMKII concentration in dendritic spines

Autor: Nikolai Otmakhov, John E. Lisman

Publikováno v: Journal of Neuroscience Methods. 203:106-114

Here, we present a method for measuring the concentration of endogenous protein in cellular compartments. Importantly, the method is applicable to compartments such as dendritic spines with dimensions often close to the resolution limit of optical mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e3630a729e1dcbd168c759b618dd9ca
https://doi.org/10.1016/j.jneumeth.2011.09.022

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CaMKII control of spine size and synaptic strength: Role of phosphorylation states and nonenzymatic action

Autor: John E. Lisman, Farida El Gaamouch, Paul De Koninck, David Lemelin, Hyun Jae Pi, Nikolai Otmakhov

Publikováno v: Proceedings of the National Academy of Sciences. 107:14437-14442

CaMKII is an abundant synaptic protein strongly implicated in plasticity. Overexpression of autonomous (T286D) CaMKII in CA1 hippocampal cells enhances synaptic strength if T305/T306 sites are not phosphorylated, but decreases synaptic strength if th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5912c5654a39ca93265c3b445e18da90
https://doi.org/10.1073/pnas.1009268107

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Excitotoxic insult results in a long-lasting activation of CaMKIIα and mitochondrial damage in living hippocampal neurons

Autor: Shaurav Regmi, Andy Hudmon, John E. Lisman, Ryohei Yasuda, Elena V. Gorbacheva, Nikolai Otmakhov

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0120881 (2015)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80990e995a15c8c8eee85060d8401e82
http://europepmc.org/articles/PMC4368532?pdf=render

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Persistent Accumulation of Calcium/Calmodulin-Dependent Protein Kinase II in Dendritic Spines after Induction of NMDA Receptor-Dependent Chemical Long-Term Potentiation

Autor: Ayse Dosemeci, Brent Asrican, Jung-Hwa Tao-Cheng, Thomas S. Reese, Stephen M. Carpenter, Nikolai Otmakhov, John E. Lisman

Publikováno v: The Journal of Neuroscience. 24:9324-9331

Calcium/calmodulin-dependent protein kinase II (CaMKII) is a leading candidate for a synaptic memory molecule because it is persistently activated after long-term potentiation (LTP) induction and because mutations that block this persistent activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad551480081134e957b88d6e751274fa
https://doi.org/10.1523/jneurosci.2350-04.2004

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Visualizing hippocampal synaptic function by optical detection of Ca2+ entry through the N-methyl-D-aspartate channel

Autor: John E. Lisman, Roberto Malinow, Kenneth I. Blum, Nikolai Otmakhov

Publikováno v: Proceedings of the National Academy of Sciences. 91:8170-8174

Fura-2 and imaging technology were used to detect intracellular Ca2+ changes in CA1 pyramidal cells in hippocampal slices. During focal synaptic stimulation, one or more highly localized regions of Ca2+ elevation (hot spots) were detected in the dend

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f15df4d27613fb16ad3ffe2b59c1c6bf
https://doi.org/10.1073/pnas.91.17.8170

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Role of the CaMKII/NMDA receptor complex in the maintenance of synaptic strength

Autor: Magdalena Sanhueza, P. Zhang, Ivar S. Stein, K. U. Bayer, G. Fernandez-Villalobos, John E. Lisman, Gyulnara G. Kasumova, Nikolai Otmakhov, Johannes W. Hell

Publikováno v: JOURNAL OF NEUROSCIENCE
Artículos CONICYT
CONICYT Chile
instacron:CONICYT

During long-term potentiation (LTP), synapses undergo stable changes in synaptic strength. The molecular memory processes that maintain strength have not been identified. One hypothesis is that the complex formed by the Ca(2+)/calmodulin-dependent pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132ec68b9375f5b21c32109cc4e68348
https://pubmed.ncbi.nlm.nih.gov/21697368

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