Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Nikolai B. Ulyanov"'
Autor:
Wasif Al-Shareef, Yogev Brown, Christopher Bryan, Elena Shuvaeva, Shhadeh Bsoul, Raanan Greenman, Majdi M. Kabaha, Nikolai B. Ulyanov, Emmanuel Skordalakes, Yehuda Tzfati
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10757 (2022)
The ribonucleoprotein telomerase contains two essential components: telomerase RNA (TER) and telomerase reverse transcriptase (TERT, Est2 in yeast). A small portion of TER, termed the template, is copied by TERT onto the chromosome ends, thus compens
Externí odkaz:
https://doaj.org/article/00b3502e00e04f59b907a940da7093aa
Autor:
Wasif, Al-Shareef, Yogev, Brown, Christopher, Bryan, Elena, Shuvaeva, Shhadeh, Bsoul, Raanan, Greenman, Majdi M, Kabaha, Nikolai B, Ulyanov, Emmanuel, Skordalakes, Yehuda, Tzfati
Publikováno v:
International journal of molecular sciences. 23(18)
The ribonucleoprotein telomerase contains two essential components: telomerase RNA (TER) and telomerase reverse transcriptase (TERT, Est2 in yeast). A small portion of TER, termed the template, is copied by TERT onto the chromosome ends, thus compens
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
11 pags, 7 figs, 3 tabs. -- Supporting information is available at the Publisher's web
The human ribonucleoprotein telomerase is a validated anticancer drug target, and hTR-P2b is a part of the human telomerase RNA (hTR) essential for its activi
The human ribonucleoprotein telomerase is a validated anticancer drug target, and hTR-P2b is a part of the human telomerase RNA (hTR) essential for its activi
Publikováno v:
Nucleic Acids Research
Nucleic acids research, vol 35, iss 18
Nucleic acids research, vol 35, iss 18
Telomerase maintains the integrity of telomeres, the ends of linear chromosomes, by adding G-rich repeats to their 3'-ends. Telomerase RNA is an integral component of telomerase. It contains a template for the synthesis of the telomeric repeats by th
Autor:
Janet Chung, Tristram G. Parslow, Thomas L. James, Nikolai B. Ulyanov, Anwer Mujeeb, Ivan Smirnov, Stefanos Georgantis
Publikováno v:
Nucleic Acids Research
Nucleic acids research, vol 35, iss 6
Nucleic acids research, vol 35, iss 6
Specific binding of HIV-1 viral protein NCp7 to a unique 35-base RNA stem-loop SL1 is critical for formation and packaging of the genomic RNA dimer found within HIV-1 virions. NCp7 binding stimulates refolding of SL1 from a metastable kissing dimer (
Autor:
Yogev Brown, Kinneret Shefer, Yehuda Tzfati, Valentin Gorkovoy, Tamar Nussbaum, Nikolai B. Ulyanov
Publikováno v:
Molecular and Cellular Biology. 27:2130-2143
Telomerase copies a short template within its integral telomerase RNA onto eukaryotic chromosome ends, compensating for incomplete replication and degradation. Telomerase action extends the proliferative potential of cells, and thus it is implicated
Autor:
Tristram G. Parslow, Anwer Mujeeb, Marco Tonelli, Nikolai B. Ulyanov, Thomas L. James, Zhihua Du
Publikováno v:
Journal of Biological Chemistry. 281:16168-16177
The packaging signal of HIV-1 RNA contains a stem-loop structure, SL1, which serves as the dimerization initiation site for two identical copies of the genome and is important for packaging of the RNA genome into the budding virion and for overall in
Autor:
Luis R. Comolli, William H. Gmeiner, Ana M. Soto, Luis A. Marky, Thomas L. James, Nikolai B. Ulyanov
Publikováno v:
Nucleic Acids Research. 30:4371-4379
The NMR structure of the 3′ stem–loop (3′SL) from human U4 snRNA was determined to gain insight into the structural basis for conservation of this stem–loop sequence from vertebrates. 3′SL sequences from human, rat, mouse and chicken U4 snR
Publikováno v:
Journal of Biomolecular NMR. 22:265-280
We have determined, by proton NMR and complete relaxation matrix methods, the high-resolution structure of a DNA oligonucleotide in solution with nine contiguous AT base pairs. The stretch of AT pairs, TAATTATAA x TTATAATTA, is imbedded in a 27-nucle
Publikováno v:
Biochemistry. 40:7239-7246
In DNA duplexes, pyrimidine-purine steps are believed to be flexible or conformationally unstable. Indeed, several DNA crystal structures exhibit a multitude of conformations for CpA*TpG steps. The question arises of whether this structural flexibili