Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Nikolai, Schleussner"'
Autor:
Naita Maren Wirsik, Mingyi Chen, Liping He, Uraz Yasar, Justus Gaukel, Alexander Quaas, Henrik Nienhüser, Ella Leugner, Shuai Yuan, Nikolai Schleussner, Jin‐On Jung, Jadie Sue Plücker, Martin Schneider, Thomas Schmidt
Publikováno v:
Cancer Medicine, Vol 13, Iss 7, Pp n/a-n/a (2024)
Abstract Background Despite multiple therapeutic modalities, the overall survival of patients with gastric adenocarcinoma remains poor, especially for advanced tumor stages. Although the tyrosine kinase MerTK has shown therapeutic relevance in severa
Externí odkaz:
https://doaj.org/article/5215e54f8b1c4affb0d583011102a3c1
Autor:
Nikolai Schleussner, Pierre Cauchy, Vedran Franke, Maciej Giefing, Oriol Fornes, Naveen Vankadari, Salam A. Assi, Mariantonia Costanza, Marc A. Weniger, Altuna Akalin, Ioannis Anagnostopoulos, Thomas Bukur, Marco G. Casarotto, Frederik Damm, Oliver Daumke, Benjamin Edginton-White, J. Christof M. Gebhardt, Michael Grau, Stephan Grunwald, Martin-Leo Hansmann, Sylvia Hartmann, Lionel Huber, Eva Kärgel, Simone Lusatis, Daniel Noerenberg, Nadine Obier, Ulrich Pannicke, Anja Fischer, Anja Reisser, Andreas Rosenwald, Klaus Schwarz, Srinivasan Sundararaj, Andre Weilemann, Wiebke Winkler, Wendan Xu, Georg Lenz, Klaus Rajewsky, Wyeth W. Wasserman, Peter N. Cockerill, Claus Scheidereit, Reiner Siebert, Ralf Küppers, Rudolf Grosschedl, Martin Janz, Constanze Bonifer, Stephan Mathas
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Disease-causing mutations in genes encoding transcription factors (TFs) can affect TF interactions with their cognate DNA-binding motifs. Whether and how TF mutations impact upon the binding to TF composite elements (CE) and the interaction
Externí odkaz:
https://doaj.org/article/89617bbfc2d9437a8c22b2474e5ec08c
Autor:
Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W. Zimmerman, Elisabeth Gurnhofer, Ivonne A. Montes-Mojarro, Brian J. Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Zammarchi, Daniel-Adriano Silva, K. Christopher Garcia, David Baker, Martin Janz, Nikolai Schleussner, Falko Fend, Šárka Pospíšilová, Andrea Janiková, Jacqueline Wallwitz, Dagmar Stoiber, Ingrid Simonitsch-Klupp, Lorenzo Cerroni, Stefano Pileri, Laurence de Leval, David Sibon, Virginie Fataccioli, Philippe Gaulard, Chalid Assaf, Fabian Knörr, Christine Damm-Welk, Wilhelm Woessmann, Suzanne D. Turner, A. Thomas Look, Stephan Mathas, Lukas Kenner, Olaf Merkel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Anaplastic large cell lymphoma (ALCL) is an aggressive T-cell lymphoma often with poor prognosis. To identify genes defining ALCL cell state and dependencies, the authors here characterize ALCL-specific super-enhancers and describe the BATF3/IL-2R−
Externí odkaz:
https://doaj.org/article/6005c21ca6e84b989b1eb0469795a79b
Autor:
Cristina Lopez, Nikolai Schleussner, Stephan H. Bernhart, Kortine Kleinheinz, Stephanie Sungalee, Henrike L. Sczakiel, Helene Kretzmer, Umut H. Toprak, Selina Glaser, Rabea Wagener, Ole Ammerpohl, Susanne Bens, Maciej Giefing, Juan C. Gonzalez Sanchez, Gordana Apic, Daniel Hubschmann, Martin Janz, Markus Kreuz, Anja Mottok, Judith M. Muller, Julian Seufert, Steve Hoffmann, Jan O. Korbel, Robert B. Russell, Roland Schule, Lorenz Trumper, Wolfram Klapper, Bernhard Radlwimmer, Peter Lichter, Ralf Kuppers, Matthias Schlesner, Stephan Mathas, Reiner Siebert
Publikováno v:
Haematologica, Vol 108, Iss 2 (2022)
Histone methylation-modifiers, such as EZH2 and KMT2D, are recurrently altered in B-cell lymphomas. To comprehensively describe the landscape of alterations affecting genes encoding histone methylation-modifiers in lymphomagenesis we investigated who
Externí odkaz:
https://doaj.org/article/3d3b5d4cbb534e4eb3816d334f4e9a3c
Autor:
Martin Schneider, Nikolai Schleussner
Publikováno v:
Wiener klinisches Magazin. 25:100-109
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4ece5d2617ed195b6779161cccfd63
https://doi.org/10.1007/s00740-022-00442-3
https://doi.org/10.1007/s00740-022-00442-3
Autor:
