Zobrazeno 1 - 10
of 195
pro vyhledávání: '"Nikolai Klymiuk"'
Autor:
Kazutoshi Okamoto, Hitomi Matsunari, Kazuaki Nakano, Kazuhiro Umeyama, Koki Hasegawa, Ayuko Uchikura, Shuko Takayanagi, Masahito Watanabe, Jun Ohgane, Michael Stirm, Mayuko Kurome, Nikolai Klymiuk, Masaki Nagaya, Eckhard Wolf, Hiroshi Nagashima
Publikováno v:
Regenerative Therapy, Vol 24, Iss , Pp 451-458 (2023)
Introduction: Duchenne muscular dystrophy (DMD) is a hereditary neuromuscular disorder caused by mutation in the dystrophin gene (DMD) on the X chromosome. Female DMD carriers occasionally exhibit symptoms such as muscle weakness and heart failure. H
Externí odkaz:
https://doaj.org/article/51df675076934a228d6302859f500d01
Autor:
Josep M. Cambra, Maria A. Gil, Cristina Cuello, Alejandro Gonzalez-Plaza, Heriberto Rodriguez-Martinez, Nikolai Klymiuk, Emilio A. Martinez, Inmaculada Parrilla
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
IntroductionPregnancy success relies on the establishment of a delicate immune balance that requires the early activation of a series of local and systemic immune mechanisms. The changes in the immunological profile that are normally occurring in the
Externí odkaz:
https://doaj.org/article/a36bc68472824f59a4b6ba553ad5f48b
Autor:
Martin Bender, Jan-Michael Abicht, Bruno Reichart, Elisabeth Neumann, Julia Radan, Maren Mokelke, Ines Buttgereit, Maria Leuschen, Felicia Wall, Sebastian Michel, Reinhard Ellgass, Stig Steen, Audrius Paskevicius, Andreas Lange, Barbara Kessler, Elisabeth Kemter, Nikolai Klymiuk, Joachim Denner, Antonia W. Godehardt, Ralf R. Tönjes, Jonathan M. Burgmann, Constança Figueiredo, Anastasia Milusev, Valentina Zollet, Neda Salimi-Afjani, Alain Despont, Robert Rieben, Stephan Ledderose, Christoph Walz, Christian Hagl, David Ayares, Eckhard Wolf, Michael Schmoeckel, Paolo Brenner, Uli Binder, Michaela Gebauer, Arne Skerra, Matthias Längin
Publikováno v:
Biomedicines, Vol 12, Iss 8, p 1927 (2024)
The blockade of the CD40/CD40L immune checkpoint is considered essential for cardiac xenotransplantation. However, it is still unclear which single antibody directed against CD40 or CD40L (CD154), or which combination of antibodies, is better at prev
Externí odkaz:
https://doaj.org/article/8c1badf713bc4998ad88ccdb88bead35
Autor:
Ana M. Rodriguez-Piñeiro, Florian Jaudas, Nikolai Klymiuk, Andrea Bähr, Gunnar C. Hansson, Anna Ermund
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Background The respiratory tract is protected from inhaled particles and microbes by mucociliary clearance, mediated by the mucus and the cilia creating a flow to move the mucus cephalad. Submucosal glands secrete linear MUC5B mucin polymers
Externí odkaz:
https://doaj.org/article/bc91ee7d7b494a55acf02008062879a2
Autor:
Constantin von Bibra, Aya Shibamiya, Andrea Bähr, Birgit Geertz, Maria Köhne, Tim Stuedemann, Jutta Starbatty, Verena Horneffer-van der Sluis, Ulrich C. Klostermeier, Nadja Hornaschewitz, Xinghai Li, Eckhard Wolf, Nikolai Klymiuk, Markus Krane, Christian Kupatt, Bernhard Hiebl, Thomas Eschenhagen, Florian Weinberger
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 5 (2023)
Externí odkaz:
https://doaj.org/article/b2f866000a454c14a8dba3101b884926
Autor:
