Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Nikolai Chetverikov"'
Autor:
Dominik Nelic, Nikolai Chetverikov, Martina Hochmalová, Christina Diaz, Vladimír Doležal, John Boulos, Jan Jakubík, Kirill Martemyanov, Alena Janoušková-Randáková
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Selective activation of individual subtypes of muscarinic receptors is a promising way to safely alleviate a wide range of pathological conditions in the central nervous system and the periphery as well. The flexible G-protein interface of m
Externí odkaz:
https://doaj.org/article/03ce4b98fb3949499a075156508c3010
Autor:
Ewa Szczurowska, Eszter Szánti-Pintér, Nikolai Chetverikov, Alena Randáková, Eva Kudová, Jan Jakubík
Publikováno v:
International Journal of Molecular Sciences. 24:507
Muscarinic acetylcholine receptors expressed in the central nervous system mediate various functions, including cognition, memory, or reward. Therefore, muscarinic receptors represent potential pharmacological targets for various diseases and conditi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::419ef4f5cd50c2415385a2e13fbe07c8
https://doi.org/10.3390/ijms24010507
https://doi.org/10.3390/ijms24010507
Autor:
Dominik Nelic, Eszter Szánti-Pintér, Jan Jakubík, Eva Kudova, Vladimír Doležal, Alena Randáková, Eva Dolejší, Nikolai Chetverikov
The membrane cholesterol was found to bind and modulate the function of several G-protein coupled receptors including muscarinic acetylcholine receptors. We investigated the binding of 20 steroidal compounds including neurosteroids and steroid hormon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05a4a8efeeac59d5e8c829913689ae2a
https://doi.org/10.21203/rs.3.rs-140412/v1
https://doi.org/10.21203/rs.3.rs-140412/v1
Autor:
Dominik Nelic, Jan Jakubík, Eszter Szánti-Pintér, Eva Kudova, Eva Dolejší, Nikolai Chetverikov, Alena Randáková, Vladimír Doležal
Publikováno v:
Neuropharmacology. 199
The membrane cholesterol was found to bind and modulate the function of several G-protein coupled receptors including muscarinic acetylcholine receptors. We investigated the binding of 20 steroidal compounds including neurosteroids and steroid hormon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed74c6a960daeed6b53cc6e7e4a5379
https://pubmed.ncbi.nlm.nih.gov/34555368
https://pubmed.ncbi.nlm.nih.gov/34555368
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
Proper determination of agonist efficacy is indispensable in the evaluation of agonist selectivity and bias to activation of specific signalling pathways. The operational model (OM) of pharmacological agonism is a useful means for achieving this goal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1747cd1aa694eefc177db3cb6027061c
http://europepmc.org/articles/PMC7468285
http://europepmc.org/articles/PMC7468285
Autor:
Jan Jakubík, Dominik Nelic, Vladimír Doležal, Nikolai Chetverikov, Eva Dolejší, Eszter Szánti-Pintér, Alena Randáková, Eva Kudova, Esam E. El-Fakahany
Publikováno v:
Biochemical Pharmacology. 192:114699
Endogenous neurosteroids and their synthetic analogues-neuroactive steroids-have been found to bind to muscarinic acetylcholine receptors and allosterically modulate acetylcholine binding and function. Using radioligand binding experiments we investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0580ce39708b1733accee76aec417c
https://doi.org/10.1016/j.bcp.2021.114699
https://doi.org/10.1016/j.bcp.2021.114699
Publikováno v:
Journal of the History of Economic Thought (Cambridge University Press); Sep2022, Vol. 44 Issue 3, p456-476, 21p
Autor:
Nelic, Dominik1 (AUTHOR), Chetverikov, Nikolai1 (AUTHOR), Hochmalová, Martina1 (AUTHOR), Diaz, Christina2 (AUTHOR), Doležal, Vladimír1 (AUTHOR), Boulos, John2 (AUTHOR), Jakubík, Jan1 (AUTHOR), Martemyanov, Kirill3 (AUTHOR) kmartemyanov@ufl.edu, Janoušková-Randáková, Alena1,3 (AUTHOR) alena.janouskova@fgu.cas.cz
Publikováno v:
Scientific Reports. 4/26/2024, Vol. 14 Issue 1, p1-18. 18p.
Autor:
Szczurowska, Ewa1 (AUTHOR), Szánti-Pintér, Eszter1 (AUTHOR), Chetverikov, Nikolai2 (AUTHOR), Randáková, Alena2 (AUTHOR), Kudová, Eva1 (AUTHOR) eva.kudova@uochb.cas.cz, Jakubík, Jan2 (AUTHOR) eva.kudova@uochb.cas.cz
Publikováno v:
International Journal of Molecular Sciences. Jan2023, Vol. 24 Issue 1, p507. 27p.
Publikováno v:
Journal of Neurochemistry; Aug2023 Supplement 1, Vol. 166, p89-146, 58p