Nikolai Schleussner, Pierre Cauchy, Vedran Franke, Maciej Giefing, Oriol Fornes, Naveen Vankadari, Salam Assi, Mariantonia Costanza, Marc A. Weniger, Altuna Akalin, Ioannis Anagnostopoulos, Thomas Bukur, Marco G. Casarotto, Frederik Damm, Oliver Daumke, Benjamin Edginton-White, J. Christof M. Gebhardt, Michael Grau, Stephan Grunwald, Martin-Leo Hansmann, Sylvia Hartmann, Lionel Huber, Eva Kärgel, Simone Lusatis, Daniel Noerenberg, Nadine Obier, Ulrich Pannicke, Anja Pfaus, Anja Reisser, Andreas Rosenwald, Klaus Schwarz, Srinivasan Sundararaj, Andre Weilemann, Wiebke Winkler, Wendan Xu, Georg Lenz, Klaus Rajewsky, Wyeth W. Wasserman, Peter N. Cockerill, Claus Scheidereit, Reiner Siebert, Ralf Küppers, Rudolf Grosschedl, Martin Janz, Constanze Bonifer, Stephan Mathas
SUMMARY PARAGRAPHDisease-causing mutations in genes encoding transcription factors (TFs) are a recurrent finding in hematopoietic malignancies and might involve key regulators of lineage adherence and cellular differentiation1–3. Such mutations can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd3316c398bb4961ae21419171bf62ab
https://doi.org/10.1101/2022.12.29.522203
https://doi.org/10.1101/2022.12.29.522203
Autor:
Nuria Vaquero-Siguero, Nikolai Schleussner, Julia Volk, Manuel Mastel, Jasmin Meier, Rene Jackstadt
Publikováno v:
Cancers; Volume 14; Issue 17; Pages: 4260
Colorectal cancer (CRC) is among the deadliest cancers worldwide, with metastasis being the main cause of patient mortality. During CRC progression the complex tumor ecosystem changes in its composition at virtually every stage. However, clonal dynam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b55bd2f240a95a1a09225c8a2a357418
https://pubmed.ncbi.nlm.nih.gov/36077793
https://pubmed.ncbi.nlm.nih.gov/36077793
Autor:
Nina, Weisshaar, Jingxia, Wu, Yanan, Ming, Alaa, Madi, Agnes, Hotz-Wagenblatt, Sicong, Ma, Alessa, Mieg, Marvin, Hering, Ferdinand, Zettl, Kerstin, Mohr, Tilo, Schlimbach, Nora, Ten Bosch, Franziska, Hertel, Lisann, Müller, Hannah, Byren, Mona, Wang, Helena, Borgers, Mareike, Munz, Lukas, Schmitt, Franciscus, van der Hoeven, Ulrich, Kloz, Rafael, Carretero, Nikolai, Schleußner, Rene-Filip, Jackstadt, Ilse, Hofmann, Guoliang, Cui
Publikováno v:
Science immunology. 7(71)
T cells become functionally exhausted in tumors, limiting T cell-based immunotherapies. Although several transcription factors regulating the exhausted T (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9620d0bb0beb3c5a8c55553a3cfe2fb7
https://pubmed.ncbi.nlm.nih.gov/35622904
https://pubmed.ncbi.nlm.nih.gov/35622904
Autor:
Stephan Kreher, Lukas Kenner, Kathrin D Wurster, Olaf Merkel, Nikolai Schleussner, Arjan Diepstra, Reiner Siebert, Bernd Gillissen, Ioannis Anagnostopoulos, Mariantonia Costanza, Selina Glaser, Björn Lamprecht, Arturo Molina, Karl Köchert, Harald Stein, Korinna Jöhrens, Michael Hummel, Martin Janz, Stephan Mathas
Publikováno v:
Cancers
Volume 13
Issue 19
Cancers, 13(19):5012. MDPI AG
Cancers, Vol 13, Iss 5012, p 5012 (2021)
Volume 13
Issue 19
Cancers, 13(19):5012. MDPI AG
Cancers, Vol 13, Iss 5012, p 5012 (2021)
In 50–60% of cases, systemic anaplastic large cell lymphoma (ALCL) is characterized by the t(2
5)(p23
q35) or one of its variants, considered to be causative for anaplastic lymphoma kinase (ALK)-positive (ALK+) ALCL. Key pathogenic events
5)(p23
q35) or one of its variants, considered to be causative for anaplastic lymphoma kinase (ALK)-positive (ALK+) ALCL. Key pathogenic events
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5346c43823c376467e77edb3e2df8f3a
http://europepmc.org/articles/PMC8507667
http://europepmc.org/articles/PMC8507667
Autor:
Cristina, Lopez, Nikolai, Schleussner, Stephan H, Bernhart, Kortine, Kleinheinz, Stephanie, Sungalee, Henrike L, Sczakiel, Helene, Kretzmer, Umut H, Toprak, Selina, Glaser, Rabea, Wagener, Ole, Ammerpohl, Susanne, Bens, Maciej, Giefing, Juan C Gonzalez, Sanchez, Gordana, Apic, Daniel, Hubschmann, Martin, Janz, Markus, Kreuz, Anja, Mottok, Judith M, Muller, Julian, Seufert, Steve, Hoffmann, Jan O, Korbel, Robert B, Russell, Roland, Schule, Lorenz, Trumper, Wolfram, Klapper, Bernhard, Radlwimmer, Peter, Lichter, Ralf, Kuppers, Matthias, Schlesner, Stephan, Mathas, Reiner, Siebert
Publikováno v:
Haematologica.
Histone methylation-modifiers, like EZH2 and KMT2D, are recurrently altered in B-cell lymphomas. To comprehensively describe the landscape of alterations affecting genes encoding histone methylation-modifiers in lymphomagenesis we investigated whole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9674233f991554afd14bb4f5decea79d
https://pubmed.ncbi.nlm.nih.gov/35522148
https://pubmed.ncbi.nlm.nih.gov/35522148