Sophia Grotz, Jessica Schäfer, Kirsten A Wunderlich, Zdenka Ellederova, Hannah Auch, Andrea Bähr, Petra Runa‐Vochozkova, Janet Fadl, Vanessa Arnold, Taras Ardan, Miroslav Veith, Gianluca Santamaria, Georg Dhom, Wolfgang Hitzl, Barbara Kessler, Christian Eckardt, Joshua Klein, Anna Brymova, Joshua Linnert, Mayuko Kurome, Valeri Zakharchenko, Andrea Fischer, Andreas Blutke, Anna Döring, Stepanka Suchankova, Jiri Popelar, Eduardo Rodríguez‐Bocanegra, Julia Dlugaiczyk, Hans Straka, Helen May‐Simera, Weiwei Wang, Karl‐Ludwig Laugwitz, Luk H Vandenberghe, Eckhard Wolf, Kerstin Nagel‐Wolfrum, Tobias Peters, Jan Motlik, M Dominik Fischer, Uwe Wolfrum, Nikolai Klymiuk
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 4, Pp 1-24 (2022)
Abstract Usher syndrome (USH) is the most common form of monogenic deaf‐blindness. Loss of vision is untreatable and there are no suitable animal models for testing therapeutic strategies of the ocular constituent of USH, so far. By introducing a h
Externí odkaz:
https://doaj.org/article/f0ba22f95e7b4b36b03173d767e7f90f
Autor:
Anna Ermund, Lauren N. Meiss, Brendan Dolan, Florian Jaudas, Lars Ewaldsson, Andrea Bähr, Nikolai Klymiuk, Gunnar C. Hansson
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Background The mucociliary clearance system driven by beating cilia protects the airways from inhaled microbes and particles. Large particles are cleared by mucus bundles made in submucosal glands by parallel linear polymers of the MUC5B muc
Externí odkaz:
https://doaj.org/article/ddf81e3cc48d4be383cadbc953dd2e50
Publikováno v:
PeerJ, Vol 10, p e14202 (2022)
Recent studies have revealed the dynamic and complex evolution of CLCA1 gene homologues in and between mammals and birds with a particularly high diversity in mammals. In contrast, CLCA2 has only been found as a single copy gene in mammals, to date.
Externí odkaz:
https://doaj.org/article/f566e777f8e94a7f8b87a7f25af62126
Autor:
Florian Bartenschlager, Nikolai Klymiuk, Christoph Weise, Benno Kuropka, Achim D. Gruber, Lars Mundhenk
Publikováno v:
PLoS ONE, Vol 17, Iss 4 (2022)
Species-specific diversities are particular features of mammalian chloride channel regulator, calcium activated (CLCA) genes. In contrast to four complex gene clusters in mammals, only two CLCA genes appear to exist in chickens. CLCA2 is conserved in
Externí odkaz:
https://doaj.org/article/1ecd782e780c4d8b875a804bab051336
Autor:
Michael Stirm, Lina Marie Fonteyne, Bachuki Shashikadze, Magdalena Lindner, Maila Chirivi, Andreas Lange, Clara Kaufhold, Christian Mayer, Ivica Medugorac, Barbara Kessler, Mayuko Kurome, Valeri Zakhartchenko, Arne Hinrichs, Elisabeth Kemter, Sabine Krause, Rüdiger Wanke, Georg J. Arnold, Gerhard Wess, Hiroshi Nagashima, Martin Hrabĕ de Angelis, Florian Flenkenthaler, Levin Arne Kobelke, Claudia Bearzi, Roberto Rizzi, Andrea Bähr, Sven Reese, Kaspar Matiasek, Maggie C. Walter, Christian Kupatt, Sibylle Ziegler, Peter Bartenstein, Thomas Fröhlich, Nikolai Klymiuk, Andreas Blutke, Eckhard Wolf
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 12 (2021)
Large-animal models for Duchenne muscular dystrophy (DMD) are crucial for the evaluation of diagnostic procedures and treatment strategies. Pigs cloned from male cells lacking DMD exon 52 (DMDΔ52) exhibit molecular, clinical and pathological hallmar
Externí odkaz:
https://doaj.org/article/d8939e99103646a0a9090e1ac2200524