Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Nikolai L. Chepelev"'
Autor:
Nikolai L. Chepelev, Hongqiao Zhang, Honglei Liu, Skye McBride, Andrew J. Seal, Todd E. Morgan, Caleb E. Finch, William G. Willmore, Kelvin J.A. Davies, Henry Jay Forman
Publikováno v:
Redox Biology, Vol 1, Iss 1, Pp 183-189 (2013)
Although the Nrf2 (nuclear factor-erythroid 2 p45 subunit-related factor 2) regulated expression of multiple antioxidant and cytoprotective genes through the electrophile responsive element (EpRE) is well established, interaction of Nrf2/EpRE with Nr
Externí odkaz:
https://doaj.org/article/49883a7b259b43929b1798e014854a47
Autor:
Ella Atlas, Nikolai L. Chepelev, Leslie Recio, Rémi Gagné, Cheryl A. Hobbs, Andrew Williams, Timothy Maynor, Kim G. Shepard, Carole L. Yauk, Vian Peshdary, Byron Kuo
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 72
Bisphenol A (BPA) is a chemical used in the manufacturing of plastics to which human exposure is ubiquitous. Numerous studies have linked BPA exposure to many adverse health outcomes prompting the replacement of BPA with various analogues including b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d82c4402e47fe6b57999cd14268bdc6
https://pubmed.ncbi.nlm.nih.gov/33476716
https://pubmed.ncbi.nlm.nih.gov/33476716
Autor:
Andrea Nævisdal, David H. Phillips, Lisa Hölzl-Armstrong, Volker M. Arlt, Paul D. White, Julie A. Cox, Nikolai L. Chepelev, Alexandra S. Long
Publikováno v:
Mutagenesis
Chemicals in commerce or under development must be assessed for genotoxicity; assessment is generally conducted using validated assays (e.g. Tk mouse lymphoma assay) as part of a regulatory process. Currently, the MutaMouse FE1 cell mutagenicity assa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9401b774607162bf4df80d6f5da65d
https://pubmed.ncbi.nlm.nih.gov/33399867
https://pubmed.ncbi.nlm.nih.gov/33399867
Autor:
Cheryl A. Hobbs, Timothy Maynor, Nikolai L. Chepelev, Byron Kuo, Leslie Recio, Carole L. Yauk, Rémi Gagné
Publikováno v:
Regulatory Toxicology and Pharmacology. 95:75-90
Acrylamide (AA) exposure causes increased incidence of forestomach, lung, and Harderian gland tumors in male mice. One hypothesized mode of action (MOA) for AA-carcinogenicity includes genotoxicity/mutagenicity as a key event, possibly resulting from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203933d2d87b3ddfa6c624be0cd08e1e
https://doi.org/10.1016/j.yrtph.2018.02.005
https://doi.org/10.1016/j.yrtph.2018.02.005
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29167 (2011)
BackgroundNrf1 (nuclear factor-erythroid 2 p45 subunit-related factor 1) is a transcription factor mediating cellular responses to xenobiotic and pro-oxidant stress. Nrf1 regulates the transcription of many stress-related genes through the electrophi
Externí odkaz:
https://doaj.org/article/e6db0690b6f849baa8c9bca45a792be3
Autor:
Nikolai L. Chepelev, Dillon Dong, Melanie C Coughlan, Xu-Liang Cao, Xiaolei Jin, Kylie A. Scoggan, Laziyan Mahemuti, William G. Willmore, Cunye Qiao, Robert G. Woodworth, Jin Yan, Qixuan Chen, Maria Florian
Publikováno v:
Archives of Toxicology. 92:1453-1469
Experimental and/or epidemiological studies suggest that prenatal exposure to bisphenol A (BPA) may delay fetal lung development and maturation and increase the susceptibility to childhood respiratory disease. However, the underlying mechanisms remai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be709103f8f6d8a772d11aaf0b39621
https://doi.org/10.1007/s00204-017-2150-3
https://doi.org/10.1007/s00204-017-2150-3
Autor:
Nikolai L. Chepelev, Andy Nong, Tara S. Barton-Maclaren, Reza Farmahin, Byron Kuo, Carole L. Yauk, Russell S. Thomas, Michael G. Wade, Ivan Curran, Andrew Williams
Publikováno v:
Archives of Toxicology
There is increasing interest in the use of quantitative transcriptomic data to determine benchmark dose (BMD) and estimate a point of departure (POD) for human health risk assessment. Although studies have shown that transcriptional PODs correlate wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf783ace4fbb095be60f7202e529388b
http://europepmc.org/articles/PMC5399047
http://europepmc.org/articles/PMC5399047
Changing gears in Nrf1 research, from mechanisms of regulation to its role in disease and prevention
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1849:1260-1276
The "cap'n'collar" bZIP transcription factor Nrf1 heterodimerizes with small Maf proteins to bind to the Antioxidant Response Element/Electrophile Response Element to transactivate antioxidant enzyme, phase 2 detoxification enzyme and proteasome subu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7df913e8b86601f8b0322a79f2547b43
https://doi.org/10.1016/j.bbagrm.2015.08.001
https://doi.org/10.1016/j.bbagrm.2015.08.001
Publikováno v:
Mutation Research/Reviews in Mutation Research. 764:64-89
Benzo[a]pyrene (BaP) is a well-studied environmental compound that requires metabolic activation to have a carcinogenic effect. The neurotoxicity of BaP has received considerably less attention than its carcinogenicity. Environmental exposure to BaP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6cf09ba474ab4fe05d95a864f5abac
https://doi.org/10.1016/j.mrrev.2015.03.001
https://doi.org/10.1016/j.mrrev.2015.03.001
Autor:
Nikolai L. Chepelev, Ivy D. Moffat, Sarah Labib, Julie Bourdon-Lacombe, Byron Kuo, Julie K. Buick, France Lemieux, Amal I. Malik, Sabina Halappanavar, Andrew Williams, Carole L. Yauk
Publikováno v:
Critical Reviews in Toxicology. 45:44-52
The use of short-term toxicogenomic tests to predict cancer (or other health effects) offers considerable advantages relative to traditional toxicity testing methods. The advantages include increased throughput, increased mechanistic data, and signif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3270207e157de538ef49ef87b828d1ec
https://doi.org/10.3109/10408444.2014.973935
https://doi.org/10.3109/10408444.2014.973935