Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Nikolai Kholodilov"'
Autor:
Soyeon Park, Robert E Burke, Tatyana Kareva, Nikolai Kholodilov, Pascaline Aimé, Thomas F Franke, Oren Levy, Lloyd A Greene
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0197899 (2018)
Akt kinases are key signaling components in proliferation-competent and post-mitotic cells. Here, we sought to create a conditionally-inducible form of active Akt for both in vitro and in vivo applications. We fused a ligand-responsive Destabilizing
Externí odkaz:
https://doaj.org/article/be6db423c8924f3cb2b7de2d3e555447
Autor:
Patricia Tagliaferro, Tatyana Kareva, Tinmarla F. Oo, Olga Yarygina, Nikolai Kholodilov, Robert E. Burke
Publikováno v:
Neurobiology of Disease, Vol 82, Iss , Pp 359-371 (2015)
Mutations in the gene for LRRK2 are the most common cause of familial Parkinson's disease (PD) and patients with these mutations manifest clinical features that are indistinguishable from those of the more common sporadic form. Thus, investigations o
Externí odkaz:
https://doaj.org/article/fe137f3579be4d7d9334cbc2107244fb
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
The use of viral vectors to transfect postmitotic neurons has provided an important research tool, and it offers promise for treatment of neurologic disease. The utility of vectors is enhanced by the use of selective promoters that permit control of
Externí odkaz:
https://doaj.org/article/92e30da49dfe4b48bcb14bcf23289bb4
Autor:
Sang Ryong Kim, Vincent Ries, Hsiao-Chun Cheng, Tatyana Kareva, Tinmarla F. Oo, W. Haung Yu, Karen Duff, Nikolai Kholodilov, Robert E. Burke
Publikováno v:
Neurobiology of Disease, Vol 44, Iss 2, Pp 215-222 (2011)
The mechanisms underlying the chronic neurodegeneration that occurs in Parkinson's disease (PD) are unknown. One emerging hypothesis is that neural systems deteriorate and eventually degenerate due to a primary failure of either extrinsic neurotrophi
Externí odkaz:
https://doaj.org/article/8cd59f1f030f417397036445fce9ad39
Autor:
Nikolai Kholodilov, Theresa Connors, Michelle C. Klaw, Marie-Pascale Côté, Di Wu, Veronica J. Tom, Robert E. Burke
Publikováno v:
Molecular Therapy. 25:2715-2726
After spinal cord injury (SCI), severed axons in the adult mammalian CNS are unable to mount a robust regenerative response. In addition, the glial scar at the lesion site further restricts the regenerative potential of axons. We hypothesized that a
Autor:
Un Ju Jung, Kwang Seok Ahn, Yong-Seok Oh, Byung Kwan Jin, Won-Ho Shin, Jae-Young Um, Kea Joo Lee, Nikolai Kholodilov, Seok-Geun Lee, Jae Man Lee, Hyung-Jun Kim, Eunju Leem, Sehwan Kim, Minji Choi, Catriona McLean, Jae Yeong Jeong, Youngshik Choe, Dong Woon Kim, Paul B. Fisher, Sang Ryong Kim
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 9, Iss 5, Pp 1-15 (2018)
Cell Death and Disease, Vol 9, Iss 5, Pp 1-15 (2018)
The role of astrocyte elevated gene-1 (AEG-1) in nigral dopaminergic (DA) neurons has not been studied. Here we report that the expression of AEG-1 was significantly lower in DA neurons in the postmortem substantia nigra of patients with Parkinson’
Autor:
Lloyd A. Greene, Robert E. Burke, Tatyana Kareva, Pascaline Aimé, Nikolai Kholodilov, Soyeon Park, Oren A. Levy, Thomas F. Franke
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0197899 (2018)
PLoS ONE
PLoS ONE
Akt kinases are key signaling components in proliferation-competent and post-mitotic cells. Here, we sought to create a conditionally-inducible form of active Akt for both in vitro and in vivo applications. We fused a ligand-responsive Destabilizing
Autor:
Yong-Seok Oh, Jungha Park, Gyeong Joon Moon, Seok-Geun Lee, Sehwan Kim, Chang Man Ha, Hyung-Jun Kim, Sang Ryong Kim, Robert E. Burke, Byung Kwan Jin, Nikolai Kholodilov, Jae Yeong Jeong, Won-Ho Shin, Kwang Shik Choi
Publikováno v:
Experimental & Molecular Medicine
We recently reported that adeno-associated virus serotype 1 (AAV1) transduction of murine nigral dopaminergic (DA) neurons with constitutively active ras homolog enriched in brain with a mutation of serine to histidine at position 16 [Rheb(S16H)] ind
Publikováno v:
Neuroscience. 346
Adeno-associated viruses (AAVs) have become powerful tools in neuroscience for both basic research and potential therapeutic use. They have become especially important tools for optogenetic experiments based on their ability to achieve transgene expr
Autor:
Nikolai Kholodilov, Megan Ryan Detloff, Veronica J. Tom, Marie-Pascale Côté, Michelle C. Klaw, Robert E. Burke, Di Wu
Publikováno v:
Frontiers in Molecular Neuroscience
While the peripheral branch of dorsal root ganglion neurons (DRG) can successfully regenerate after injury, lesioned central branch axons fail to regrow across the dorsal root entry zone (DREZ), the interface between the dorsal root and the spinal co